Article
Multidisciplinary Sciences
Xiaoyu Wei, Sulei Fu, Hanbo Li, Yang Liu, Shuai Wang, Weimin Feng, Yunzhi Yang, Xiawei Liu, Yan-Yun Zeng, Mengnan Cheng, Yiwei Lai, Xiaojie Qiu, Liang Wu, Nannan Zhang, Yujia Jiang, Jiangshan Xu, Xiaoshan Su, Cheng Peng, Lei Han, Wilson Pak-Kin Lou, Chuanyu Liu, Yue Yuan, Kailong Ma, Tao Yang, Xiangyu Pan, Shang Gao, Ao Chen, Miguel A. Esteban, Huanming Yang, Jian Wang, Guangyi Fan, Longqi Liu, Liang Chen, Xun Xu, Ji-Feng Fei, Ying Gu
Summary: This study used Stereo-seq technology to analyze spatial distribution and molecular features of axolotl brain during development and regeneration. The researchers identified an injury-induced ependymoglial cell cluster as a potential progenitor cell population for replenishing lost neurons. They also discovered regressed neurons and provided evidence for the involvement of resident ependymoglial cells in neurogenesis.
Article
Immunology
Jasmina Bier, Sebastian M. Steiger, Holger M. Reichardt, Fred Luehder
Summary: The study investigated the impact of antigen priming on the sensitivity of T cells to glucocorticoid-induced apoptosis, revealing the different responses of antigen-primed effector T cells compared to naïve T cells to synthetic GCs in vitro and in vivo. The findings suggest that antigen priming influences the sensitivity of T cells to therapeutic GCs in the context of inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
J. Y. Fu, C. X. Jiang, M. Y. Wu, R. Y. Mei, A. F. Yang, H. P. Tao, X. J. Chen, J. Zhang, L. Huang, X. F. Zhao
Summary: Theabrownin (TB) has shown potential as an antitumor agent in glioma cells by significantly reducing cell viability and inducing cell cycle arrest through modulation of various proteins. Different mechanisms related to c-myc and P53 were proposed for cell cycle arrest in different glioma cell lines. TB could be a novel candidate drug for the treatment of gliomas based on these findings.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Meng Qu, Guoxin Zhang, Han Qu, Alexander Vu, Raymond Wu, Hidekazu Tsukamoto, Zhenyu Jia, Wendong Huang, Heinz-Josef Lenz, Jeremy N. Rich, Steve A. Kay
Summary: Hepatocellular carcinoma (HCC) is a global health challenge with increasing incidence worldwide. The circadian clock has been shown to play a key role in hepatocarcinogenesis, but the cellular and molecular mechanisms underlying the HCC-clock crosstalk are unknown. In this study, we found that HCC cells rely on the circadian clock transcription factors BMAL1 and CLOCK for cell growth, and down-regulation of these factors induces apoptosis and cell cycle arrest. Mechanistically, inhibiting BMAL1/CLOCK dysregulates cell cycle regulators Wee1 and p21, leading to tumor cell death. Our findings provide insights into the cellular impact of clock proteins in HCC oncogenesis and suggest a potential therapeutic approach based on modulation of the circadian clock.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Ana Garcia-Osta, Jinya Dong, Maria Jesus Moreno-Aliaga, Maria Javier Ramirez
Summary: The cell cycle is regulated by factors such as p27(Kip1), which controls different functions in the nucleus and cytoplasm. In Alzheimer's disease, alterations to cell cycle events and increased neurogenesis have been observed, suggesting a role for p27(Kip1) in the disease process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Romain Le Bail, Antonela Bonafina, Ira Espuny-Camacho, Laurent Nguyen
Summary: This article summarizes the current knowledge on cell diversity in the cortex and other brain regions from in vivo mouse models and in vitro models based on pluripotent stem cells, including cell proliferation, temporal progression, simulation of specific transcriptional and connectivity patterns, and the application of human brain organoid models. The article discusses insights into human cortical evolution from stem cell models and the competence of human brain organoid models to recapitulate the essence of human brain development.
