Metabolic reprogramming of macrophages instigates CCL21‐induced arthritis

Rheumatoid arthritis CD14 + monocytes display metabolic and inflammatory dysfunction, a phenotype that precedes clinical manifestation of disease

(2021) Trudy McGarry et al.   Clinical & Translational Immunology

IL‐34 reprograms glycolytic and osteoclastic RA macrophages via Syndecan‐1 and M‐CSFR

(2021) Katrien Van Raemdonck et al.   Arthritis & Rheumatology

Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types

(2021) Sadiq Umar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosion

(2020) Sadiq Umar et al.   Cellular & Molecular Immunology

The pathogenic importance of CCL21 and CCR7 in rheumatoid arthritis

(2020) Katrien Van Raemdonck et al.   CYTOKINE & GROWTH FACTOR REVIEWS

CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis

(2019) Juan Liu et al.   IMMUNITY

CCL21/CCR7 signaling in macrophages promotes joint inflammation and Th17-mediated osteoclast formation in rheumatoid arthritis

(2019) Katrien Van Raemdonck et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration

(2018) Hannah Guak et al.   Nature Communications

Altered metabolic pathways regulate synovial inflammation in rheumatoid arthritis

(2018) U. Fearon et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Associations between CCL21 gene polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis

(2017) Guomin Li et al.   RHEUMATOLOGY INTERNATIONAL

Dysregulated bioenergetics: a key regulator of joint inflammation

(2016) M Biniecka et al.   ANNALS OF THE RHEUMATIC DISEASES

Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes

(2016) Ricard Garcia-Carbonell et al.   Arthritis & Rheumatology

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin

(2013) Marie Jaguin et al.   CELLULAR IMMUNOLOGY

Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort

(2012) John Bowes et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of the CCL21 and CCR7 pathways in rheumatoid arthritis angiogenesis

(2012) Sarah R. Pickens et al.   ARTHRITIS AND RHEUMATISM

Characterization of CCL19 and CCL21 in rheumatoid arthritis

(2011) Sarah R. Pickens et al.   ARTHRITIS AND RHEUMATISM

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited

(2010) Alexei Vazquez et al.   BMC Systems Biology