Article
Chemistry, Multidisciplinary
Jintao Lu, Dan Zhang, Xiaomeng Zhang, Rina Sa, Xiaofang Wang, Huanzhang Wu, Zhijian Lin, Bing Zhang
Summary: This study investigated the herb-drug interactions of citrus herbs, identifying potential active ingredients and targets through network analysis and molecular docking. The findings shed light on the mechanisms of interaction and provided predictions for clinical applications.
Article
Chemistry, Multidisciplinary
Jintao Lu, Dan Zhang, Xiaomeng Zhang, Rina Sa, Xiaofang Wang, Huanzhang Wu, Zhijian Lin, Bing Zhang
Summary: This study investigated the interactions between citrus herbs and drugs, identifying shared potential active compounds and verifying the predictions through molecular docking and cell experiments. Further clinical and experimental evidence is needed to support these findings.
Article
Biochemical Research Methods
Disha Thakkar, Amit Kumar Sahu, Rajeshwari Rathod, Pinaki Sengupta, Abhijeet S. Kate
Summary: The study found that the combined administration of grapefruit juice and pomegranate juice increased the systemic exposure of Brexpiprazole and affected its pharmacokinetic parameters, while tomato juice had no significant effect.
BIOMEDICAL CHROMATOGRAPHY
(2021)
Article
Multidisciplinary Sciences
Sarvesh Sabarathinam, Satish Kumar Rajappan Chandra, Vijayakumar Thangavel Mahalingam
Summary: The study found that the Maha yogaraja guggulu is a commonly used herbomineral polyherbal formulation that affects CYP3A4-mediated metabolism. Experimental results suggest that this formulation and its guggulsterone isomers may have drug interaction potential when used in combination with CYP3A4 substrates.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yan Zhang, Yiping Yu, Hong Li, Wenge Huang, Ping Wang
Summary: This study investigated the effects of Citri Reticulatae Pericarpium (CRP) and grapefruit juice (GFJ) on the pharmacokinetics of omeprazole, finding that CRP may increase the bioavailability of omeprazole by inhibiting hepatic cytochrome P450 enzymes, while GFJ may decrease the clearance of omeprazole. Both CRP and GFJ contain bioactive compounds that could affect drug metabolism. These findings have implications for the safe and effective clinical use of omeprazole and the development of new functional products.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Kenza Mansoor, Razan Bardees, Bayan Alkhawaja, Eyad Mallah, Luay AbuQatouseh, Mathias Schmidt, Khalid Matalka
Summary: Pomegranate juice contains a variety of polyphenols that have numerous health benefits. However, it can interact with certain drugs, affecting their metabolism and efficacy. Current research focuses on the impact of pomegranate juice on CYP3A4 and CYP2C9 metabolized drugs.
Article
Biochemistry & Molecular Biology
Mayur R. Ladole, Pravin B. Pokale, Vrushali R. Varude, Prasad G. Belokar, Aniruddha B. Pandit
Summary: In this study, enzymes pectinase and naringinase were co-immobilized on chitosan coated magnetic nanoparticles, resulting in a biocatalyst with improved thermal stability and recyclability. The newly synthesized biocatalyst showed promising potential for applications in juice clarification and debittering processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Maria Stella Cosio, Alessandro Pellicano, Claudio Gardana, Carlos Alberto Fuenmayor
Summary: This study investigates the effect of electrospun nylon-6 nanofibrous membranes (NFMs) on the concentration of bitter compounds and antioxidants in grapefruit juices during dead-end filtration processes. The results show that NFMs selectively retain low molecular weight antioxidants at early filtration stages and remove bitter glycosylated phenolics at a variable ratio depending on membrane thickness. Filtration of fresh grapefruit juice using NFMs reduces flavanones associated with immediate bitterness and completely removes limonin, the compound responsible for persistent bitterness. NFMs have potential in selectively reducing bitter terpenoids and glycosylated flavonoids from grape juice in the production of beverages.
