Article
Biotechnology & Applied Microbiology
Lorena R. Lizarraga-Valderrama, Giulia Ronchi, Rinat Nigmatullin, Federica Fregnan, Pooja Basnett, Alexandra Paxinou, Stefano Geuna, Ipsita Roy
Summary: The study demonstrated that PHA-NGCs are highly promising in promoting peripheral nerve regeneration, showing comparable outcomes to autografts in functional evaluation and nerve morphology.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Kinga Molnar, Bernat Nogradi, Rebeka Kristof, Adam Meszaros, Krisztian Pajer, Laszlo Siklos, Antal Nogradi, Imola Wilhelm, Istvan A. Krizbai
Summary: In peripheral nerve injury, the activation of inflammasomes in motor neurons of the spinal cord triggers an inflammatory reaction and activates microglia. Inhibition of neuronal inflammasome activation not only reduces microglia response significantly but also has a beneficial effect on nerve regeneration.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell Biology
Bruno Henrique de Melo Lima, Andre Luis Bombeiro, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues De Oliveira
Summary: The expression of MHC-I and other related molecules following peripheral nerve injury is associated with the recovery of neurons, glial cells, sensorimotor function, gait, and nociceptive threshold in mice. Different strains of mice exhibit varying recovery capacities.
Article
Biochemistry & Molecular Biology
Mashanipalya G. Jagadeeshaprasad, Prem Kumar Govindappa, Amanda M. Nelson, Mark D. Noble, John C. Elfar
Summary: The discovery of the effectiveness of 4-aminopyridine (4-AP) in enhancing skin wound healing is of great importance due to the high frequency of skin injuries. The treatment with 4-AP has shown several benefits, including faster wound closure, restoration of normal skin structure, increased hair follicle neogenesis, and improved neuronal regeneration. This approach also increases the levels of important promoters of wound healing, such as transforming growth factor-beta, substance P, and nerve growth factor. In vitro studies have shown that 4-AP promotes nerve growth factor production and enhances the proliferation and migration of human keratinocytes. Overall, this research presents a promising new approach to enhance skin wound healing and tissue regeneration.
Article
Engineering, Biomedical
Shengran Wang, Changlai Zhu, Bin Zhang, Junxia Hu, Jinghui Xu, Chengbin Xue, Shuangxi Bao, Xiaokun Gu, Fei Ding, Yumin Yang, Xiaosong Gu, Yun Gu
Summary: A favorable microenvironment is crucial for nerve regeneration. This study investigates the components and spatial organization of extracellular matrix (ECM) secreted by different cells and finds that ECM derived from bone marrow mesenchymal cells (BMSCs) is more similar to acellular nerves. ECM-modified nerve grafts (ECM-NGs) co-cultivated with BMSCs exhibit the most promising nerve repair properties and create a superior microenvironment for nerve regeneration, indicating a potential alternative for clinical repair of peripheral nerve defects.
Review
Biotechnology & Applied Microbiology
Rebecca Powell, Despoina Eleftheriadou, Simon Kellaway, James B. Phillips
Summary: This review discusses the physical processes by which natural biomaterials mimic the function of the extracellular matrix and regulate cellular behavior, as well as highlights representative cases of controllable cell microenvironments developed through the combination of cell biology and tissue engineering principles.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Farzaneh Jabbari, Valiollah Babaeipour, Samaneh Bakhtiari
Summary: Nerve injuries and neurodegenerative disorders pose serious medical challenges, but new electroactive biomaterials like bacterial cellulose (BC) show promise in promoting nerve regeneration when combined with conductive structures. Electrical stimulation has positive effects on cellular activity, including adhesion, proliferation, migration, and differentiation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Peripheral Vascular Disease
Kenichi Katsurada, Kazuomi Kario
Summary: Inappropriate sympathetic activation is closely linked to hypertension. Renal denervation is an effective therapy for hypertension with significant and lasting antihypertensive effects. However, there are still issues to be addressed, such as the precise mechanisms and long-term effects of renal denervation. Comprehensive understanding of renal nerves and the antihypertensive mechanisms of renal denervation will improve its clinical application.
