Article
Biochemistry & Molecular Biology
Sai Krishna Srimadh Bhagavatham, Sujith Kumar Pulukool, Sai Sanwid Pradhan, R. Saiswaroop, Ashwin Ashok Naik, Datta V. M. Darshan, Venketesh Sivaramakrishnan
Summary: Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease. This study aimed to identify the critical pathways involved in RA pathophysiology through the analysis of transcriptomics, proteomics, and metabolomics datasets. The analysis revealed that SNPs associated with RA were categorized into pathways driving immune response and cytokine production. Further analysis identified gene expression and metabolic pathways with potential implications for RA.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemical Research Methods
Shan-Ju Yeh, Bor-Sen Chen
Summary: This study proposes a systematic approach to investigate the molecular progression mechanisms of gastric cancer and identifies critical biomarkers and corresponding drugs. By utilizing big database mining, system modeling, and deep learning techniques, the study successfully reveals the progression of gastric cancer and suggests potential multi-target drugs.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2022)
Article
Biochemistry & Molecular Biology
Wei Li, Tiandong Li, Chenguang Sun, Yimeng Du, Linna Chen, Chunyan Du, Jianxiang Shi, Weijie Wang
Summary: This study evaluated the highly and selectively expressed targets in pancreatic cancer (PC) using the GeoMxTM Digital Spatial Profiler (DSP) and analyzed their roles in PC using the TCGA database. LAMB3, FN1, KRT17, KRT19, and ANXA1 were identified as upregulated targets in PC and could be considered as predictors of prognosis and immunotherapy in PC.
MOLECULAR MEDICINE
(2022)
Review
Medicine, Research & Experimental
Hongyuan Liang, Lingyun Zhang, Jian Rong
Summary: The incidence and mortality rates of lung cancer (LC) are increasing globally each year. LC is difficult to detect early and easily metastasizes and relapses. Currently, there is no effective cure for advanced metastatic LC, leading to poor prognosis. Exosomes, nano-sized extracellular vesicles produced by healthy or diseased cells, contain various functional molecules and play crucial roles in the occurrence and metastasis of many malignancies, including LC. Understanding the potential roles of exosomes in the initiation, invasion, and metastasis of LC and the underlying molecular mechanisms could contribute to improved early diagnosis and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biology
Mahdie Mortezapour, Leili Tapak, Fatemeh Bahreini, Rezvan Najafi, Saeid Afshar
Summary: This study used bioinformatics tools to identify biomarkers and molecular factors involved in the diagnosis of colorectal cancer. Differential expression genes (DEGs) related to colorectal cancer (CRC) were determined using data from the GEO database. A weighted gene co-expression network analysis (WGCNA) was performed to explore co-expression modules related to CRC diagnosis. The study identified several hub genes and potential therapeutic agents for targeting CRC.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Akansha Srivastava, Palakkad Krishnanunni Vinod
Summary: In this study, the metabolic alterations of endometrial cancer (EC) were investigated to understand the variations in metabolism within tumor samples. Through integration of transcriptomics data and the human genome-scale metabolic network, metabolic subtypes of EC were identified, with each subtype displaying dysregulated metabolic pathways and reporter metabolites. The correlation between metabolic subtypes and clinical variables was explored, revealing significant associations with patient survival, tumor stages, mutation, and copy number variations.
Article
Oncology
William Lautert-Dutra, Camila M. Melo, Luiz P. Chaves, Francisco C. Souza, Cheryl Crozier, Adam E. Sundby, Elizabeth Woroszchuk, Fabiano P. Saggioro, Filipe S. Avante, Rodolfo B. dos Reis, Jeremy A. Squire, Jane Bayani
Summary: The diverse clinical outcomes of prostate cancer have led to the development of gene signature assays predicting disease progression. Improved prostate cancer progression biomarkers are needed as current RNA biomarker tests have varying success for intermediate prostate cancer. Interest grows in universal gene signatures for invasive carcinoma progression.
