Article
Biotechnology & Applied Microbiology
Lorena R. Lizarraga-Valderrama, Giulia Ronchi, Rinat Nigmatullin, Federica Fregnan, Pooja Basnett, Alexandra Paxinou, Stefano Geuna, Ipsita Roy
Summary: The study demonstrated that PHA-NGCs are highly promising in promoting peripheral nerve regeneration, showing comparable outcomes to autografts in functional evaluation and nerve morphology.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Faranak Mankavi, Rana Ibrahim, Hongjun Wang
Summary: This article summarizes the recent advances in nerve guidance conduits (NGCs) for peripheral nerve regeneration and repair, including biomaterial innovations, structural design, advanced fabrication technologies, and cellular responses to biomimetic cues.
Article
Chemistry, Multidisciplinary
Yangnan Hu, Zhuoyue Chen, Hongyang Wang, Jiahui Guo, Jiaying Cai, Xiaoyan Chen, Hao Wei, Jieyu Qi, Qiuju Wang, Huisheng Liu, Yuanjin Zhao, Renjie Chai
Summary: Inspired by the structures of peripheral nerves, researchers have developed a conductive topological scaffold for nerve repair using modified butterfly wings. The scaffold showed increased neurite length and guided cellular orientation, and successfully repaired nerve defects in rats.
Review
Chemistry, Multidisciplinary
Kai Liu, Lesan Yan, Ruotao Li, Zhiming Song, Jianxun Ding, Bin Liu, Xuesi Chen
Summary: Nerve autograft is currently the preferred treatment for peripheral nerve defects but has limitations. Emerging nerve guide conduits (NGCs), especially those made through 3D printing, offer effective platforms for repairing peripheral nerve defects.
Article
Engineering, Biomedical
Qingqing Lu, Feng Zhang, Weinan Cheng, Xiang Gao, Zhaozhao Ding, Xiaoyi Zhang, Qiang Lu, David L. Kaplan
Summary: The study utilized modular assembly for fabricating nerve conduits with multifunctional guidance cues, which promoted cell proliferation and growth factor secretion, and demonstrated improved nerve regeneration in both cell and animal experiments for rat sciatic nerve defects.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Teng Wan, Yi-Lin Wang, Feng-Shi Zhang, Xiao-Meng Zhang, Yi-Chong Zhang, Hao-Ran Jiang, Meng Zhang, Pei-Xun Zhang
Summary: This review discusses the importance of porous structures in peripheral nerve guidance conduits (NGCs) and their impact on physical properties and cellular behavior during peripheral nerve regeneration. It provides an overview of the features and classification of porous structures in NGCs, as well as common methods for constructing them. The review also emphasizes the significance of ideal porous structures in the regeneration of peripheral nerve tissue engineering materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Biomaterials
Riley A. Suhar, Laura M. Marquardt, Shang Song, Hana Buabbas, Vanessa M. Doulames, Patrik K. Johansson, Katarina C. Klett, Ruby E. Dewi, Annika M. K. Enejder, Giles W. Plant, Paul M. George, Sarah C. Heilshorn
Summary: Synthetic nerve guidance conduits (NGCs) provide an alternative for treating peripheral nerve injury, utilizing both naturally derived and synthesized materials. Protein engineered recombinant ELP hydrogels as intraluminal fillers enhance tissue bridge formation and functional control, supporting peripheral nerve regeneration. Further study of these materials as off-the-shelf alternatives for nerve regeneration is warranted.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Review
Biotechnology & Applied Microbiology
Ane Escobar, Rui Luis Reis, Joaquim Miguel Oliveira
Summary: Peripheral nerve injuries are a common cause of disabilities, and treatment with long nerve gap autografts is currently considered the best method. However, due to limited availability and potential issues at the donor site, research is focusing on developing regenerative strategies using artificial nerve guidance conduits (NGCs). These NGCs can be optimized through various methods to enhance nerve regeneration, and recent advancements in using different types of nanoparticles to introduce growth factors to NGCs are discussed in depth.
