Article
Medicine, General & Internal
M. A. Wu, T. Fossali, L. Pandolfi, L. Carsana, D. Ottolina, V. Frangipane, R. Rech, A. Tosoni, G. Lopez, A. Agarossi, C. Cogliati, F. Meloni, B. Marchini, M. Nebuloni, E. Catena, R. Colombo
Summary: The study found that hypoalbuminaemia could serve as a marker of severity in patients with COVID-19, indicating epithelial-endothelial damage. Additionally, there are indications that pulmonary capillary leak syndrome plays a crucial role in the pathogenesis of COVID-19.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Water Resources
Saeed Telvari, Mohammad Sayyafzadeh, Javad Siavashi, Mohammad Sharifi
Summary: Multiphase fluid flow in porous media is important in environmental and industrial fields. Pore-scale modeling can estimate macroscopic properties, but it is complex and time-consuming. A framework is proposed involving sub-sample extraction, computation of permeability and pressure, training a CNN, and validation. The CNN is trained with grayscale images, reducing computational time significantly.
ADVANCES IN WATER RESOURCES
(2023)
Review
Multidisciplinary Sciences
Nicholas Rogozinski, Apuleyo Yanez, Rahulkumar Bhoi, Moo-Yeal Lee, Huaxiao Yang
Summary: 3D cardiac engineered constructs not only advance cardiac regenerative medicine but also enable more accurate modeling of healthy and diseased cardiac tissues. This review highlights the relationship between different cell types and advanced fabrication methods, shedding light on various pathologies and providing therapeutic potential for damaged myocardium. The future direction is focused on creating specialized and personalized constructs with region-specific microtopography and function.
Article
Biology
Aref Saberi, Albert P. Aldenkamp, Nicholas A. Kurniawan, Carlijn V. C. Bouten
Summary: This research developed a method to engineer cerebral tissues with intact neuronal networks, mimicking neuropathological signatures such as epileptiform discharges. By promoting cell reaggregation and using a multi-chambered tissue culture chip, the study successfully simulated brain network disorders.
COMMUNICATIONS BIOLOGY
(2022)
Article
Peripheral Vascular Disease
Jing Bai, Mehrdad Khajavi, Lufei Sui, Haojie Fu, Subrahmanian Tarakkad Krishnaji, Amy E. Birsner, Lauren Bazinet, Roger D. Kamm, Robert J. D'Amato
Summary: This study developed a novel microfluidic platform for studying angiogenesis, comparing angiogenic properties between different mouse strains, and mechanistically demonstrating that the Padi2 gene promotes angiogenesis through Notch1/Dll4 signaling. Analysis of the interactions between primary endothelial cells and pericytes in a 3D microfluidic environment helps elucidate the angiogenic response.
Article
Construction & Building Technology
Wang Fei, Yang Yutong, Yin Shiping
Summary: Research on the performance of PVA-ECC as a building envelope material is limited, this study investigated the thermal and moisture properties of PVA-ECC by experimental methods. The results show that PVA-ECC has good dry density, porosity, water absorption, vapor permeability, and thermal conductivity, making it suitable for building envelope material.
JOURNAL OF BUILDING ENGINEERING
(2021)
Article
Engineering, Biomedical
Suyeong Seo, Chi-Hoon Choi, Kyung Sik Yi, Seung U. Kim, Kangwon Lee, Nakwon Choi, Hong Jun Lee, Sang-Hoon Cha, Hong Nam Kim
Summary: The neurovascular unit (NVU) is composed of various types of brain cells that play important roles in maintaining the molecular transport barrier and brain tissue homeostasis. Dysfunction of the NVU has been associated with several disorders of the central nervous system, highlighting the importance of developing in vitro models for studying and understanding NVU-related mechanisms.
Article
Chemistry, Multidisciplinary
Mao Mao, Pengyu Chen, Jiankang He, Guangyu Zhu, Xiao Li, Dichen Li
Summary: Leaf venation provides a promising template for engineering capillary-like vasculature in vitro. This study proposes a modeling strategy to accurately simulate the flow conditions in leaf-inspired capillary networks (LICNs) and demonstrates their excellent fluid transport capability. The optimal perfusion parameter for the formation of endothelialized capillary networks is determined, and the correlation between cancer cell adhesion and flow-induced shear stress is investigated.
Article
Geosciences, Multidisciplinary
Zhaolong Ge, Yudong Hou, Zhe Zhou, Zepeng Wang, Maolin Ye, Shan Huang, Hui Zhang
Summary: A method of reconstructing 3D pore-fracture networks using nuclear magnetic resonance and CT was proposed, and the relationship between the structural characteristics of the networks and permeability was studied. The permeability evolution under high-pressure CO2 was investigated using COMSOL software, and a reliable model was established for predicting permeability.