FRONTIERS IN ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Nerea Corbacho-Alonso, Tamara Sastre-Oliva, Cecilia Corros, Teresa Tejerina, Jorge Solis, Luis F. Lopez-Almodovar, Luis R. Padial, Laura Mourino-Alvarez, Maria G. Barderas
Summary: This study aims to investigate biomarkers for degenerative aortic stenosis through systems biology and artificial neuronal networks, and generate a panel of molecular biomarkers for accurate diagnosis, risk stratification, and follow-up of patients. The results suggest that two proteins related to endoplasmic reticulum stress, thrombospondin-1 and endoplasmin, may play an important role in aortic stenosis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemical Research Methods
Madhumita, Sushmita Paul
Summary: Identification of cancer subtypes is crucial for understanding tumor heterogeneity. This study proposes a novel method that combines feature weighting and similarity network fusion to identify cancer subtypes. The method is applied to three different cancer datasets and compared with existing methods, demonstrating its effectiveness.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2022)
Article
Multidisciplinary Sciences
Mina Shahnazari, Saeid Afshar, Mohammad Hassan Emami, Razieh Amini, Akram Jalali
Summary: This study aimed to evaluate and understand the unknown clinically relevant potential molecular biomarkers involved in colorectal cancer (CRC) from the inflammatory stage of ulcerative colitis (UC) to CRC metastasis, which can be suitable therapeutic targets. Through microarray data, differentially expressed genes (DEGs) and miRNAs (DEmiRNAs) were identified and used for robust rank aggregation (RRA) and co-expression network analysis. Finally, clinical samples were used to validate the potential and new target.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Karolina Seborova, Radka Vaclavikova, Lukas Rob, Pavel Soucek, Pavel Vodicka
Summary: Although advances have been made in cancer research, efficient predictive biomarkers for ovarian cancer progression and metastasis remain elusive. This review critically discusses recent findings on non-coding RNAs and DNA methylation as promising novel biomarkers in ovarian cancer. Identifying molecular changes in primary tumors and their metastases can help reveal the nature of metastatic development and provide early biomarkers for prognosis and disease progression. Regulatory elements from non-coding RNA families appear to play a role in these processes and may serve as potential molecular biomarkers for patient prognosis.
Article
Surgery
Sasha R. Douglas, Kay T. Yeung, Jing Yang, Sarah L. Blair, Olga Cohen, Brian P. Eliceiri
Summary: CD105 levels in EVs were significantly higher in participants with metastatic breast cancer compared to control participants. This suggests that EV-associated CD105 in plasma could serve as a potential biomarker for diagnosis, surveillance, and therapeutic targeting in patients with metastatic breast cancer.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Oncology
Pashtoon Murtaza Kasi, Griffin Budde, Michael Krainock, Vasily N. Aushev, Allyson Koyen Malashevich, Meenakshi Malhotra, Perry Olshan, Paul R. Billings, Alexey Aleshin
Summary: This study demonstrates the potential of immune checkpoint inhibitors in treating dMMR/MSI-H colorectal cancer. The case series shows that combination therapy with nivolumab and ipilimumab can achieve a durable response in patients who have progressed on pembrolizumab monotherapy. The use of ctDNA kinetics as a dynamic marker for therapy response assessment is supported by the findings.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Pharmacology & Pharmacy
Cristina Moreta-Moraleda, Cristina Queralt, Carla Vendrell-Ayats, Sonia Forcales, Eva Martinez-Balibrea
Summary: Colorectal cancer is the third most prevalent cancer globally and chemoresistance is the main cause of treatment failure. Epigenetic factors may serve as clinical biomarkers for colorectal cancer. In recent years, studies have investigated the relationship between chemotherapeutic treatment response and DNA methylation, histone modifications, and chromatin remodelers, but their exact relationship in colorectal cancer is still unclear.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shahram Parvin, Hamid Sedighian, Ehsan Sohrabi, Mahdieh Mahboobi, Milad Rezaei, Dariush Ghasemi, Ehsan Rezaei
Summary: This study reviewed candidate genes for lung cancer from 120 published articles, identifying potential genes like PLK1 that could be survival markers for patients. Through network and pathway analysis, new potential biomarkers for lung cancer were introduced, suggesting the importance of further studies and confirmatory tests for these genes.
BIOCHEMICAL GENETICS
(2022)
Article
Veterinary Sciences
Douglas H. Thamm, Kristen M. Weishaar, Joseph B. Charles, E. J. Ehrhart
VETERINARY AND COMPARATIVE ONCOLOGY
(2020)
Article
Veterinary Sciences
Douglas H. Thamm, Jenette K. Joseph, Barbara J. Rose, Travis K. Meuten, Kristen M. Weishaar
BMC VETERINARY RESEARCH
(2020)
Article
Veterinary Sciences
Corey F. Saba, Craig Clifford, Kristine Burgess, Brenda Phillips, David Vail, Zachary Wright, Katie Curran, Timothy Fan, Robyn Elmslie, Gerald Post, Douglas Thamm
VETERINARY AND COMPARATIVE ONCOLOGY
(2020)
Article
Veterinary Sciences
Giovanni Tremolada, Douglas H. Thamm, Milan Milovancev, Bernard Seguin
Summary: This study retrospectively evaluated the biological behavior and treatment outcomes of osteosarcoma affecting the digits, metatarsal, and metacarpal bones, showing that dogs with OSA in these locations may have a longer survival time compared to dogs with OSA in other appendicular locations.
