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Microbiology
Jehyun Jeon, Jaehee Lee, Se-Min Jung, Jae Hong Shin, Woon Ju Song, Mina Rho
Summary: This study conducted comprehensive sequence analysis and biochemical characterization of flavin-dependent halogenases (FDHs), discovering their essential genomic determinants and proposing a comprehensive set of sequence motifs related to active sites and regioselectivity based on large-scale genomic information. The research revealed that genomic patterns and phylogenetic locations determine the enzymatic reactivities of FDHs, which was experimentally validated in terms of substrate scope and regioselectivity, providing a foundation for future discovery and classification of novel FDHs. The study underscores the importance of accurately annotating and characterizing FDHs in protein sequence repositories to understand their functional activities.
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Biochemical Research Methods
Marta Casanellas, Jesus Fernandez-Sanchez, Marina Garrote-Lopez
Summary: SAQ is a phylogenetic quartet reconstruction method that is consistent with the most general Markov model of nucleotide substitution. By describing distributions through algebraic and semi-algebraic methods, it outputs normalized weights for trivalent quartets. SAQ outperforms most well known reconstruction methods on simulated data and data that violates assumptions.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2021)
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Ecology
Aaron A. King, Qianying Lin, Edward L. Ionides
Summary: This study constructs a family of genealogy-valued Markov processes based on a continuous-time Markov population process. Exact expressions for the likelihood of a given genealogy are derived conditional on the history of the underlying population process. The results lead to a nonlinear filtering equation that can be used to design efficient Monte Carlo inference algorithms.
THEORETICAL POPULATION BIOLOGY
(2022)
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Engineering, Electrical & Electronic
Zhangfeng Ma, Bo Ai, Ruisi He, Zhangdui Zhong, Mi Yang
Summary: A novel 3D non-stationary channel model is proposed for millimeter-wave UAV communications in this paper, considering both stationary and moving clusters and the dynamic properties of clusters. Numerical results show differences in time correlation and quasi-stationary interval between different components.
IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS
(2021)
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Statistics & Probability
Gyorgy H. Terdik
Summary: This paper provides clear formulae for the covariance functions of Laplacian ARMA fields in higher spatial dimensions using coefficients and Bessel functions. Spectral methods are used to study the spatiotemporal properties of Laplacian ARMA fields in Euclidean spaces and spheres with dimension d >= 2.
THEORY OF PROBABILITY AND MATHEMATICAL STATISTICS
(2022)
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Statistics & Probability
Manika Agarwal, Praveen Kumar Tripathi, Sarla Pareek
Summary: This paper analyzes the general autoregressive integrated moving average model under classical and Bayesian paradigms for forecasting infant mortality rate in India. Stationarity of a real data set is achieved through transformations and differencing, and the most appropriate model is selected using information criteria. Results are obtained using maximum likelihood estimators in classical framework and Bayesian analysis with vague priors is performed. Retrospective and prospective predictions for infant mortality rate show satisfactory results under both paradigms.
STATISTICS AND APPLICATIONS
(2021)
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Evolutionary Biology
Stephen M. Crotty, Bui Quang Minh, Nigel G. Bean, Barbara R. Holland, Jonathan Tuke, Lars S. Jermiin, Arndt von Haeseler
SYSTEMATIC BIOLOGY
(2020)
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Genetics & Heredity
Harriet R. Benbow, Lars S. Jermiin, Fiona M. Doohan
G3-GENES GENOMES GENETICS
(2019)
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Plant Sciences
Susanne Schilling, Alice Kennedy, Sirui Pan, Lars S. Jermiin, Rainer Melzer
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Multidisciplinary Sciences
David Jebb, Zixia Huang, Martin Pippel, Graham M. Hughes, Ksenia Lavrichenko, Paolo Devanna, Sylke Winkler, Lars S. Jermiin, Emilia C. Skirmuntt, Aris Katzourakis, Lucy Burkitt-Gray, David A. Ray, Kevin A. M. Sullivan, Juliana G. Roscito, Bogdan M. Kirilenko, Liliana M. Davalos, Angelique P. Corthals, Megan L. Power, Gareth Jones, Roger D. Ransome, Dina K. N. Dechmann, Andrea G. Locatelli, Sebastien J. Puechmaille, Olivier Fedrigo, Erich D. Jarvis, Michael Hiller, Sonja C. Vernes, Eugene W. Myers, Emma C. Teeling
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Evolutionary Biology
Corinna A. Pinzari, Lin Kang, Pawel Michalak, Lars S. Jermiin, Donald K. Price, Frank J. Bonaccorso
GENOME BIOLOGY AND EVOLUTION
(2020)
Article
Biochemical Research Methods
Tim W. McInerney, Brian Fulton-Howard, Christopher Patterson, Devashi Paliwal, Lars S. Jermiin, Hardip R. Patel, Judy Pa, Russell H. Swerdlow, Alison Goate, Simon Easteal, Shea J. Andrews
Summary: The study developed a reference alignment and pipeline, MitoImpute, to enhance the accuracy of imputing missing mtDNA single nucleotide variants (mtSNVs). Results showed significant improvement in haplogroup assignment and genotype concordance in samples from the 1000 Genomes Project and the ADNI cohort using MitoImpute, enabling broader functional and clinical investigation of mtDNA data.
