A physiologically based pharmacokinetic (PBPK) approach to evaluate pharmacokinetics in patients with cancer

The Role of Physiologically Based Pharmacokinetic Modeling in Regulatory Review

(2012) S-M Huang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Influence of H2-receptor antagonists and proton pump inhibitors on dasatinib pharmacokinetics in Japanese leukemia patients

(2011) Naoto Takahashi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Pharmacokinetics of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Locally Advanced or Metastatic Solid Tumors: the Role of Alpha-1-Acid Glycoprotein Binding

(2011) R. A. Graham et al.   CLINICAL CANCER RESEARCH

Cancer screening in older adults: What to do when we don't know

(2011) Shabbir M.H. Alibhai et al.   Journal of Geriatric Oncology

The Effects of Multiple Doses of Rolofylline on the Single-Dose Pharmacokinetics of Midazolam in Healthy Subjects

(2010) Mark Stroh et al.   AMERICAN JOURNAL OF THERAPEUTICS

NCT01110291: induction of CYP3A activity and lowered exposure to docetaxel in patients with primary breast cancer

(2010) Johanna Hilli et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Marginal increase of sunitinib exposure by grapefruit juice

(2010) Nielka P. van Erp et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance

(2010) Trevor N. Johnson et al.   CLINICAL PHARMACOKINETICS

The Effects of Hypoalbuminaemia on Optimizing Antibacterial Dosing in Critically Ill Patients

(2010) Marta Ulldemolins et al.   CLINICAL PHARMACOKINETICS

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

(2010) P Zhao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

An open-label, randomized, single-center, two-period, phase I, crossover study of the effect of zibotentan (ZD4054) on the pharmacokinetics of midazolam in healthy male volunteers

(2010) Helen K. Tomkinson et al.   CLINICAL THERAPEUTICS

Effect of glycyrrhizin on the activity of CYP3A enzyme in humans

(2010) Jiang-Hua Tu et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Population pharmacokinetic model of PI-88, a heparanase inhibitor

(2009) Susan F. Hudachek et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A Population Pharmacokinetic Meta-analysis of Sunitinib Malate (SU11248) and Its Primary Metabolite (SU12662) in Healthy Volunteers and Oncology Patients

(2009) B. E. Houk et al.   CLINICAL CANCER RESEARCH

A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

(2009) Masoud Jamei et al.   Drug Metabolism and Pharmacokinetics

The Simcyp®Population-based ADME Simulator

(2009) Masoud Jamei et al.   Expert Opinion on Drug Metabolism & Toxicology

Lack of effect of subject posture on intravenous midazolam clearance: implications for hepatic cytochrome P450 3A phenotyping

(2008) Joseph D. Ma et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Covariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling

(2008) Z. E. Barter et al.   DRUG METABOLISM AND DISPOSITION