Dissecting the role of His domain protein tyrosine phosphatase/PTPN23 and ESCRTs in sorting activated epidermal growth factor receptor to the multivesicular body

Proteomics reveals novel protein associations with early endosomes in an epidermal growth factor–dependent manner

(2018) Julie A. Gosney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ESCRT-dependent cargo sorting at multivesicular endosomes

(2018) E.B. Frankel et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase

(2017) Siwei Zhang et al.   GENES & DEVELOPMENT

Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP

(2017) Deepankar Gahloth et al.   STRUCTURE

Cellular Functions and Molecular Mechanisms of the ESCRT Membrane-Scission Machinery

(2017) Liliane Christ et al.   TRENDS IN BIOCHEMICAL SCIENCES

The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function

(2017) Deepankar Gahloth et al.   Scientific Reports

Phosphorylation-Dependent Activation of the ESCRT Function of ALIX in Cytokinetic Abscission and Retroviral Budding

(2016) Sheng Sun et al.   DEVELOPMENTAL CELL

ESCRT-III and Vps4: a dynamic multipurpose tool for membrane budding and scission

(2016) Manuel Alonso Y Adell et al.   FEBS Journal

Reverse-topology membrane scission by the ESCRT proteins

(2016) Johannes Schöneberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Study of the HD-PTP Bro1 Domain in a Complex with the Core Region of STAM2, a Subunit of ESCRT-0

(2016) Juhyeon Lee et al.   PLoS One

Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1

(2016) Deepankar Gahloth et al.   STRUCTURE

Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer

(2016) Sanaz Manteghi et al.   Cell Reports

A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I

(2015) M. D. J. Parkinson et al.   BIOCHEMICAL JOURNAL

Unravelling the pivotal role of Alix in MVB sorting and silencing of the activated EGFR

(2015) Sheng Sun et al.   BIOCHEMICAL JOURNAL

Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation

(2015) Nicolas Chiaruttini et al.   CELL

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation

(2015) Haisha Ma et al.   CELLULAR SIGNALLING

ESCRTs are everywhere

(2015) J. H. Hurley   EMBO JOURNAL

Negative membrane curvature catalyzes nucleation of endosomal sorting complex required for transport (ESCRT)-III assembly

(2015) Il-Hyung Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway

(2015) Alejandra Tomas et al.   Nature Communications

Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration

(2015) Dmitri Kharitidi et al.   Cell Reports

ALG-2 activates the MVB sorting function of ALIX through relieving its intramolecular interaction

(2015) Sheng Sun et al.   Cell Discovery

VPS37 Isoforms Differentially Modulate the Ternary Complex Formation of ALIX, ALG-2, and ESCRT-I

(2013) Mayumi OKUMURA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Recruitment of UBPY and ESCRT Exchange Drive HD-PTP-Dependent Sorting of EGFR to the MVB

(2013) Nazim Ali et al.   CURRENT BIOLOGY

Tumor-suppressive Function of Protein-tyrosine Phosphatase Non-receptor Type 23 in Testicular Germ Cell Tumors Is Lost upon Overexpression of miR142–3p microRNA

(2013) Kiyoko Tanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex

(2013) L. Wunderley et al.   JOURNAL OF CELL SCIENCE

EGF receptor trafficking: consequences for signaling and cancer

(2013) Alejandra Tomas et al.   TRENDS IN CELL BIOLOGY

ALIX and the multivesicular endosome: ALIX in Wonderland

(2013) Christin Bissig et al.   TRENDS IN CELL BIOLOGY

Molecular Mechanisms of the Membrane Sculpting ESCRT Pathway

(2013) W. M. Henne et al.   Cold Spring Harbor Perspectives in Biology

Endocytosis and Cancer

(2013) I. Mellman et al.   Cold Spring Harbor Perspectives in Biology

Solution Structure of the ESCRT-I and -II Supercomplex: Implications for Membrane Budding and Scission

(2012) Evzen Boura et al.   STRUCTURE

The UBAP1 Subunit of ESCRT-I Interacts with Ubiquitin via a SOUBA Domain

(2012) Monica Agromayor et al.   STRUCTURE

Multivesicular Body Morphogenesis

(2011) Phyllis I. Hanson et al.   Annual Review of Cell and Developmental Biology

UBAP1 Is a Component of an Endosome-Specific ESCRT-I Complex that Is Essential for MVB Sorting

(2011) Flavia Stefani et al.   CURRENT BIOLOGY

Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'

(2011) G. Lin et al.   GENES & DEVELOPMENT

Association of the Endosomal Sorting Complex ESCRT-II with the Vps20 Subunit of ESCRT-III Generates a Curvature-sensitive Complex Capable of Nucleating ESCRT-III Filaments

(2011) Ian Fyfe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Retroviral Budding Factor ALIX

(2011) Q. Zhai et al.   JOURNAL OF VIROLOGY

Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy

(2011) E. Boura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications

(2010) Takumi Tsunematsu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Decoding the intrinsic mechanism that prohibits ALIX interaction with ESCRT and viral proteins

(2010) Xi Zhou et al.   BIOCHEMICAL JOURNAL

microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network

(2010) Liming Zhang et al.   CARCINOGENESIS

VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo

(2010) Xuefeng Ren et al.   EMBO JOURNAL

ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation

(2010) David Teis et al.   EMBO JOURNAL

Oncogenic mutant forms of EGFR: Lessons in signal transduction and targets for cancer therapy

(2010) Gur Pines et al.   FEBS LETTERS

CBL Is Frequently Altered in Lung Cancers: Its Relationship to Mutations in MET and EGFR Tyrosine Kinases

(2010) Yi-Hung Carol Tan et al.   PLoS One

Histidine Domain-Protein Tyrosine Phosphatase Interacts with Grb2 and GrpL

(2010) Carmen-Alexandra Tanase   PLoS One

Functional Reconstitution of ESCRT-III Assembly and Disassembly

(2009) Suraj Saksena et al.   CELL

Signaling Transduction Network Mediated by Tumor Suppressor/Susceptibility Genes in NPC

(2009) Minghua Wu et al.   CURRENT GENOMICS

Hybrid Structural Model of the Complete Human ESCRT-0 Complex

(2009) Xuefeng Ren et al.   STRUCTURE

A Crescent-Shaped ALIX Dimer Targets ESCRT-III CHMP4 Filaments

(2009) Ricardo Pires et al.   STRUCTURE

Ordered Assembly of the ESCRT-III Complex on Endosomes Is Required to Sequester Cargo during MVB Formation

(2008) David Teis et al.   DEVELOPMENTAL CELL

The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis

(2008) A. Doyotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Midbody Targeting of the ESCRT Machinery by a Noncanonical Coiled Coil in CEP55

(2008) H. H. Lee et al.   SCIENCE