Review
Polymer Science
Sangjoon Lee, Madhumita Patel, Rajkumar Patel
Summary: This review presents the challenges associated with autologous nerve grafting and the potential of artificial nerve guidance conduits (NGCs) as an alternative treatment method for peripheral nerve injuries (PNIs). The tubular NGCs provide guidance and protection for nerve growth and elongation. Novel designs of electrospun NGCs offer promising prospects for functional recovery.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Shang Wu, Wen Shen, Xuemei Ge, Fen Ao, Yan Zheng, Yigang Wang, Xiaoni Jia, Yueyang Mao, Yali Luo
Summary: Peripheral nerve injury is a common complication, and the traditional autologous nerve graft approach is limited. Nerve guidance conduits are widely used as an alternative, but they currently cannot meet the needs of large gap nerve injuries. Functional nerve conduits that incorporate electrical or magnetic stimulation and Schwann cells show promise for bridging large gap nerve injuries. Additionally, functional nerve conduits provide a new method for constructing drug and growth factor delivery systems in vivo.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Cell Biology
Jesus Chato-Astrain, Olga Roda, David Sanchez-Porras, Esther Miralles, Miguel Alaminos, Fernando Campos, Oscar Dario Garcia-Garcia, Victor Carriel
Summary: Growth-associated protein 43 plays a key role in neurite outgrowth through cytoskeleton remodeling. In this study, it was found that growth-associated protein 43 is expressed not only in the regenerating nerve tissue but also in the spinal cord after peripheral nerve transection. These findings suggest that growth-associated protein 43 could be used as a marker to monitor changes in the central nervous system after peripheral nerve injury.
NEURAL REGENERATION RESEARCH
(2023)
Article
Engineering, Biomedical
Hongkui Wang, Ping Zhang, Panjian Lu, Xiaodong Cai, Gang Wang, Xi Xu, Ying Liu, Tianyi Huang, Meiyuan Li, Tianmei Qian, Hui Zhu, Chengbin Xue
Summary: In this study, a subcutaneously pre-vascularized tissue-engineered nerve graft (TENG) was developed using a vascular endothelial growth factor-induced host vascular network, chitosan nerve conduit, and inserted silk fibroin fibers. The functionality of regenerated blood vessels was confirmed through various imaging techniques and 3D reconstruction. Pre-vascularized TENG facilitated rapid vascular inosculation and enhanced the migration of vascular endothelial cells (VECs) and Schwann cells (SCs), promoting axonal regrowth and remyelination. The transplantation of pre-vascularized TENG resulted in the recovery of electrophysiological function and prevention of muscle atrophy.
MATERIALS TODAY BIO
(2023)
Article
Cell & Tissue Engineering
Diego Noe Rodriguez-Sanchez, Giovana Boff Araujo Pinto, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira, Ana Livia Carvalho Bovolato, Marcio de Carvalho, Jorge Vicente Lopes da Silva, Janaina de Andrea Dernowsek, Marjorie Golim, Benedito Barraviera, Rui Seabra Ferreira, Elenice Deffune, Mathues Bertanha, Rogerio Martins Amorim
Summary: The study demonstrated that the combination of 3D-printed PLC-NGCs with AdMSCs derived from adipose tissue exerted neuroregenerative effects on rats with sciatic nerve injury, improving motor function and nerve conduction.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, Research & Experimental
Chushan Zheng, Zehong Yang, Shihao Chen, Fang Zhang, Zilong Rao, Cailing Zhao, Daping Quan, Ying Bai, Jun Shen
Summary: NGCs composed of longitudinally aligned electrospun nanofibers and 0.25% pDNM gel show promising outcomes in directing axonal extension, promoting nerve fiber myelination, and facilitating functional recovery. Furthermore, T2-mapping and DTI metrics are found to be useful non-invasive monitoring techniques for PNI treatment.
Article
Engineering, Biomedical
Yao Liu, Xiaonong Zhang, Chunsheng Xiao, Bin Liu
Summary: Peripheral nerve injury (PNI) is a complex disease that commonly affects young adults and has limited treatment options and poor clinical outcomes. Tissue-engineered hydrogels have shown promising results in promoting neural tissue regeneration and recovery of impaired neural function. This review discusses recent advances and various therapeutic strategies of hydrogels in peripheral nerve repair, as well as the prospects and challenges in their application for PNI treatment.