NATURAL RESOURCES RESEARCH
(2023)
Article
Construction & Building Technology
Sofia Pessoa, Manuel Jesus, Ana S. Guimaraes, Sandra S. Lucas, Nuno Simoes
Summary: 3D printing has great potential in the construction sector for automation, sustainability, and quality control. However, there is limited research on the thermal performance, comfort, and energy efficiency of 3D printed construction solutions. This study experimentally analyzes a cement-based mortar developed for 3D printing, obtaining a range of physical, hygric, and thermal properties. The results show that the 3D printed cement-based mortar has comparable hygrothermal performance to traditional cast concrete but requires additional insulation materials for thermal performance.
CASE STUDIES IN CONSTRUCTION MATERIALS
(2023)
Article
Construction & Building Technology
Sadegh Ghourchian, Marko Butler, Markus Krueger, Viktor Mechtcherine
Summary: 3D concrete printing is a promising technology in construction automation, but special attention should be paid to controlling the development of capillary pressure to prevent plastic shrinkage cracking. A poromechanical model has been developed in this investigation to predict the development of capillary pressure in 3D-printed elements, showing that substituting cement with silica fume accelerates the development of capillary pressure.
CEMENT AND CONCRETE RESEARCH
(2021)
Article
Engineering, Electrical & Electronic
Duong Duy Duong, Jisung Kwak, Hyun Seok Song, Nae Yoon Lee
Summary: This study demonstrated the fabrication of a microfluidic device to mimic the human blood-brain barrier in vitro using cellulose fiber membrane, PDMS layers, and seeded cells. Evaluation of cell viability, TEER, and permeability confirmed the feasibility and efficacy of the model, showing potential for in vitro drug screening applications.
MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS
(2021)
Article
Thermodynamics
Rong Fu, Xuegong Hu, Hanjia Zhang, Yuying Yan, Wenbin Zhou, Jihui Wang
Summary: This study investigates the influence of Fe3O4-water nanofluids on capillary performance in microgrooves wick, aiming to enhance the thermal performance of two-phase heat transfer devices. Experimental results show that nanofluids significantly improve capillary performance by enhancing wetting and flow in the wick. Depending on temperature and particle concentration, the Capillary Performance Parameter increases by 8-75% compared to the base liquid. The mechanism behind the improvement in wetting and flow is attributed to particle migrations and aggregation within the groove.
APPLIED THERMAL ENGINEERING
(2021)
Article
Chemistry, Physical
H. N. Vo, M. F. Pucci, S. Drapier, P. J. Liotier
Summary: This study estimated and explored the capillary pressure of two fabrics in Liquid Composite Moulding processes, and discovered new results such as linear trends, thresholds, and extremums. These findings are valuable for predicting void formation and estimating the importance of capillary effects in the process.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Cell Biology
Fatemeh Navaee, Niloofar Khornian, David Longet, Sarah Heub, Stephanie Boder-Pasche, Gilles Weder, Alexander Kleger, Philippe Renaud, Thomas Braschler
Summary: Alignment of cardiomyocytes in myocardium tissue is important for the functions of the myocardium. This paper proposes a simple method to align cells in a 3D in vitro heart model using microfabricated PDMS grooves. The functionality of the model was evaluated by comparing beating rates between aligned and non-aligned structures. This model has potential applications in drug screening, tissue engineering, and heart-on-chip studies.
Article
Engineering, Biomedical
Benjamin A. Juliar, Jeffrey A. Beamish, Megan E. Busch, David S. Cleveland, Likitha Nimmagadda, Andrew J. Putnam
Article
Engineering, Biomedical
Xiaofang Lu, Hai Jin, Carole Quesada, Easton C. Farrell, Leidan Huang, Mitra Aliabouzar, Oliver D. Kripfgans, J. Brian Fowlkes, Renny T. Franceschi, Andrew J. Putnam, Mario L. Fabiilli
ACTA BIOMATERIALIA
(2020)
Article
Multidisciplinary Sciences
Nicole E. Friend, Ana Y. Rioja, Yen P. Kong, Jeffrey A. Beamish, Xiaowei Hong, Julia C. Habif, Jonathan R. Bezenah, Cheri X. Deng, Jan P. Stegemann, Andrew J. Putnam
SCIENTIFIC REPORTS
(2020)
Article
Engineering, Biomedical
Eric C. Hobson, Weiping Li, Benjamin A. Juliar, Andrew J. Putnam, Jan P. Stegemann, Cheri X. Deng
Summary: Resonant Acoustic Rheometry (RAR) is a new, non-contact technique for characterizing mechanical properties of soft and viscoelastic biomaterials. RAR uses surface wave analysis to extract material properties, providing consistent quantitative data and dynamic performance tracking. It circumvents limitations of conventional rheology methods and is a valuable noninvasive tool for quantifying viscoelastic mechanical properties.