BMC BIOINFORMATICS
(2021)
Article
Evolutionary Biology
Victor A. Vera-Ruiz, John Robinson, Lars S. Jermiin
Summary: In this study, a likelihood-ratio test for lumpability in DNA is introduced, which evaluates the retention of the Markovian property after recoding the nucleotides. The analysis of two data sets reveals that while recoding eliminates some compositional heterogeneity, it distorts the edge lengths in reconstructed trees by not retaining the original Markovian property.
SYSTEMATIC BIOLOGY
(2022)
Article
Genetics & Heredity
Liliya Doronina, Graham M. Hughes, Diana Moreno-Santillan, Colleen Lawless, Tadhg Lonergan, Louise Ryan, David Jebb, Bogdan M. Kirilenko, Jennifer M. Korstian, Liliana M. Davalos, Sonja C. Vernes, Eugene W. Myers, Emma C. Teeling, Michael Hiller, Lars S. Jermiin, Juergen Schmitz, Mark S. Springer, David A. Ray
Summary: The relationships among laurasiatherian clades are highly disputed in mammalian phylogeny. This study attempted to unravel these relationships using two independent genome-level approaches, but the results showed contradictory phylogenetic signals. The positions of some clades received consistent support, while the relationships of others were contradictory. Further research incorporating unsampled laurasiatherian lineages and synergistic analyses of different methods could help resolve these conflicting patterns.
Article
Genetics & Heredity
Letal Salzberg, Alexandre A. R. Martos, Lisa Lombardi, Lars S. Jermiin, Alfonso Blanco, Kevin P. Byrne, Kenneth H. Wolfe
Summary: We investigated the only known inversion polymorphism in S. cerevisiae, which affects a 24-kb 'flip/flop' region near the centromere of chromosome XIV. The inversion polymorphism is at least 17 million years old and is conserved across the genus Saccharomyces. The REF and INV isomers are not ancient alleles but are continually being re-created by re-inversion of the region within each species.
Correction
Evolutionary Biology
Victor A. Vera-Ruiz, John Robinson, Lars S. Jermiin
SYSTEMATIC BIOLOGY
(2022)
Article
Genetics & Heredity
Lars S. Jermiin, Renee A. Catullo, Barbara R. Holland
NAR GENOMICS AND BIOINFORMATICS
(2020)
Article
Genetics & Heredity
Thomas K. F. Wong, Subha Kalyaanamoorthy, Karen Meusemann, David K. Yeates, Bernhard Misof, Lars S. Jermiin
NAR GENOMICS AND BIOINFORMATICS
(2020)
Article
Biochemical Research Methods
John J. Dziak, Donna L. Coffman, Stephanie T. Lanza, Runze Li, Lars S. Jermiin
BRIEFINGS IN BIOINFORMATICS
(2020)
Correction
Biology
S. L. Pearce, D. F. Clarke, P. D. East, S. Elfekih, K. H. J. Gordon, L. S. Jermiin, A. McGaughran, J. G. Oakeshott, A. Papanicolaou, O. P. Perera, R. V. Rane, S. Richards, W. T. Tay, T. K. Walsh, A. Anderson, C. J. Anderson, S. Asgari, P. G. Board, A. Bretschneider, P. M. Campbell, T. Chertemps, J. T. Christeller, C. W. Coppin, S. J. Downes, G. Duan, C. A. Farnsworth, R. T. Good, L. B. Han, Y. C. Han, K. Hatje, I. Horne, Y. P. Huang, D. S. T. Hughes, E. Jacquin-Joly, W. James, S. Jhangiani, M. Kollmar, S. S. Kuwar, S. Li, N-Y. Liu, M. T. Maibeche, J. R. Miller, N. Montagne, T. Perry, J. Qu, S. V. Song, G. G. Sutton, H. Vogel, B. P. Walenz, W. Xu, H-J. Zhang, Z. Zou, P. Batterham, O. R. Edwards, R. Feyereisen, R. A. Gibbs, D. G. Heckel, A. McGrath, C. Robin, S. E. Scherer, K. C. Worley, Y. D. Wu
Article
Biology
S. L. Pearce, D. F. Clarke, P. D. East, S. Elfekih, K. H. J. Gordon, L. S. Jermiin, A. McGaughran, J. G. Oakeshott, A. Papanikolaou, O. P. Perera, R. V. Rane, S. Richards, W. T. Tay, T. K. Walsh, A. Anderson, C. J. Anderson, S. Asgari, P. G. Board, A. Bretschneider, P. M. Campbell, T. Chertemps, J. T. Christeller, C. W. Coppin, S. J. Downes, G. Duan, C. A. Farnsworth, R. T. Good, L. B. Han, Y. C. Han, K. Hatje, I. Horne, Y. P. Huang, D. S. T. Hughes, E. Jacquin-Joly, W. James, S. Jhangiani, M. Kollmar, S. S. Kuwar, S. Li, N-Y. Liu, M. T. Maibeche, J. R. Miller, N. Montagne, T. Perry, J. Qu, S. V. Song, G. G. Sutton, H. Vogel, B. P. Walenz, W. Xu, H-J. Zhang, Z. Zou, P. Batterham, O. R. Edwards, R. Feyereisen, R. A. Gibbs, D. G. Heckel, A. McGrath, C. Robin, S. E. Scherer, K. C. Worley, Y. D. Wu