Article
Pharmacology & Pharmacy
Kevin O'Gallagher, Sarah Borg Cardona, Callum Hill, Ali Al-Saedi, Fawzia Shahed, Christopher N. Floyd, Karen McNeill, Charlotte E. Mills, Andrew J. Webb
Summary: This study found that grapefruit juice enhanced the effect of beetroot juice on lowering systolic blood pressure and pulse pressure, despite decreasing plasma nitrite levels. This suggests more complex mechanisms at play and potential for maximizing the clinical benefits of dietary nitrate in targeting isolated systolic hypertension.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Food Science & Technology
Yaiza Gonzalez-Temino, Maria O. Ruiz, Natividad Ortega, Sonia Ramos-Gomez, Maria D. Busto
Summary: An enzymatic membrane reactor (EMR) was developed for the immobilization of naringinase, achieving a high conversion rate of naringin in grapefruit juice and maintaining its antioxidant properties. The immobilized enzyme showed consistent catalytic activity over multiple reaction runs and storage periods. The research represents a technological advancement in biocatalytic membranes for juice debittering.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2021)
Article
Pharmacology & Pharmacy
Laura Maria Fuhr, Fatima Zahra Marok, Uwe Fuhr, Dominik Selzer, Thorsten Lehr
Summary: Grapefruit is a potent inhibitor of CYP3A4, which can affect the metabolism of CYP3A4 victim drugs for up to 24 hours after consumption. This study developed a physiologically-based pharmacokinetic model to simulate and predict the effect of grapefruit juice on the plasma concentration-time profiles of various CYP3A4 victim drugs.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Radina Tokin, Johan Orskov Ipsen, Mahesha M. Poojary, Poul Erik Jensen, Lisbeth Olsson, Katja Salomon Johansen
Summary: Fermented persimmon juice, Kakishibu, is traditionally used for wood and paper protection, partly due to its inhibition of microbial cellulose degrading enzymes. The inhibitory effect of Kakishibu on lytic polysaccharide monooxygenases (LPMOs) and cellulose hydrolases was studied. Both polyethylene glycol and tannase can alleviate the inhibitory effect of Kakishibu and tannic acid on LPMOs, suggesting an unspecific tannin-protein interaction mechanism.
Article
Chemistry, Analytical
Ashraf M. Mahmoud, Saad A. Alkahtani, Yahya S. Alqahtani, Rasha M. K. Mohamed, Mohamed M. El-Wekil, Al-Montaser Bellah H. Ali
Summary: This study presents a novel method for accurately determining naringin in grapefruit juice using N-doped carbon dots synthesized from eggplant peel waste. The method relies on fluorescence quenching and selective extraction using ion exchange resin. The method showed excellent linearity, low detection limit, and demonstrated its feasibility in real-world application.
MICROCHEMICAL JOURNAL
(2023)
Article
Oncology
Zhangbiao Long, Min Ruan, Wei Wu, Qingshu Zeng, Qingsheng Li, Zhengqi Huang
Summary: Venetoclax combined with hypomethylating agents is the standard treatment for elderly AML patients who are not suitable for intensive therapy. However, the high cost of venetoclax often leads to financial difficulties for patients. This study explored a regime using low-dose venetoclax, azacitidine, and grapefruit juice in an unfit AML patient with TP53 mutation, and achieved successful remission.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Reem S. S. Alazragi, Hanadi M. M. Baeissa
Summary: This study aimed to examine the anti-arthritic properties of grapefruit juice and found that it can reduce inflammation levels, slow down cartilage degradation, and improve joint function.
Letter
Pharmacology & Pharmacy
Mirjam de With, Jonathan Knikman, Jan H. M. Schellens, Hans Gelderblom, Annemieke Cats, Henk-Jan Guchelaar, Ron H. J. Mathijssen, Jesse J. Swen, Didier Meulendijks
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Oncology
Astrid Lipplaa, Debora Meijer, Michiel A. J. van de Sande, Hans Gelderblom, Judith V. M. G. Bovee, Hailiang Mei, Karoly Szuhai
Summary: This article describes a newly identified gene fusion in diffuse TSGCT, which potentially plays a vital role in the pathogenesis of the disease.
GENES CHROMOSOMES & CANCER
(2023)
Article
Pharmacology & Pharmacy
Maryam Lyousoufi, Iris Lafeber, Dinemarie Kweekel, Brenda C. M. de Winter, Jesse J. J. Swen, Paul P. H. Le Brun, Erica C. M. Bijleveld-Olierook, Teun van Gelder, Henk-Jan Guchelaar, Dirk Jan A. R. Moes, Kirsten J. M. Schimmel
Summary: Personalized medicine lacks flexible drug formulations, especially for pediatric patients. This study investigates the feasibility of developing a 3D-printed tablet formulation at the point-of-care that complies with quality requirements for clinical practice, including bioequivalence.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Oncology
Emanuela Palmerini, John H. Healey, Nicholas M. Bernthal, Sebastian Bauer, Hendrik Schreuder, Andreas Leithner, Javier Martin-Broto, Francois Gouin, Julio Lopez-Bastida, Hans Gelderblom, Eric L. Staals, Florence Mercier, Petra Laeis, Xin Ye, Michiel van de Sande
Summary: This article describes the impact of Tenosynovial giant cell tumor (D-TGCT) on patient-reported outcomes (PROs) based on the Tenosynovial giant cell tumor Observational Platform Project (TOPP) registry. The study found that patients without active treatment strategy had lower pain levels and better quality of life at 1-year and 2-year follow-ups. On the other hand, patients receiving systemic treatment had higher pain levels when they changed treatment strategies. These findings highlight the significant impact of treatment strategies on patient quality of life.
