Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor

Adoptive Transfer of Gene-Modified Primary NK Cells Can Specifically Inhibit Tumor Progression In Vivo

(2014) H. J. Pegram et al.   JOURNAL OF IMMUNOLOGY

IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice

(2010) J. C. Markley et al.   BLOOD

Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation

(2010) K. P. Micklethwaite et al.   BLOOD

Adoptive T cell therapy of cancer

(2010) Malcolm K Brenner et al.   CURRENT OPINION IN IMMUNOLOGY

Genetic redirection of T cells for cancer therapy

(2010) Jennifer A. Westwood et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety

(2010) V Hoyos et al.   LEUKEMIA

Safer CARS

(2010) Helen E Heslop   MOLECULAR THERAPY

Treatment of Chronic Lymphocytic Leukemia With Genetically Targeted Autologous T Cells: Case Report of an Unforeseen Adverse Event in a Phase I Clinical Trial

(2010) Renier Brentjens et al.   MOLECULAR THERAPY

A Transposon and Transposase System for Human Application

(2010) Perry B Hackett et al.   MOLECULAR THERAPY

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice

(2009) S. E. James et al.   BLOOD

Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system

(2009) X. Xue et al.   BLOOD

T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model

(2009) A. Di Stasi et al.   BLOOD

Recognition and Killing of Brain Tumor Stem-Like Initiating Cells by CD8+ Cytolytic T Cells

(2009) C. E. Brown et al.   CANCER RESEARCH

Expansion of Highly Cytotoxic Human Natural Killer Cells for Cancer Cell Therapy

(2009) H. Fujisaki et al.   CANCER RESEARCH

Persuading Natural Killer Cells to Eliminate Bad B Cells

(2009) L. J.N. Cooper   CLINICAL CANCER RESEARCH

Immunotherapy of Metastatic Melanoma Using Genetically Engineered GD2-Specific T cells

(2009) E. Yvon et al.   CLINICAL CANCER RESEARCH

Immunotherapy of Human Cancers Using Gene Modified T Lymphocytes

(2009) Juan Vera et al.   CURRENT GENE THERAPY

The promise and potential pitfalls of chimeric antigen receptors

(2009) Michel Sadelain et al.   CURRENT OPINION IN IMMUNOLOGY

Expression of IL-15RA or an IL-15/IL-15RA fusion on CD8+ T cells modifies adoptively transferred T-cell function in cis

(2009) Jesse Rowley et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Treatment of lymphoma with adoptively transferred T cells

(2009) Brian G Till et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Re-targeting T-cells against cancer by gene-transfer of tumor-reactive receptors

(2009) Victoria Marcu-Malina et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Retroviral transfer of human CD20 as a suicide gene for adoptive T-cell therapy

(2009) M. Griffioen et al.   HAEMATOLOGICA

Fifteen Years of Gene Therapy Based on Chimeric Antigen Receptors: “Are We Nearly There Yet?”

(2009) Gianpietro Dotti et al.   HUMAN GENE THERAPY

piggyBac Transposon/Transposase System to Generate CD19-Specific T Cells for the Treatment of B-Lineage Malignancies

(2009) Pallavi V. Raja Manuri et al.   HUMAN GENE THERAPY

A Panel of Artificial APCs Expressing Prevalent HLA Alleles Permits Generation of Cytotoxic T Cells Specific for Both Dominant and Subdominant Viral Epitopes for Adoptive Therapy

(2009) A. N. Hasan et al.   JOURNAL OF IMMUNOLOGY

A Herceptin-Based Chimeric Antigen Receptor with Modified Signaling Domains Leads to Enhanced Survival of Transduced T Lymphocytes and Antitumor Activity

(2009) Y. Zhao et al.   JOURNAL OF IMMUNOLOGY

Manufacturing Validation of Biologically Functional T Cells Targeted to CD19 Antigen for Autologous Adoptive Cell Therapy

(2009) Daniel Hollyman et al.   JOURNAL OF IMMUNOTHERAPY

Optimization of the PiggyBac Transposon System for the Sustained Genetic Modification of Human T Lymphocytes

(2009) Yozo Nakazawa et al.   JOURNAL OF IMMUNOTHERAPY

Construction and Preclinical Evaluation of an Anti-CD19 Chimeric Antigen Receptor

