Article
Cell Biology
Abhishek Singh, Shubhangini Tiwari, Sarika Singh
Summary: The study reveals the significant role of E3 ubiquitin ligase Pirh2 in regulating the aggregation of amyloid-beta protein in Alzheimer's disease. Pirh2 inhibits A beta aggregation by interacting with ER-chaperone GRP78, and improves neuronal morphology and connectivity.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Microbiology
Gilberto Betancor, Jose M. Jimenez-Guardeno, Steven Lynham, Robin Antrobus, Hataf Khan, Andrew Sobala, Matthew D. J. Dicks, Michael H. Malim
Summary: Dual functions of MX2 in innate immunity against HIV-1 and nuclear import of cellular proteins are regulated by phosphorylation. Interferon-stimulated genes establish an antiviral state by activating expression of antiviral cytokines. MX2 inhibits the nuclear import of HIV-1 through interactions with viral capsid and cellular transport machinery, with phosphorylation of its N-terminal domain regulating its antiviral activity and interactions. Interferon treatment reduces phosphorylation levels, highlighting a homeostatic regulatory mechanism balancing MX2's effects on normal cell function with immunity against HIV-1.
NATURE MICROBIOLOGY
(2021)
Article
Fisheries
Fei Peng, Saisai Jin, Zhaoyuan Chen, Haiyan Chang, Jun Xiao, Jianzhong Li, Jun Zou, Hao Feng
Summary: This study elucidated the role of black carp TRIF in antiviral signaling and discovered the interacting mechanisms with TRAF2 and TRAF6, which either up-regulate or down-regulate the antiviral activity of TRIF.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Shuang Wang, Yasuhiro Nemoto, Shigeru Oshima, Takeshi Tsubata, Takahiro Adachi, Yohei Kawano, Mamoru Watanabe, Richard S. Blumberg, Ryuichi Okamoto, Takashi Nagaishi
Summary: Research suggests that CEACAM1 can regulate mature B cell activation mediated by BCR, playing an important role in immune responses.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Zi-Yang Zhang, Dilshan S. Harischandra, Ruifang Wang, Shivani Ghaisas, Janet Y. Zhao, Thomas P. McMonagle, Guixin Zhu, Kenzo D. Lacuarta, Jianing Song, John Q. Trojanowski, Hong Xu, Virginia M. Y. Lee, Xiaolu Yang
Summary: The down-regulation of TRIM11 is implicated in the pathogenesis of tauopathies, and restoring TRIM11 expression can effectively ameliorate pathological changes and cognitive impairments in animal models of tauopathies.
Article
Biochemistry & Molecular Biology
Taewook Kang, Honggang Huang, Thomas Mandrup-Poulsen, Martin R. Larsen
Summary: Pro-inflammatory cytokines promote iron-import in pancreatic beta-cells through upregulation of divalent metal transporter-1 (DMT1), leading to cell death. Silencing of DMT1 protects against apoptosis in diabetes animal models by reversing IL-1 beta-induced phosphosites levels and inactivating autophagic flux, potentially improving beta-cell functions. This study sheds light on the signal transduction pathways involved in protecting beta-cells against inflammation-induced cell death after DMT1 silencing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ying Zhou, De-Mian Zhou, Wei-Wei Yu, Li-Li Shi, Yi Zhang, Yong-Xia Lai, Li-Ping Huang, Hua Qi, Qin-Fang Chen, Nan Yao, Jian-Feng Li, Li-Juan Xie, Shi Xiao
Summary: Phosphatidic acid modulates plant tolerance to submergence by affecting membrane integrity and MPK3/6-mediated hypoxia signaling.
Article
Immunology
Batya Isaacson, Maya Baron, Rachel Yamin, Gilad Bachrach, Francesca Levi-Schaffer, Zvi Granot, Ofer Mandelboim
Summary: CD300a plays a crucial role in the neutrophil-mediated immune response to UPEC-induced urinary tract infection. Deficiency of CD300a impairs phagocytic abilities of neutrophils, leading to severe exacerbation of infection.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jannik Jahn, Antonia Bollensdorf, Christopher Kalischer, Robin Piecha, Jana Weiss-Mueller, Phani Sankar Potru, Tamara Russ, Bjoern Spittau
Summary: It has been found that TGF beta regulates the activation of microglia by inhibiting the expression of Cd74 in these cells. Additionally, silencing of TGF beta signaling leads to upregulation of CD74, further demonstrating the importance of microglial TGF beta signaling in regulating microglia activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yingying Xu, Jiawang Tao, Xiaorui Yu, Yuhang Wu, Yan Chen, Kai You, Jiaye Zhang, Anteneh Getachew, Tingcai Pan, Yuanqi Zhuang, Fang Yuan, Fan Yang, Xianhua Lin, Yin-xiong Li
Summary: The study revealed that ASGR1 mutation led to decreased levels of non-HDL cholesterol and triglycerides in mice through the suppression of the SREBP signaling pathway. This finding suggests that the ASGR1/INSIG1/SREBP axis could be a potential target for lipid-lowering drug development.