HYPERTENSION RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Junjie Shen, Jiayan Wang, Xuanzhe Liu, Yi Sun, Anlin Yin, Yimin Chai, Kuihua Zhang, Chunyang Wang, Xianyou Zheng
Summary: The study developed an in situ prevascularization strategy using 3D porous nerve guidance conduits for angiogenesis-mediated neural regeneration, showing significant neuroregeneration effects in vivo similar to traditional autografts.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Melissa L. D. Rayner, Adam G. E. Day, Kulraj S. Bhangra, John Sinden, James B. Phillips
Summary: This study provides evidence supporting the effectiveness of using engineered neural tissue (EngNT) as a replacement for nerve autografts, with functional regeneration assessed through histological and electrophysiological outcome measures demonstrating equivalent performance.
ACTA BIOMATERIALIA
(2021)
Review
Biotechnology & Applied Microbiology
Shuai Chen, Carmen J. Gil, Liqun Ning, Linqi Jin, Lilanni Perez, Gabriella Kabboul, Martin L. Tomov, Vahid Serpooshan
Summary: This article discusses the significance of Adhesive Tissue Engineering Scaffolds (ATESs), reviewing their key characteristics and requirements, exploring mechanisms of action for securing the scaffold onto tissue, and presenting strategies for assessing adhesive properties. Current applications and future prospects of advanced ATES systems in regenerative medicine therapies are highlighted, along with key challenges in various fields of tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yasaman Mozhdehbakhsh Mofrad, Amir Shamloo
Summary: Injectable conductive hydrogels are a promising treatment option for nervous system injuries, but research in this area is limited. This study developed a chitosan/beta-glycerophosphate/salt hydrogel with added conductive aligned nanofibers to improve its biochemical and biophysical properties, inspired by natural nerve tissue. The results showed that the degradation rate of the hydrogels is proportional to axon regrowth. Additionally, the mechanical and electrical properties of these hydrogels, as well as the interconnective structure of the scaffolds, were found to support cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Josefa Alarcon Apablaza, Maria Florencia Lezcano, Karina Godoy Sanchez, Gonzalo H. Oporto, Fernando Jose Dias
Summary: This scoping review summarizes the adequate quantitative/morphometric parameters of polymeric nerve guide conduits (NGCs) that provide a supportive environment for nerve regeneration. Optimal morphometric characteristics, such as wall thickness, fiber size, pore size, and porosity, are identified to enhance nerve regeneration and reduce the need for experimental studies.
Article
Clinical Neurology
Jayme A. Bertelli, Isadora Carvalho Nunes Rosa, Marcos F. Ghizoni
Summary: This study aimed to investigate whether axons could regenerate in a retrograde fashion within sensory pathways and then extend into motor pathways, leading to muscle reinnervation. The results showed that although there were electrophysiological and histological findings of nerve regeneration after nerve transfers, no behavioral recovery was observed.
NEUROLOGICAL RESEARCH
(2023)
Review
Neurosciences
Wenqian Zhao, Hui Tu, Jianxiao Chen, Jing Wang, Haoting Liu, Fengshou Zhang, Jing Li
Summary: Repairing injuries to the nervous system has always been a prominent topic in clinical research. With the emergence of tissue engineering, hydrogel materials have been identified as a promising technology for repairing nervous system injuries. By controlling their composition and structure, hydrogels can be functionalized and almost fully matched with nerve tissue, making them suitable for repairing injuries to both the central and peripheral nervous systems.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Haishan Jiao, Jian Yao, Yuening Song, Ying Chen, Dongyin Li, Xiaomei Liu, Xue Chen, Weiwei Lin, Yi Li, Xiaodong Wang
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2015)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.