Article
Oncology
Rieneke T. Lugtenberg, Stefanie de Groot, Danny Houtsma, Vincent O. Dezentje, Annelie J. E. Vulink, Maarten J. Fischer, Johanneke E. A. Portielje, Jacobus J. M. van der Hoeven, Hans Gelderblom, Hanno Pijl, Judith R. Kroep
Summary: Docetaxel, an anti-cancer agent, can cause hypersensitivity reactions and fluid retention. High-dose corticosteroids, such as dexamethasone, have been used to reduce these adverse effects, but there is little evidence to support this practice and high doses of corticosteroids can have undesirable effects. This study aimed to evaluate the impact of reducing the dose of dexamethasone on the incidence of hypersensitivity reactions and fluid retention in patients with breast or prostate cancer.
Letter
Pharmacology & Pharmacy
Henk-Jan Guchelaar, Jesse Swen
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Oncology
William D. Tap, Maitreyi G. Sharma, Marc Vallee, Bryan D. Smith, Matthew L. Sherman, Rodrigo Ruiz-Soto, Michiel van de Sande, R. Lor Randall, Nicholas M. Bernthal, Hans Gelderblom
Summary: TGCT is a rare neoplasm caused by upregulation of the CSF1 gene. Vimseltinib, an oral tyrosine kinase inhibitor, is being tested in the Phase III MOTION trial for its efficacy and safety in TGCT patients who are not suitable for surgery. Participants will receive vimseltinib or placebo in Part 1, followed by open-label vimseltinib treatment in Part 2.
Article
Medicine, General & Internal
Adrian Sacher, Patricia LoRusso, Manish R. Patel, Wilson H. Miller, Elena Garralda, Martin D. Forster, Armando Santoro, Alejandro Falcon, Tae Won Kim, Luis Paz-Ares, Samantha Bowyer, Maria de Miguel, Sae-Won Han, Matthew G. Krebs, Jong-Seok Lee, Michael L. Cheng, Kathryn Arbour, Erminia Massarelli, Yoonha Choi, Zhen Shi, Sandhya Mandlekar, Mark T. Lin, Stephanie Royer-Joo, Julie Chang, Neekesh V. Dharia, Jennifer L. Schutzman, Jayesh Desai
Summary: Divarasib, a KRAS G12C inhibitor, has shown promising therapeutic effects with minimal adverse events in patients with tumors harboring the KRAS G12C mutation.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Astrid Lipplaa, Willem H. Schreuder, Sarina E. C. Pichardo, Hans Gelderblom
Summary: This study aimed to determine the efficacy of denosumab in patients with giant cell rich tumors of bone (GCRTB) that have recurred or require morbid surgery. Due to low patient accrual, the study was prematurely stopped and the results did not support the use of denosumab for this indication.
Editorial Material
Pharmacology & Pharmacy
Sofia L. J. Peeters, Maarten J. Deenen, Anna M. J. Thijs, Emma C. Hulshof, Ron H. J. Mathijssen, Hans Gelderblom, Henk-Jan Guchelaar, Jesse J. Swen
Article
Orthopedics
Gijsbert M. M. Kalisvaart, Thomas Van Den Berghe, Willem Grootjans, Maryse Lejoly, Wouter C. J. Huysse, Judith V. M. G. Bovee, David Creytens, Hans Gelderblom, Frank M. M. Speetjens, Lore Lapeire, Michiel A. J. van de Sande, Gwen Sys, Lioe-Fee de Geus-Oei, Koenraad L. L. Verstraete, Johan L. L. Bloem
Summary: This study aimed to identify the best DCE-MRI features that can predict histological response to neoadjuvant chemotherapy in osteosarcoma patients. The results showed that using the whole slab segmentation method and setting a threshold of relative wash-in rate <2.3 provided the most accurate prediction. The findings were externally validated in a separate test cohort.
SKELETAL RADIOLOGY
(2023)
Review
Oncology
J. -y. Blay, M. von Mehren, R. L. Jones, J. Martin-Broto, S. Stacchiotti, S. Bauer, H. Gelderblom, D. Orbach, N. Hindi, A. Dei Tos, M. Nathenson
Summary: Synovial sarcoma is a rare and aggressive disease, accounting for 5%-10% of all soft tissue sarcomas. Diagnosis is often challenging, but referral to a specialist center is crucial for optimal outcomes. Treatment strategies for localized disease include surgery, radiotherapy, and chemotherapy, while advanced disease has a poor prognosis and requires novel management strategies such as targeted agents and immunotherapies.
Article
Pharmacology & Pharmacy
Jonathan E. Knikman, Marta Lopez-Yurda, Didier Meulendijks, Maarten J. Deenen, Jan H. M. Schellens, Jos Beijnen, Annemieke Cats, Henk-Jan Guchelaar
Summary: DPYD-guided dosing has improved the safety of fluoropyrimidine-based chemotherapy. However, severe toxicity still occurs in patients without DPYD variant alleles. Therefore, researchers developed a predictive model based on patient and treatment factors to estimate the risk of severe toxicity. Internal validation showed good predictive ability of the model.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)