CURRENT OPINION IN NEUROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jin-yi Liu, Wei-qi Fu, Xiang-jin Zheng, Wan Li, Li-wen Ren, Jin-hua Wang, Cui Yang, Guan-hua Du
Summary: Avasimibe demonstrated potent anticancer effects on human glioblastoma cells by inhibiting proliferation, inducing apoptosis, and regulating multiple signaling pathways. The drug showed promising potential as a chemotherapy treatment for glioblastoma.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Cell Biology
Qiong Liu, Lingying Chen, Wenjun Yin, Yuehua Nie, Penghui Zeng, Xin Yang
Summary: The study demonstrated that ginkgetin has an anti-tumor effect on human hepatocellular carcinoma cell lines by inducing apoptosis through affecting the balance between cell proliferation and apoptosis.
Article
Chemistry, Multidisciplinary
Edgar Uhl, Friederike Wolff, Sriyash Mangal, Henry Dube, Esther Zanin
Summary: The research reveals that the versatile proteasome inhibitor MG132, inactivated with a photolabile protection group, can be restored with blue light irradiation, causing cancer cells to arrest during metaphase of the cell cycle or undergo apoptosis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Neurosciences
Maryam Akhavan Tavakoli, Maryam Soleimani, Hassan Marzban, Ronak Shabani, Fatemeh Moradi, Marziyeh Ajdary, Mehdi Mehdizadeh
Summary: The interaction between autophagy and apoptosis plays a crucial role in cell death, particularly in neurodegenerative diseases. This study investigated the effects of fluoxetine (FLX) and cannabidiol (CBD) on demyelination rate in a mouse model of experimental autoimmune encephalomyelitis (EAE). The results showed that FLX and CBD increased autophagic markers and reduced pro-apoptotic markers, leading to a significant decrease in demyelination. Combined treatment with these agents may be a potential strategy for further investigations.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Qiang Wang, Liuming Zhang, Dejun Ji, Jingwen Qu, Jian Wang, Hao Zhang, Yongjun Li
Summary: This study investigated the regulation and function of CMTM3 in hair follicle stem cells. It was found that CMTM3 re-expression suppressed HFSC proliferation by inducing cell cycle arrest and apoptosis, while downregulation of CMTM3 promoted proliferation. Transcriptome analysis identified multiple genes and pathways involved in this process, suggesting a complex crosstalk between pathways and transcription factors mediated by CMTM3.
Article
Oncology
Si-Liang Wei, Jing-Jing Ye, Li Sun, Lei Hu, Yuan-Yuan Wei, Da-Wei Zhang, Meng-Meng Xu, Guang-He Fei
Summary: This study identified a novel mechanism involving circKIF20B/miR-615-3p/MEF2A signaling axis in the progression of gefitinib resistance in NSCLC. Downregulation of circKIF20B promotes resistance to gefitinib, while upregulation restores sensitivity. Exosomal circKIF20B may serve as a potential therapeutic target and liquid biopsy candidate in gefitinib-resistant NSCLC.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Jeyce Kelle Ferreira de Andrade, Alexandre Jose da Silva Goes, Vanessa Xavier Barbosa, Mariza Severina de Lima Silva, Mariana Aragao Matos Donato, Christina Alves Peixoto, Gardenia Carmen Gadelha Militao, Teresinha Goncalves da Silva
Summary: Thiosemicarbazones derived from beta-lapachone showed potent cytotoxic effects on leukemia cells, with BV3 being the most selective compound, exhibiting high toxicity to tumor cells and low toxicity to normal cells. These compounds have the potential to be promising candidates for anticancer drugs.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Tai-Hsin Tsai, Kuan-Ting Lee, Yi-Chiang Hsu
Summary: Cucurbitacin I (JSI-124) derived from Cucurbitaceae has the potential to induce apoptosis and cell cycle arrest in glioblastoma multiforme (GBM) cells. JSI-124 effectively reduced cell viability in GBM cells, leading to apoptosis and cell cycle arrest.