(2009) James N. Kochenderfer et al.   JOURNAL OF IMMUNOTHERAPY

Increased Intensity Lymphodepletion Enhances Tumor Treatment Efficacy of Adoptively Transferred Tumor-specific T Cells

(2009) Claudia Wrzesinski et al.   JOURNAL OF IMMUNOTHERAPY

Modulating T-cell homeostasis with IL-7: preclinical and clinical studies

(2009) C. M. Capitini et al.   JOURNAL OF INTERNAL MEDICINE

Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I–II study

(2009) Fabio Ciceri et al.   LANCET ONCOLOGY

Transfection with mRNA for CD19 specific chimeric antigen receptor restores NK cell mediated killing of CLL cells

(2009) Laurent Boissel et al.   LEUKEMIA RESEARCH

Efficient stable gene transfer into human cells by the Sleeping Beauty transposon vectors

(2009) Z IZSVAK   METHODS

Transgene Expression Levels Determine the Immunogenicity of Transduced Hematopoietic Grafts in Partially Myeloablated Mice

(2009) Herena Eixarch et al.   MOLECULAR THERAPY

Risk in Clinical Research: Size Matters!

(2009) Pedro R Lowenstein   MOLECULAR THERAPY

Genetic Manipulation of Tumor-specific Cytotoxic T Lymphocytes to Restore Responsiveness to IL-7

(2009) Juan F Vera et al.   MOLECULAR THERAPY

Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo

(2009) Michael C. Milone et al.   MOLECULAR THERAPY

Loss of Mismatched HLA in Leukemia after Stem-Cell Transplantation

(2009) Luca Vago et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fludarabine Modulates Immune Response and Extends In Vivo Survival of Adoptively Transferred CD8 T Cells in Patients with Metastatic Melanoma

(2009) Herschel Wallen et al.   PLoS One

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity

(2009) C. S. Hinrichs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adoptive immunotherapy for cancer: the next generation of gene-engineered immune cells

(2009) L. J. Berry et al.   TISSUE ANTIGENS

Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow

(2008) U. Palendira et al.   BLOOD

Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells

(2008) B. G. Till et al.   BLOOD

Redirecting Specificity of T-Cell Populations For CD19 Using the Sleeping Beauty System

(2008) H. Singh et al.   CANCER RESEARCH

Zoledronate facilitates large-scale ex vivo expansion of functional γδ T cells from cancer patients for use in adoptive immunotherapy*

(2008) M. Kondo et al.   CYTOTHERAPY

Adoptive Cell Therapy for Patients with Melanoma, Using Tumor-Infiltrating Lymphocytes Genetically Engineered to Secrete Interleukin-2

(2008) Bianca Heemskerk et al.   HUMAN GENE THERAPY

Genetic engineering of T cells for adoptive immunotherapy

(2008) Angel Varela-Rohena et al.   IMMUNOLOGIC RESEARCH

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

(2008) Carolina Berger et al.   JOURNAL OF CLINICAL INVESTIGATION

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

(2008) Salima Hacein-Bey-Abina et al.   JOURNAL OF CLINICAL INVESTIGATION

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

(2008) Claude Sportès et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selective expansion of genetically modified T cells using an antibody/interleukin-2 receptor chimera

(2008) Takahiro Sogo et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Monitoring the Efficacy of Adoptively Transferred Prostate Cancer-Targeted Human T Lymphocytes with PET and Bioluminescence Imaging

(2008) K. Dobrenkov et al.   JOURNAL OF NUCLEAR MEDICINE

PET imaging of T cells derived from umbilical cord blood

(2008) H Singh et al.   LEUKEMIA

Sleeping Beauty Vector System Moves Toward Human Trials in the United States

(2008) David A Williams   MOLECULAR THERAPY

Sleeping Beauty Transposon‐mediated Engineering of Human Primary T Cells for Therapy of CD19+ Lymphoid Malignancies

(2008) Xin Huang et al.   MOLECULAR THERAPY

Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors

(2008) Johannes L Zakrzewski et al.   NATURE BIOTECHNOLOGY

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

(2008) Martin A Pule et al.   NATURE MEDICINE

Noninvasive detection of therapeutic cytolytic T cells with 18F–FHBG PET in a patient with glioma

(2008) Shahriar S Yaghoubi et al.   Nature clinical practice. Oncology