Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility, of chronic lymphocytic leukemia cells

Merlin-Deficient Human Tumors Show Loss of Contact Inhibition and Activation of Wnt/β-Catenin Signaling Linked to the PDGFR/Src and Rac/PAK Pathways

(2015) Lu Zhou et al.   NEOPLASIA

STAT3 mediates oncogenic addiction to TEL-AML1 in t(12;21) acute lymphoblastic leukemia

(2013) M. Mangolini et al.   BLOOD

Balanced Tiam1-Rac1 and RhoA Drives Proliferation and Invasion of Pancreatic Cancer Cells

(2013) Xingjun Guo et al.   MOLECULAR CANCER RESEARCH

CLL Cells Respond to B-Cell Receptor Stimulation with a MicroRNA/mRNA Signature Associated with MYC Activation and Cell Cycle Progression

(2013) Valerie Pede et al.   PLoS One

Coming full circle: 70 years of chronic lymphocytic leukemia cell redistribution, from glucocorticoids to inhibitors of B-cell receptor signaling

(2012) J. A. Burger et al.   BLOOD

RhoH is critical for cell-microenvironment interactions in chronic lymphocytic leukemia in mice and humans

(2012) A. Troeger et al.   BLOOD

Mimicking the microenvironment in chronic lymphocytic leukaemia - where does the journey go?

(2012) Daniela Asslaber et al.   BRITISH JOURNAL OF HAEMATOLOGY

CD40-Mediated Activation of Chronic Lymphocytic Leukemia Cells Promotes Their CD44-Dependent Adhesion to Hyaluronan and Restricts CCL21-Induced Motility

(2012) T. Girbl et al.   CANCER RESEARCH

Tiam1 is associated with hepatocellular carcinoma metastasis

(2012) Jing Huang et al.   INTERNATIONAL JOURNAL OF CANCER

Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase

(2012) Brenda L. Montalvo-Ortiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MGA, a suppressor ofMYC, is recurrently inactivated in high risk chronic lymphocytic leukemia

(2012) Lorenzo De Paoli et al.   LEUKEMIA & LYMPHOMA

Chronic lymphocytic leukemia and prolymphocytic leukemia with MYC translocations: a subgroup with an aggressive disease course

(2011) Natalie Put et al.   ANNALS OF HEMATOLOGY

The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity

(2011) R. Velaithan et al.   BLOOD

Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia

(2011) B. Mizukawa et al.   BLOOD

Nurse-like cells show deregulated expression of genes involved in immunocompetence

(2011) Nupur Bhattacharya et al.   BRITISH JOURNAL OF HAEMATOLOGY

Systematic review of purine analog treatment for chronic lymphocytic leukemia: lessons for future trials

(2011)   HAEMATOLOGICA

Methylation status of T-lymphoma invasion and metastasis 1 promoter and its overexpression in colorectal cancer

(2011) He Jin et al.   HUMAN PATHOLOGY

Rho GTPases: Masters of T lymphocyte migration and activation

(2011) Pablo Rougerie et al.   IMMUNOLOGY LETTERS

Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

(2011) Andrew W. Roberts et al.   JOURNAL OF CLINICAL ONCOLOGY

Clinical value of Tiam1–Rac1 signaling in primary gallbladder carcinoma

(2011) Xilin Du et al.   MEDICAL ONCOLOGY

Chronic lymphocytic leukemia: the pathologist's view of lymph node microenvironment

(2011) Maurilio Ponzoni et al.   SEMINARS IN DIAGNOSTIC PATHOLOGY

Nurture versus Nature: The Microenvironment in Chronic Lymphocytic Leukemia

(2011) J. A. Burger   Hematology-American Society of Hematology Education Program

Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis

(2010) E. E. Bosco et al.   BLOOD

A phase I, dose escalation study of lapatinib in combination with carboplatin, paclitaxel, with and without trastuzumab in patients with metastatic breast cancer.

(2010) A Storniolo et al.   CANCER RESEARCH

Modifying Akt Signaling in B-Cell Chronic Lymphocytic Leukemia Cells

(2010) S. W. Hofbauer et al.   CANCER RESEARCH

Rac and Rho GTPases in cancer cell motility control

(2010) Matteo Parri et al.   Cell Communication and Signaling

Rho GTPases in hematopoiesis and hemopathies

(2009) J. C. Mulloy et al.   BLOOD

The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration

(2009) A. Gerard et al.   BLOOD

Comparative Analysis of Normal versus CLL B-Lymphocytes Reveals Patient-Specific Variability in Signaling Mechanisms Controlling LFA-1 Activation by Chemokines

(2009) A. Montresor et al.   CANCER RESEARCH

Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility

(2009) Alok Tomar et al.   CURRENT OPINION IN CELL BIOLOGY

Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia

(2009) A Sanchez-Aguilera et al.   LEUKEMIA

Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

(2008) M. Vogler et al.   BLOOD

CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment

(2008) P. E. M. Patten et al.   BLOOD

Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration

(2008) J. Meller et al.   JOURNAL OF CELL SCIENCE

Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells

(2008) Pinella Buongiorno et al.   Molecular Cancer