Microfluidic culture models to study the hydrodynamics of tumor progression and therapeutic response

Three-Dimensional Microfluidic Collagen Hydrogels for Investigating Flow-Mediated Tumor-Endothelial Signaling and Vascular Organization

(2013) Cara F. Buchanan et al.   TISSUE ENGINEERING PART C-METHODS

Microtechnology for Mimicking In Vivo Tissue Environment

(2012) Jong Hwan Sung et al.   ANNALS OF BIOMEDICAL ENGINEERING

Fluid flows and forces in development: functions, features and biophysical principles

(2012) J. B. Freund et al.   DEVELOPMENT

Anastomosis of endothelial sprouts forms new vessels in a tissue analogue of angiogenesis

(2012) Jonathan W. Song et al.   Integrative Biology

Mechanism of a flow-gated angiogenesis switch: early signaling events at cell–matrix and cell–cell junctions

(2012) Vernella Vickerman et al.   Integrative Biology

Microfluidic single-cell real-time PCR for comparative analysis of gene expression patterns

(2012) Veronica Sanchez-Freire et al.   Nature Protocols

Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels

(2012) Yoojin Shin et al.   Nature Protocols

Ensemble Analysis of Angiogenic Growth in Three-Dimensional Microfluidic Cell Cultures

(2012) Waleed A. Farahat et al.   PLoS One

Implanted adipose progenitor cells as physicochemical regulators of breast cancer

(2012) E. M. Chandler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sprouting Angiogenesis under a Chemical Gradient Regulated by Interactions with an Endothelial Monolayer in a Microfluidic Platform

(2011) Gi Seok Jeong et al.   ANALYTICAL CHEMISTRY

Microfluidics for Mammalian Cell Chemotaxis

(2011) Beum Jun Kim et al.   ANNALS OF BIOMEDICAL ENGINEERING

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber

(2011) Ulrike Haessler et al.   Integrative Biology

In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients

(2011) Yoojin Shin et al.   LAB ON A CHIP

Assessing the Permeability of Engineered Capillary Networks in a 3D Culture

(2011) Stephanie J. Grainger et al.   PLoS One

Interstitial flow influences direction of tumor cell migration through competing mechanisms

(2011) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluid forces control endothelial sprouting

(2011) J. W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alginate based 3D hydrogels as an in vitro co-culture model platform for the toxicity screening of new chemical entities

(2011) Shih-Feng Lan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Wall Shear Stress Measurements in an Arterial Flow Bioreactor

(2011) Elizabeth E. Voigt et al.   Cardiovascular Engineering and Technology

Microfluidic Platforms for Studies of Angiogenesis, Cell Migration, and Cell–Cell Interactions

(2010) Seok Chung et al.   ANNALS OF BIOMEDICAL ENGINEERING

Effect of mechanical factors on the function of engineered human blood microvessels in microfluidic collagen gels

(2010) Gavrielle M. Price et al.   BIOMATERIALS

Dense type I collagen matrices that support cellular remodeling and microfabrication for studies of tumor angiogenesis and vasculogenesis in vitro

(2010) Valerie L. Cross et al.   BIOMATERIALS

The role of cyclic AMP in normalizing the function of engineered human blood microvessels in microfluidic collagen gels

(2010) Keith H.K. Wong et al.   BIOMATERIALS

Alginate-based microfluidic system for tumor spheroid formation and anticancer agent screening

(2010) Michael C. W. Chen et al.   BIOMEDICAL MICRODEVICES

Tumors on chips: oncology meets microfluidics

(2010) Donald Wlodkowic et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

3D microchannel co-culture: method and biological validation

(2010) Maret Bauer et al.   Integrative Biology

Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects

(2010) Kyung Eun Sung et al.   Integrative Biology

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models

(2010) DAI FUKUMURA et al.   MICROCIRCULATION

Assay of glioma cell responses to an anticancer drug in a cell-based microfluidic device

(2010) Wenming Liu et al.   Microfluidics and Nanofluidics

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

(2010) Robert W. Tilghman et al.   PLoS One

Microfluidic Culture Models of Tumor Angiogenesis

(2010) Abraham D. Stroock et al.   TISSUE ENGINEERING PART A

Bio-microfluidics: Biomaterials and Biomimetic Designs

(2009) Peter Domachuk et al.   ADVANCED MATERIALS

Microscale Control of Stiffness in a Cell-Adhesive Substrate Using Microfluidics-Based Lithography

(2009) Yuk Kee Cheung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A microfluidic chip for permeability assays of endothelial monolayer

(2009) Jianbo Shao et al.   BIOMEDICAL MICRODEVICES

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

A microfluidic device for characterizing the invasion of cancer cells in 3-D matrix

(2009) Tingjiao Liu et al.   ELECTROPHORESIS

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Macro- and microscale fluid flow systems for endothelial cell biology

(2009) Edmond W. K. Young et al.   LAB ON A CHIP

In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts

(2009) Jean Y Perentes et al.   NATURE METHODS

Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells

(2009) Jonathan W. Song et al.   PLoS One

Biomechanical Regulation of Endothelium-dependent Events Critical for Adaptive Remodeling

(2008) Peter J. Mack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging

(2008) Vernella Vickerman et al.   LAB ON A CHIP

Cell migration into scaffolds under co-culture conditions in a microfluidic platform

(2008) Seok Chung et al.   LAB ON A CHIP

A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics

(2008) Colin L. Walsh et al.   LAB ON A CHIP

Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab

(2008) M Pickl et al.   ONCOGENE

A perfusable 3D cell-matrix tissue culture chamber for in situ evaluation of nanoparticle vehicle penetration and transport

(2007) Chee Ping Ng et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microfluidics for drug discovery and development: From target selection to product lifecycle management

(2007) L KANG   DRUG DISCOVERY TODAY

Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorin

(2007) Mazin Magzoub et al.   FASEB JOURNAL