Review
Biochemistry & Molecular Biology
Jinmi Zou, Frauke Swieringa, Bas de Laat, Philip G. de Groot, Mark Roest, Johan W. M. Heemskerk
Summary: This paper reviews the functional reversibility of integrin alpha IIb beta 3 activation and transient aggregation and discusses the signaling pathways involved. The study finds that ADP P2Y(1) and P2Y(12) receptor signaling via phosphoinositide 3-kinases and Akt are the principal pathways linked to reversible integrin activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Xiamin Wang, Guangyu Wei, Yangyang Ding, Xiang Gui, Huan Tong, Xiaoqi Xu, Sixuan Zhang, Zengtian Sun, Wen Ju, Yue Li, Ruosi Yao, Qingyu Wu, Zhihao Lu, Chunling Fu, Zhenyu Li, Si Zhang, Elizabeth E. Gardiner, Robert K. Andrews, Hu Hu, Lingyu Zeng, Jianlin Qiao, Kailin Xu
Summary: This study reveals a novel role of protein tyrosine phosphatase nonreceptor type 22 (PTPN22) in platelet function and arterial thrombosis, identifying new potential targets for future prevention of thrombotic or cardiovascular diseases.
Article
Gastroenterology & Hepatology
Yu-Hsuan Lin, Qiyu Zeng, Yuemeng Jia, Zixi Wang, Lin Li, Meng-Hsiung Hsieh, Qiang Cheng, Chase A. Pagani, Nicholas Livingston, Jeon Lee, Yu Zhang, Tripti Sharma, Daniel J. Siegwart, Dean Yimlamai, Benjamin Levi, Hao Zhu
Summary: Using an in vivo CRISPR screening system, the study identified SPP2 as a secreted factor that negatively regulates liver regeneration. The results provide a method to identify, validate, and characterize secreted factors in vivo.
Article
Hematology
Fahd A. Kuriri, Genia Burchall, Fehaid Alanazi, Juliana Antonipillai, Gasim Dobie, Nicole Beachemin, Denise E. Jackson
Summary: This study demonstrates the combined negative regulatory role of PECAM-1 and CEACAM1 in platelet activation and thrombus formation.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Charlie A. Coupland, Leigh Naylor-Adamson, Zoe Booth, Thomas W. Price, Helio M. Gil, George Firth, Michelle Avery, Yusra Ahmed, Graeme J. Stasiuk, Simon D. J. Calaminus
Summary: Approximately 17.3% of the global population suffers from zinc (Zn2+) deficiency, which leads to increased bleeding due to impaired hemostasis. Zinc ion (Zn2+) has the ability to modulate platelet signaling through the endothelial-derived prostacyclin I2 (PGI2) pathway, affecting thrombus formation and hemostasis.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cell Biology
Madeleine Goeritzer, Stefanie Schlager, Katharina B. Kuentzel, Nemanja Vujic, Melanie Korbelius, Silvia Rainer, Dagmar Kolb, Marion Mussbacher, Manuel Salzmann, Waltraud C. Schrottmaier, Alice Assinger, Axel Schlagenhauf, Corina T. Madreiter-Sokolowski, Sandra Blass, Thomas O. Eichmann, Wolfgang F. Graier, Dagmar Kratky
Summary: Loss of ATGL in platelets is associated with an anti-thrombogenic phenotype without pathological bleeding and platelet activation.
Article
Cell Biology
Kahdr A. Alatawi, Divyashree Ravishankar, Pabitra H. Patra, Alexander P. Bye, Alexander R. Stainer, Ketan Patel, Darius Widera, Sakthivel Vaiyapuri
Summary: 1,8-cineole has shown inhibitory effects on platelet activation, thrombus formation, and hemostasis, affecting platelet signaling pathways, granule secretion, and intracellular calcium mobilization. It may act as a potential therapeutic agent to control unwarranted platelet reactivity under various pathophysiological settings.