Article
Multidisciplinary Sciences
Francisco J. Sanchez-Rivera, Jeremy Ryan, Yadira M. Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M. Feldser, Michael T. Hemann, Jesse Zamudio, Nadya Dimitrova, Anthony Letai, Tyler Jacks
Summary: The level of mitochondrial apoptotic priming is a critical determinant of cell fate upon p53 reactivation, with cells having high initial priming tending to undergo apoptosis and cells with low priming tending to survive and arrest in the cell cycle. Manipulating the priming levels through BCL-2 or BCL-XL expression or inhibition can affect the outcome of p53 restoration, highlighting mitochondrial apoptotic priming as a key factor in determining cell fate. Moreover, less primed cells can be forced into apoptotic cell fate following p53 activation using p53-independent drugs that increase apoptotic priming.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Seung-jae Kim, Huan J. Chang, Michael V. Volin, Sadiq Umar, Katrien Van Raemdonck, Aimee Chevalier, Karol Palasiewicz, John W. Christman, Suncica Volkov, Shiva Arami, Mehrdad Maz, Anjali Mehta, Ryan K. Zomorrodi, David A. Fox, Nadera Sweiss, Shiva Shahrara
CELLULAR & MOLECULAR IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Katrien Van Raemdonck, Sadiq Umar, Karol Palasiewicz, Suncica Volkov, Michael V. Volin, Shiva Arami, Huan J. Chang, Brian Zanotti, Nadera Sweiss, Shiva Shahrara
CELLULAR AND MOLECULAR LIFE SCIENCES
(2020)
Article
Immunology
Sadiq Umar, Karol Palasiewicz, Katrien Van Raemdonck, Michael V. Volin, Bianca Romay, M. Asif Amin, Ryan K. Zomorrodi, Shiva Arami, Mark Gonzalez, Vikram Rao, Brian Zanotti, David A. Fox, Nadera Sweiss, Shiva Shahrara
Summary: In this study, it was found that the binding of miR-Let7b to TLR7 can enhance synovitis, while IRAK4 inhibitor therapy can treat RA by reducing arthritis activity, especially in miR-Let7b-induced arthritis.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Katrien Van Raemdonck, Sadiq Umar, Shiva Shahrara
CYTOKINE & GROWTH FACTOR REVIEWS
(2020)
Article
Immunology
Mahmood Ahmad Khan, Abu Hasnath Md Golam Sarwar, Rani Rahat, Rafat Sultana Ahmed, Sadiq Umar
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Immunology
Katrien Van Raemdonck, Sadiq Umar, Karol Palasiewicz, Bianca Romay, Suncica Volkov, Shiva Arami, Nadera Sweiss, Shiva Shahrara
Summary: This study reveals that miR-Let7b activates TLR7 and induces skin inflammation, exacerbating joint inflammation in a PsA-like preclinical model. TLR7 agonist R837 promotes metabolic reprogramming in macrophages and enhances the expression of IL-1 beta, IL-6, and IL-12, facilitating myeloid-to-T-cell crosstalk in mice. Inhibiting glycolysis reverses TLR7-driven inflammation in myeloid and lymphoid cells, suggesting a potential therapeutic target for PsA.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Sadiq Umar, Karol Palasiewicz, Katrien Van Raemdonck, Michael V. Volin, Bianca Romay, Imran Ahmad, Chandana Tetali, Nadera Sweiss, M. Asif Amin, Ryan K. Zomorrodi, Shiva Shahrara
Summary: CCL25 and CCR9 enhance the infiltration and inflammatory response of RA FLS and monocytes in RA through p38 and ERK phosphorylation. However, CCL25 is unable to polarize RA PBMCs into effector Th1/Th17 cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Editorial Material
Chemistry, Multidisciplinary
Sadiq Umar, Mohamad Nasir Mohamad Ibrahim, Khalid Umar, Niyaz Ahmad