MATERIALS TODAY BIO
(2023)
Article
Surgery
Hongyi Zhu, Bingbo Bao, Xianyou Zheng
PLASTIC AND RECONSTRUCTIVE SURGERY
(2018)
Article
Clinical Neurology
Bingbo Bao, Kai Fu, Xianyou Zheng, Haifeng Wei, Pengbo Luo, Hongyi Zhu, Xiaozhong Zhu, Xingwei Li, Tao Gao
JOURNAL OF SPINAL CORD MEDICINE
(2020)
Article
Medicine, Research & Experimental
Tao Gao, Hongyi Zhu, Changqing Zhang, Yimin Chai, Cheng Guo, Xiaozhong Zhu, Bingbo Bao, Xingwei Li, Junqing Lin, Xianyou Zheng
Article
Cell & Tissue Engineering
T. Gao, J. Lin, C. Zhang, H. Zhu, X. Zheng
BONE & JOINT RESEARCH
(2020)
Article
Orthopedics
Hongyi Zhu, Bingbo Bao, Haifeng Wei, Tao Gao, Yimin Chai, Changqing Zhang, Xianyou Zheng
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2020)
Article
Chemistry, Multidisciplinary
Yun Qian, Yuan Cheng, Jialin Song, Yang Xu, Wei-En Yuan, Cunyi Fan, Xianyou Zheng
Article
Orthopedics
Hongyi Zhu, Junqing Lin, Haifeng Wei, Bingbo Bao, Tao Gao, Xianyou Zheng
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2020)
Article
Orthopedics
Xiao-zhong Zhu, Teng-li Huang, Hong-yi Zhu, Bing-bo Bao, Tao Gao, Xing-wei Li, Jun-qing Lin, Xian-You Zheng
Summary: A retrospective cohort study involving 334 comminuted patellar fractures stabilized with tension band constructs compared the outcomes of using modified Kirschner-wire tension band, cannulated-screw tension band, or ring-pin tension band. The study found that the CSTB group had the highest fixation failure rate, while RPTB had the advantage of lower rates of symptomatic hardware removal compared to MKTB. Skin breakdown and infection rates did not significantly differ among the groups.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Cell & Tissue Engineering
J. Lin, T. Gao, H. Wei, H. Zhu, X. Zheng
Summary: In wound irrigation, EDTA at concentrations below 10 mM is safe for use. The optimal concentration of EDTA-NS varies depending on the type of wound after experimental inoculation of three types of wound models.
BONE & JOINT RESEARCH
(2021)
Article
Neurosciences
Bingbo Bao, Lei Duan, Haifeng Wei, Pengbo Luo, Hongyi Zhu, Tao Gao, Xiaoer Wei, Jing Li, Yuehua Li, Yimin Chai, Changqing Zhang, Xianyou Zheng
Summary: The study found significant changes in ALFF and DC in the sensorimotor cortex and cognitive-related brain regions after upper-limb amputation, indicating dysfunction in sensory and motor function, as well as areas responsible for sensorimotor integration and motor planning. Cortical reorganization post-amputation was shown to be more complicated than previously thought, affecting widespread regions.
Article
Cell & Tissue Engineering
Junjie Shen, Yi Sun, Xuanzhe Liu, Yu Zhu, Bingbo Bao, Tao Gao, Yimin Chai, Jia Xu, Xianyou Zheng
Summary: EGFL6 was found to stimulate angiogenesis and osteogenic differentiation through the Wnt/beta-catenin signaling pathway in vitro, and promoted CD31(hi)EMCN(hi) type H-positive capillary formation in a rat tibia distraction osteogenesis model. It enhanced the osteogenic differentiation potential of BMSCs and accelerated bone regeneration by stimulating angiogenesis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Neurosciences
Bingbo Bao, Haifeng Wei, Pengbo Luo, Hongyi Zhu, Wencheng Hu, Yi Sun, Junjie Shen, Tianhao Zhu, Junqing Lin, Tengli Huang, Jing Li, Zhibin Wang, Yuehua Li, Xianyou Zheng
Summary: The right parietal lobe is crucial in body image and cognition, and is closely associated with body image disorders and altered body awareness in upper-limb amputees. Upper-limb amputation may result in reorganization in local brain areas and more widespread functional connectivity changes throughout the entire brain.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Engineering, Environmental
Junqing Lin, Wencheng Hu, Tao Gao, Bingbo Bao, Xingwei Li, Tengli Huang, Yi Sun, Junjie Shen, Hannan Xu, Kaiyuan Zhu, Hongyi Zhu, Yunlong Yang, Xianyou Zheng
Summary: The study evaluated the potential of epsilon-PLL as a cost-effective, biosafe, and effective CMC for drug delivery to cartilage. The results showed strong distribution and retention of epsilon-PLL in cartilage, with no negative impact on chondrocytes or local tissue, indicating its effectiveness and safety for DMOAD delivery.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Surgery
Xingwei Li, Xiaozhong Zhu, Hongyi Zhu, Changqing Zhang, Yimin Chai, Xianyou Zheng
JBJS ESSENTIAL SURGICAL TECHNIQUES
(2019)