期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 87, 期 5, 页码 791-803出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.1209824
关键词
adoptive immunotherapy; chimeric receptor; tumor; retroviral vector; lentiviral vector; TCR
资金
- National Health and Medical Research Council of Australia (NHMRC)
- Cancer Council of Victoria
- Susan G. Komen Breast Cancer Foundation
- Bob Parker Memorial Trust
- Peter MacCallum Cancer Centre Foundation
Adoptive immunotherapy can induce dramatic tumor regressions in patients with melanoma or viral-induced malignancies, but extending this approach to many common cancers has been hampered by a lack of naturally occurring tumor-specific T cells. In this review, we describe recent advances in the genetic modification of T cells using genes encoding cell-surface receptors specific for tumor-associated antigen. Using genetic modification, the many functional properties of T cells, including cytokine secretion and cytolytic capacity, are redirected from their endogenous specificity toward the elimination of tumor cells. Advances in gene design, vectors, and cell production are discussed, and details of the progress in clinical application of this approach are provided. J. Leukoc. Biol. 87: 791-803; 2010.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据