VETERINARY AND COMPARATIVE ONCOLOGY
(2021)
Article
Veterinary Sciences
Zach Bohannan, Raghavendra Sumanth Pudupakam, Jamin Koo, Harrison Horwitz, Josephine Tsang, Amanda Polley, Enyang James Han, Elmer Fernandez, Stanley Park, Deanna Swartzfager, Nicholas Seah Xi Qi, Chantal Tu, Wendi Velando Rankin, Douglas H. Thamm, Hye-Ryeon Lee, Sungwon Lim
Summary: The study developed a precision medicine platform that evaluates chemotherapy drug efficacy for canine lymphoma by combining ex vivo chemosensitivity and immunophenotyping assays with computational modelling. The computational models successfully predicted positive treatment responses in different patient groups and may help improve treatment outcomes for individual canine lymphoma patients.
VETERINARY AND COMPARATIVE ONCOLOGY
(2021)
Editorial Material
Veterinary Sciences
Douglas H. Thamm
VETERINARY AND COMPARATIVE ONCOLOGY
(2021)
Article
Biology
Eshwar B. Udho, Shane M. Huebner, Dawn M. Albrecht, Kristina A. Matkowskyj, Linda Clipson, Catigan A. Hedican, Rachel Koth, Santina M. Snow, Emily L. Eberhardt, Devon Miller, Rachel Van Doorn, Genti Gjyzeli, Erin K. Spengler, Douglas R. Storts, Douglas H. Thamm, Elijah F. Edmondson, Michael M. Weil, Richard B. Halberg, Jeffery W. Bacher
Summary: The study compared the impact of exposure to galactic high-energy ions, gamma-ray radiation, or no radiation on mammary and liver cancer models, indicating that HZE radiation did not significantly increase tumor aggressiveness.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Oncology
Daniel L. Gustafson, Keagan P. Collins, Jared S. Fowles, E. J. Ehrhart, Kristen M. Weishaar, Sunetra Das, Dawn L. Duval, Douglas H. Thamm
Summary: The COXEN predictor of chemosensitivity to CARBO or DOX was not a significant predictor of progression-free interval or overall survival for the trial participants.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Veterinary Sciences
Erica A. Faulhaber, Emily Janik, Douglas H. Thamm
Summary: The study found that carboplatin chemotherapy after splenectomy for hemangiosarcoma in dogs yielded similar clinical outcomes to doxorubicin-based protocols. Additionally, an increase in postoperative peripheral monocyte counts may be associated with a poorer prognosis.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Review
Veterinary Sciences
Samuel A. Brill, Douglas H. Thamm
Summary: Adoptive cell transfer (ACT) is a promising therapeutic modality in human immuno-oncology, with novel approaches being developed rapidly in pre-clinical settings. While still in its infancy in veterinary medicine, canine ACT trials are progressing and may become a valuable tool for veterinary oncologists and translational researchers.
VETERINARY AND COMPARATIVE ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Jennifer M. Polinski, Aleksey V. Zimin, K. Fraser Clark, Andrea B. Kohn, Norah Sadowski, Winston Timp, Andrey Ptitsyn, Prarthana Khanna, Daria Y. Romanova, Peter Williams, Spencer J. Greenwood, Leonid L. Moroz, David R. Walt, Andrea G. Bodnar
Summary: The American lobster plays a crucial role in marine ecosystems and supports commercial fishing. It serves as a valuable model for studying neural networks and olfaction, with complex chemosensory and defense mechanisms contributing to its longevity and ecological success in the marine environment.
Article
Pathology
Brittany M. Wittenberns, Douglas H. Thamm, Eric P. Palmer, Daniel P. Regan
Summary: Splenic stromal sarcomas are rare with heterogeneous outcomes in dogs after treatment by splenectomy. Evaluating histopathology and immunohistochemistry is important to differentiate benign lesions from more aggressive malignancies in clinical diagnosis of splenic tumors.
JOURNAL OF COMPARATIVE PATHOLOGY
(2021)
Article
Veterinary Sciences
Johnny Altwal, Tiffany Wormhoudt Martin, Douglas H. Thamm, Bernard Seguin
Summary: This study evaluated 127 appendicular osteosarcoma sites in 122 dogs treated with SBRT, finding that the most common location for fractures during treatment was the distal tibia. Multiple types of fracture configurations were observed, with the distal radius being significantly more likely to develop a transverse fracture than other sites. Understanding the location and configuration of fractures is crucial for developing methods to reduce their occurrence.
VETERINARY AND COMPARATIVE ONCOLOGY
(2023)
Article
Veterinary Sciences
Jacob M. Siewert, Daniel L. Gustafson, Kristen M. Weishaar, Annie M. Galloway, Douglas H. Thamm
Summary: This study demonstrates that drug doses can be safely escalated in the 15-week CHOP protocol for dogs with multicentric lymphoma, with good treatment efficacy and manageable side effects.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
Barnaby Kelly, Douglas Thamm, Rhonda J. J. Rosengren
Summary: RL71, a synthetic analogue of curcumin, has potent anti-cancer activity in canine histiocytic sarcoma cells by inducing cell cycle arrest and apoptosis.
VETERINARY RESEARCH COMMUNICATIONS
(2023)