Article
Biochemistry & Molecular Biology
Isabella Provenzale, Ilaria De Simone, Jonathan M. Gibbins, Johan W. M. Heemskerk, Paola E. J. van der Meijden, Chris I. Jones
Summary: This study investigated the roles of different extracellular matrix proteoglycans in platelet responses and thrombus formation. It was found that one proteoglycan (perlecan) enhanced platelet activation and promoted thrombus formation, but also reduced platelet adhesion under flow. This suggests that proteoglycans play an important role in platelet activation and thrombus formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Ji Hye Kim, Jae Gwang Park, Yo Han Hong, Kon Kuk Shin, Jin Kyeong Kim, Young-Dong Kim, Ki Dong Yoon, Kyung-Hee Kim, Byong Chul Yoo, Gi-Ho Sung, Jae Youl Cho
Summary: The study found that Sb-EE from Sauropus brevipes Mull. Arg. effectively suppressed nitric oxide release and modulated inflammatory responses in various inflammation models, indicating its potential as an anti-inflammatory agent.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Qing Guan, Ze-hong Guo, Da-mao Dai, Zhe-xiang Fan, Jian Chen, Shu-lin Wu, Xiao-min Liu, Yong Miao, Zhi-qi Hu, Qian Qu
Summary: This study investigates the mechanisms of platelet lysate (PL) in promoting hair growth through animal models, organ-cultured hair follicles, and RNA-seq analysis. A randomized, controlled, double-blind study with 107 AGA patients confirms the therapeutic efficacy of PL in improving hair quality. The study concludes that PL has specific molecular mechanisms in promoting hair growth and exhibits similar effects compared to PRP in AGA patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Jiajia Liu, Benhui Shi, Mengxin Zhang, Guangchao Liu, Zhaojun Ding, Huiyu Tian
Summary: Soluble aluminum (Al) is a major constraint to crop production in acidic soils. The Al exclusion mechanism, correlated with Al-induced organic acid, is considered important for Al resistance. This study identifies the unknown gene TZ1 as an Al-inducible gene in the root transition zone of Arabidopsis. TZ1 negatively regulates root growth response to Al stress through interacting with ACOs and regulating citric acid homeostasis.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Kailiang Li, Djeneba Diakite, Julia Austin, Jung-Ho Lee, Daniel D. Lantvit, Brian T. Murphy, Joanna E. Burdette
Summary: Baicalein functions as a PR antagonist in vivo and attenuates the antiproliferative effect of P4 on luminal epithelium, while not changing levels of PR or GR RNA or protein in the uterus. RNA sequencing data suggest that transcripts significantly altered by baicalein are regulated in the opposite direction by P4, indicating potential opposing effects of baicalein and P4 in the uterus.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Daisuke Mizutani, Haruhiko Tokuda, Takashi Onuma, Kodai Uematsu, Daiki Nakashima, Kyohei Ueda, Tomoaki Doi, Yukiko Enomoto, Rie Matsushima-Nishiwaki, Shinji Ogura, Hiroki Iida, Osamu Kozawa, Toru Iwama
Summary: Amyloid beta protein negatively regulates human platelet activation, which may contribute to intracerebral hemorrhage.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2022)
Article
Anesthesiology
Michael Schoerghuber, Thomas Baernthaler, Florian Prueller, Polina Mantaj, Gerhard Cvirn, Wolfgang Toller, Christoph Klivinyi, Elisabeth Mahla, Akos Heinemann
Summary: Moderately hypothermic cardiopulmonary bypass during cardiac surgery induces platelet dysfunction, which can be restored by supplemental fibrinogen.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Agriculture, Multidisciplinary
Yijie Yang, Bo Li
Summary: Collagen peptide DEGP was found to inhibit platelet aggregation and thrombus formation, and regulate phosphorylation processes by antagonizing TP and P2Y12 receptors. Among them, DEGI exhibited the strongest inhibitory activity against platelet aggregation and antithrombotic activity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Hematology