FRONTIERS IN CHEMISTRY
(2020)
Article
Rheumatology
Katrien Van Raemdonck, Sadiq Umar, Karol Palasiewicz, Michael V. Volin, Hatem A. Elshabrawy, Bianca Romay, Chandana Tetali, Azam Ahmed, M. Asif Amin, Ryan K. Zomorrodi, Nadera Sweiss, Shiva Shahrara
Summary: IL-34, an endogenous factor, plays a crucial role in rheumatoid arthritis by remodeling hypermetabolic M34 macrophages and facilitating their cross-regulation with T effector cells, ultimately leading to inflammatory bone destruction.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Immunology
Karol Palasiewicz, Sadiq Umar, Bianca Romay, Ryan K. Zomorrodi, Shiva Shahrara
Summary: The study showed that tofacitinib suppresses signaling, inflammation, and metabolic reprogramming caused by the Spike protein, suggesting it may be a promising strategy for COVID-19 patients.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sadiq Umar, Karol Palasiewicz, Michael V. Volin, Bianca Romay, Rani Rahat, Chandana Tetali, Shiva Arami, Monica Guma, Christian Ascoli, Nadera Sweiss, Ryan K. Zomorrodi, Luke A. J. O'Neill, Shiva Shahrara
Summary: Recent studies have shown the significance of metabolic reprogramming in immune and stromal cell function, and this study highlights the distinct regulation of glycolysis and oxidative phosphorylation in RA macrophages compared to fibroblasts. Blockade of glycolysis was found to be more effective than inhibition of complex 1 in CIA, particularly in mitigating the inflammatory phenotype of macrophages.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Katrien Van Raemdonck, Sadiq Umar, Karol Palasiewicz, Anja Meyer, Michael V. Volin, Huan J. Chang, Mina Al-Awqati, Ryan K. Zomorrodi, Shiva Shahrara
Summary: The study revealed the significant role of CCL21 in metabolic reprogramming of experimental arthritis and rheumatoid arthritis macrophages, and the mechanism of regulating inflammatory response through 2-DG therapy. The findings suggest that CCL21 promotes inflammation and impacts immune metabolism by modulating glucose uptake and glycolysis pathway.
IMMUNOLOGY AND CELL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Sadiq Umar, Karol Palasiewicz, Michael V. Volin, Brian Zanotti, Mina Al-Awqati, Nadera Sweiss, Shiva Shahrara
Summary: "Recent studies have shown a connection between glycolysis and inflammatory response in rheumatoid arthritis (RA) macrophages (M phi s) and fibroblasts (FLS). Targeting specific pathways, such as IRAK4i, can potentially rebalance the metabolic dysfunction in RA cells while modulating TLR7-mediated immunometabolism."
Article
Biochemistry & Molecular Biology
Sadiq Umar, Karol Palasiewicz, Anja Meyer, Prabhakaran Kumar, Bellur S. Prabhakar, Michael V. Volin, Rani Rahat, Mina Al-Awqati, Huan J. Chang, Ryan K. Zomorrodi, Jalees Rehman, Shiva Shahrara
Summary: Inflammatory and glycolytic responses in severe COVID-19 patients may be counter-regulated by targeting IRAK4, which plays a critical role in the molecular mechanism driven by SARS-CoV-2 Spike protein. Inhibition of IRAK4 rescues SARS-CoV-2-induced cytotoxic effects and reduces inflammatory markers and metabolic imprints, offering a promising therapeutic strategy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Retraction
Chemistry, Applied
Niyaz Ahmad, Md Aftab Alam, Rizwan Ahmad, Sadiq Umar, Farhan Jalees Ahmad
JOURNAL OF MICROENCAPSULATION
(2021)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.