Article
Engineering, Biomedical
Leidan Huang, Carole Quesada, Mitra Aliabouzar, J. Brian Fowlkes, Renny T. Franceschi, Zheng Liu, Andrew J. Putnam, Mario L. Fabiilli
Summary: Vascularization following tissue implantation is crucial for viability, and the ability to spatially control this process using acoustically responsive scaffolds has been demonstrated in this study. The study found that spatially-defined patterns of acoustic droplet vaporization can elicit spatially-defined patterns of angiogenesis.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Easton Farrell, Mitra Aliabouzar, Carole Quesada, Brendon M. Baker, Renny T. Franceschi, Andrew J. Putnam, Mario L. Fabiilli
Summary: A novel composite hydrogel, called an acoustically-responsive scaffold (ARS), has been developed for non-invasive, spatiotemporally controlled modulation of mechanical and morphological properties using focused ultrasound. The study demonstrates that ARS can effectively control the differentiation of fibroblasts into myofibroblasts and induce matrix compaction and stiffening.
ACTA BIOMATERIALIA
(2022)
Article
Cell Biology
Douhong Zou, Marina Vigen, Andrew J. Putnam, Chen Cao, Susan A. Tarle, Tyler Guinn, Darnell Kaigler
Summary: Mesenchymal stem cells (MSCs) have variable regenerative properties depending on their tissue source, with MSCs from alveolar bone tissue showing significantly higher bone regenerative capacity compared to those from bone marrow. Transcriptomic analysis revealed differentially expressed genes between MSC populations from different osseous tissue sites, providing insights on MSC differences based on tissue origin.
CELL AND TISSUE RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Hai Jin, Carole Quesada, Mitra Aliabouzar, Oliver D. Kripfgans, Renny T. Franceschi, Jianhua Liu, Andrew J. Putnam, Mario L. Fabiilli
Summary: A hydrogel-based delivery system for growth factors with modulated release by focused ultrasound was successfully utilized to prevent critical limb ischemia in a preclinical model. In vivo, the combination of acoustically-responsive scaffolds (ARS) and FUS showed superior efficacy compared to other groups, with more perfusion and less necrosis, significantly increased angiogenesis, and reduced fibrosis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Nicole E. Friend, Atticus J. McCoy, Jan P. Stegemann, Andrew J. Putnam
Summary: The formation of functional capillary blood vessels in engineered tissues remains a challenge. In this study, researchers investigated the effects of matrix properties on vessel network formation using PEG hydrogels. By varying the crosslinking ratio and incorporating cleavage sites, they found that reducing crosslinking or increasing degradability promoted vascularization and cell-mediated stiffening. These findings highlight the importance of cell-mediated remodeling for rapid vessel formation.
Article
Engineering, Biomedical
Mitra Aliabouzar, Carole Quesada, Ze Qi Chan, J. Brian Fowlkes, Renny T. Franceschi, Andrew J. Putnam, Mario L. Fabiilli
Summary: Researchers have developed a smart hydrogel that can generate micropores in a controlled manner using focused ultrasound, allowing for potential biomedical applications.
ACTA BIOMATERIALIA
(2023)
Article
Endocrinology & Metabolism
Alexander Ky, Atticus J. Mccoy, Carmen G. Flesher, Nicole E. Friend, Jie Li, Kore Akinleye, Christopher Patsalis, Carey N. Lumeng, Andrew J. Putnam, Robert W. O'Rourke
Summary: The alterations of extracellular matrix contribute to dysfunction of adipose tissue in metabolic disease. In this study, we found that intermediate density matrix promotes more adipocyte generation, reduces fibrosis, and enhances lipid and aerobic metabolism.
Meeting Abstract
Cell & Tissue Engineering
E. A. Margolis, L. S. Choi, N. E. Friend, A. J. Putnam
TISSUE ENGINEERING PART A
(2022)
Article
Biochemical Research Methods
Emily A. Margolis, David S. Cleveland, Yen P. Kong, Jeffrey A. Beamish, William Y. Wang, Brendon M. Baker, Andrew J. Putnam
Summary: This study compared three different types of stromal cells and their influence on supporting microvasculature formation, with lung fibroblasts showing superior support for endothelial cell morphogenesis and functional perfusion of capillary beds. The heightened traction stress produced by lung fibroblasts may be a mechanism for their enhanced role in endothelial morphogenesis compared to other stromal cell types. These findings offer insights for selecting cells for vascular cell-based therapies and regulating tissue-specific vasculature.
Proceedings Paper
Engineering, Electrical & Electronic
Hai Jin, Carole Quesada, Leidan Huang, Mitra Aliabouzar, Aniket Jivani, Oliver D. Kripfgans, J. Brian Fowlkes, Renny T. Franceschi, Jianhua Liu, Andrew J. Putnam, Mario L. Fabiilli
PROCEEDINGS OF THE 2020 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)
(2020)
Article
Chemistry, Physical
Mitra Aliabouzar, Christopher D. Davidson, William Y. Wang, Oliver D. Kripfgans, Renny T. Franceschi, Andrew J. Putnam, J. Brian Fowlkes, Brendon M. Baker, Mario L. Fabiilli