Li Ma, Elisa Simpson, June Li, Min Xuan, Miao Xu, Laura Baker, Yan Shi, Issaka Yougbare, Xiaozhong Wang, Guangheng Zhu, Pingguo Chen, Gerald J. Prud'homme, Alan H. Lazarus, John Freedman, Heyu Ni
Article
Hematology
Li Guo, Rick Kapur, Rukshana Aslam, Edwin R. Speck, Anne Zufferey, Yajing Zhao, Michael Kim, Alan H. Lazarus, Heyu Ni, John W. Semple
Editorial Material
Hematology
Yiming Wang, Heyu Ni
Review
Biochemistry & Molecular Biology
Yiming Wang, Heyu Ni
CELLULAR AND MOLECULAR LIFE SCIENCES
(2016)
Review
Medical Laboratory Technology
Xiaohong Ruby Xu, Dan Zhang, Brigitta Elaine Oswald, Naadiya Carrim, Xiaozhong Wang, Yan Hou, Qing Zhang, Christopher Lavalle, Thomas McKeown, Alexandra H. Marshall, Heyu Ni
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2016)
Review
Hematology
Yiming Wang, Reid C. Gallant, Heyu Ni
CURRENT OPINION IN HEMATOLOGY
(2016)
Article
Endocrinology & Metabolism
Alison Cameron-Vendrig, Adili Reheman, M. Ahsan Siraj, Xiaohong Ruby Xu, Yiming Wang, Xi Lei, Talat Afroze, Eric Shikatani, Omar El-Mounayri, Hossein Noyan, Ralph Weissleder, Heyu Ni, Mansoor Husain
Review
Pediatrics
Darko Zdravic, Issaka Yougbare, Brian Vadasz, Conglei Li, Alexandra H. Marshall, Pingguo Chen, Jens Kjeldsen-Kragh, Heyu Ni
SEMINARS IN FETAL & NEONATAL MEDICINE
(2016)
Article
Hematology
Xiaohong Ruby Xu, George M. Yousef, Heyu Ni
Article
Multidisciplinary Sciences
Jihua Qiu, Xuena Liu, Xiaoqing Li, Xu Zhang, Panpan Han, Hai Zhou, Linlin Shao, Yu Hou, Yanan Min, Zhangyuan Kong, Yawen Wang, Yu Wei, Xinguang Liu, Heyu Ni, Jun Peng, Ming Hou
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Louise J. Eltringham-Smith, Ruoying Yu, Syed M. Qadri, Yiming Wang, Varsha Bhakta, Edward L. Pryzdial, Jeffrey R. Crosby, Heyu Ni, William P. Sheffield
SCIENTIFIC REPORTS
(2019)
Article
Hematology
Alexander Leatherdale, D'Andra Parker, Subia Tasneem, Yiming Wang, Dominique Bihan, Arkadiusz Bonna, Samir W. Hamaia, Peter L. Gross, Heyu Ni, Bradley W. Doble, David Lillicrap, Richard W. Farndale, Catherine P. M. Hayward
Summary: Multimerin 1 enhances platelet adhesion synergistically with other triple-helical collagen peptides by binding to highly conserved GPAGPOGPX motifs in fibrillar collagens. Moreover, Mmrn1-deficient mice showed impaired platelet adhesion and thrombus formation in the ferric chloride injury model.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Peter A. A. Norris, Gurleen Kaur, Ramsha Khan, Guangheng Zhu, Heyu Ni, Alan H. Lazarus
Summary: Anti-CD44 exhibits anti-inflammatory effects in murine ITP by inhibiting macrophage phagocytosis through blockade of Fc gamma R, potentially serving as an alternative to IVIg. The specific Fc gamma R blockade mechanism of anti-CD44 contributes to its therapeutic efficacy in ITP models, highlighting its potential as a treatment option.
Article
Biochemistry & Molecular Biology
Ming Liu, Gan Wang, Runjia Xu, Chuanbin Shen, Heyu Ni, Ren Lai
Summary: Soy isoflavones genistein and daidzein were found to inhibit thrombosis formation, particularly under high shear force. They interact with 14-3-3ζ and suppress multiple platelet activation pathways and outside-in signaling transduction. These findings suggest that 14-3-3ζ is a novel target for genistein and daidzein in platelet inhibition.
Article
Chemistry, Medicinal
Wenjing Ma, Zackary Rousseau, Sladjana Slavkovic, Chuanbin Shen, George M. M. Yousef, Heyu Ni
Summary: This study found that Doxorubicin induced platelet activation and increased macrophage phagocytosis of platelets, leading to accelerated platelet clearance. Salvianolic acid C (SAC), derived from Danshen root, was found to inhibit Doxorubicin-induced platelet activation more effectively than current anti-platelet drugs. Doxorubicin also enhanced platelet-cancer cell interaction, which was alleviated by SAC.