Article
Biochemistry & Molecular Biology
Junwon Kim, Mark D. Rose
Summary: In Saccharomyces cerevisiae, the p21-activated kinase Cla4p regulates polarized morphogenesis and cytokinesis. Cla4p kinase activity is down-regulated during mating, and this is achieved through phosphorylation of Cla4p at multiple sites, including Cla4p-S186, which reduces its kinase activity. Fus3p counteracts Cla4p kinase activity during mating by phosphorylating Fus2p at different sites to promote nuclear export and block import.
Article
Biochemistry & Molecular Biology
Maria Mar Marques-Bueno, Laia Armengot, Lise C. Noack, Joseph Bareille, Lesia Rodriguez, Matthieu Pierre Platre, Vincent Bayle, Mengying Liu, Davy Opdenacker, Steffen Vanneste, Barbara K. Moller, Zachary L. Nimchuk, Tom Beeckman, Ana Cano-Delgado, Jiri Friml, Yvon Jaillais
Summary: Plants can adjust their growth direction according to gravity by utilizing asymmetric distribution of the plant hormone auxin, which is dependent on the activity of polarly localized PIN-FORMED (PIN) auxin-efflux carriers.
Article
Biochemistry & Molecular Biology
Gangli Yan, Zhiwei Tao, Xiaobing Xing, Ziying Zhou, Xinghua Wang, Xing Li, Fengguang Li
Summary: This study investigates the role of miR-192-5p in hypoxic-ischemic brain damage (HIBD) and its relationship with the Yes-associated protein 1 (YAP1)-mediated Hippo signaling pathway. The findings suggest that inhibiting miR-192-5p or overexpressing YAP1 can alleviate neurobehavioral impairment and neuronal damage in HIBD.
NEUROCHEMICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yuanyuan Liu, Wenshan Zhong, Jinming Zhang, Weimou Chen, Ye Lu, Yujie Qiao, Zhaojin Zeng, Haohua Huang, Shaoxi Cai, Hangming Dong
Summary: The study found that tetrandrine could inhibit the expression of fibrotic markers induced by TGF-beta 1, suppress fibroblast proliferation, and restore impaired autophagy flux. These effects may be mediated through promoting Rheb-mTOR and NRF2-SQSTM1-mediated autophagy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Ericka Martinez-Martinez, Victor Hugo Sanchez-Vazquez, Daniel Leon-Aparicio, Jose Sanchez-Collado, Martin-Leonardo Gallegos-Gomez, Juan A. Rosado, Juan M. Arias, Agustin Guerrero-Hernandez
Summary: This study found that overexpression of the Orai1 channel inhibits calcium ion release from the endoplasmic reticulum (ER), but in the presence of external calcium ions, HeLa cells overexpressing the Orai1 channel displayed increased calcium ion entry and limited ER depletion in response to the combination of ATP and thapsigargin (TG). The phosphorylation of Orai1 at S27/30 residues regulates this process by reducing IP3R-mediated calcium ion release.
Review
Oncology
Inigo Terren, Ane Orrantia, Idoia Mikelez-Alonso, Joana Vitalle, Olatz Zenarruzabeitia, Francisco Borrego
Article
Immunology
Joana Vitalle, Laura Tarancon-Diez, Maria R. Jimenez-Leon, Inigo Terren, Ane Orrantia, Cristina Roca-Oporto, Luis Lopez-Cortes, Ezequiel Ruiz-Mateos, Olatz Zenarruzabeitia, Francisco Borrego
Review
Biochemistry & Molecular Biology
Joana Vitalle, Inigo Terren, Ane Orrantia, Agurtzane Bilbao, Pedro M. Gamboa, Francisco Borrego, Olatz Zenarruzabeitia
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Joana Vitalle, Inigo Terren, Leire Gamboa-Urquijo, Ane Orrantia, Laura Tarancon-Diez, Miguel Genebat, Manuel Leal, Ezequiel Ruiz-Mateos, Francisco Borrego, Olatz Zenarruzabeitia
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Ane Orrantia, Inigo Terren, Alicia Izquierdo-Lafuente, Juncal A. Alonso-Cabrera, Victor Sanda, Joana Vitalle, Santiago Moreno, Maria Tasias, Alasne Uranga, Carmen Gonzalez, Juan J. Mateos, Juan C. Garcia-Ruiz, Olatz Zenarruzabeitia, Francisco Borrego
Letter
Allergy
Christina L. Pranger, Judit Fazekas-Singer, Verena K. Koehler, Isabella Pali-Schoell, Alessandro Fiocchi, Sophia N. Karagiannis, Olatz Zenarruzabeitia, Francisco Borrego, Erika Jensen-Jarolim
Article
Hematology
Inigo Terren, Ane Orrantia, Joana Vitalle, Gabirel Astarloa-Pando, Olatz Zenarruzabeitia, Francisco Borrego
SEMINARS IN HEMATOLOGY
(2020)
Article
Immunology
Olatz Zenarruzabeitia, Gabirel Astarloa-Pando, Inigo Terren, Ane Orrantia, Raquel Perez-Garay, Iratxe Seijas-Betolaza, Javier Nieto-Arana, Natale Imaz-Ayo, Silvia Perez-Fernandez, Eunate Arana-Arri, Francisco Borrego
Summary: This study analyzed the immune system status of patients with different severity of COVID-19, finding that severe cases exhibit higher activation levels in various T cell subsets, increased expression of immune markers in cytotoxic cells, and accumulation of dysfunctional monocytes. The study also showed a strong association between immune cell alterations and clinical signs of severity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Inigo Terren, Ane Orrantia, Alba Mosteiro, Joana Vitalle, Olatz Zenarruzabeitia, Francisco Borrego
Summary: NK cells acquire memory-like properties following stimulation with IL-12, IL-15 and IL-18, and these cytokine-induced memory-like NK cells have shown promising potential in cancer immunotherapy. NK cells modulate their metabolism in response to cytokine-stimulation, with a link between metabolism and cellular functions.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Ane Orrantia, Inigo Terren, Gabirel Astarloa-Pando, Olatz Zenarruzabeitia, Francisco Borrego
Summary: NK cells are important components of the innate immune system that play a key role in tumor immunosurveillance. While the therapeutic potential of NK cells in allogeneic HSCT is well recognized, their significance and effects on outcomes in autologous HSCT are less understood. This review summarizes the diverse functions and roles of NK cells in different HSCT settings.
Review
Pharmacology & Pharmacy
Idoia Mikelez-Alonso, Susana Magadan, Africa Gonzalez-Fernandez, Francisco Borrego
Summary: NK cells are lymphocytes with potent antitumor and antiviral functions, exhibiting memory-like responses. Various NK cell-based immunotherapies have been developed, with nanotechnology considered as an attractive option to enhance NK cell effector functions.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Pharmacology & Pharmacy
Susana Magadan, Idoia Mikelez-Alonso, Francisco Borrego, Africa Gonzalez-Fernandez
Summary: Recent studies have shown that innate immune cells can exhibit changes in their functional programs after infection or vaccination, leading to trained immunity or innate immune memory, distinct from the specific memory immune response by B and T lymphocytes. The review mainly focuses on myeloid cells in trained immunity, pathogen recognition in evolution, and techniques for studying epigenetic reprogramming and metabolic rewiring. Nanomaterials offer a promising avenue to understand trained immunity and can be modified to modulate immune responses.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Immunology
Ane Orrantia, Inigo Terren, Gabirel Astarloa-Pando, Carmen Gonzalez, Alasne Uranga, Juan J. Mateos-Mazon, Juan C. Garcia-Ruiz, Marta Rinon, Mercedes Rey, Silvia Perez-Fernandez, Olatz Zenarruzabeitia, Francisco Borrego
Summary: AutoHSCT in MM patients leads to significant changes in NK cell subsets and phenotype, with patients showing lower frequencies of the mature NKG2A-CD57+ NK cell subset experiencing better clinical outcomes. This suggests that the degree of NK cell maturation post-autoHSCT affects the disease progression and treatment outcomes in MM patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Meeting Abstract
Allergy
C. L. Pranger, J. F. Singer, V. K. Koehler, I. Pali-Schoell, A. Fiocchi, S. N. Karagiannis, O. Zenarruzabeitia, F. Borrego, E. Jensen-Jarolim
Article
Biochemical Research Methods
Ane Orrantia, Inigo Terren, Joana Vitalle, Gabirel Astarloa-Pando, Olatz Zenarruzabeitia, Francisco Borrego