Article
Oncology
Robin Guo, Michael Offin, A. Rose Brannon, Jason Chang, Andrew Chow, Lukas Delasos, Jeffrey Girshman, Olivia Wilkins, Caroline G. McCarthy, Alex Makhnin, Christina Falcon, Kerry Scott, Yuan Tian, Fabiola Cecchi, Todd Hembrough, Deepu Alex, Ronglai Shen, Ryma Benayed, Bob T. Li, Charles M. Rudin, Mark G. Kris, Maria E. Arcila, Natasha Rekhtman, Paul Paik, Ahmet Zehir, Alexander Drilon
Summary: In MET exon 14-altered lung cancers treated with a MET TKI, the genomic mechanisms of primary resistance remain unknown, while MET expression is correlated with treatment benefit.
CLINICAL CANCER RESEARCH
(2021)
Review
Endocrinology & Metabolism
Rong Tang, Wallace Y. Langdon, Jian Zhang
Summary: Receptor tyrosine kinases (RTKs) are transmembrane receptors involved in various cellular processes. The negative regulation of RTKs by the Cbl family proteins has attracted interest for potential therapeutic applications in diseases including cancer.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jian-Hua Luo, Silvia Liu, Junyan Tao, Bao-Guo Ren, Katherine Luo, Zhang-Hui Chen, Michael Nalesnik, Kathleen Cieply, Tianzhou Ma, Shi-Yuan Cheng, Qi Chen, George K. Michalopoulos, Joel B. Nelson, Rohit Bhargava, Jun Zhang, Deqin Ma, David Jarrard, Arjun Pennathur, James D. Luketich, Donald B. DeFranco, Satdarshan Paul Monga, George Tseng, Yan-Ping Yu
Summary: The fusion gene Pten-NOLC1, derived from Pten gene, is a driver for human cancers as it promotes cancer proliferation, growth, invasion, and metastasis. Its presence in primary cancer samples and cancer cell lines from different organs suggests its significance in oncogenesis.
Article
Chemistry, Multidisciplinary
Xinyuan Xi, Fan Lei, Keliang Gao, Jingjing Li, Rihe Liu, Adam R. Karpf, Tatiana K. Bronich
Summary: Combining chemotherapeutic drugs in a single nanocarrier offers advantages in cancer treatment, including reducing toxicity, improving drug properties, and enhancing therapeutic effects. In this study, we developed functional multimodal polypeptide-based polymeric nanogels (NGs) to encapsulate a combination of drugs. These NGs exhibited selective cytotoxicity towards EGFR overexpressing ovarian cancer cells and showed preferential associations with EGFR (+) tumor cells. Furthermore, ligand-installed NGs carrying the drug combination significantly improved the treatment response of ovarian cancer xenografts compared to individual drug-loaded NGs. This work highlights the potential of our carrier system for efficient delivery of drug combinations to treat EGFR overexpressing cancers.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Analytical
Xiaoxu Li, Bo Sun, Jianhua Zhu, Moting Qian, Yun Chen
Summary: Protein dimerization plays a significant role in cellular signaling and understanding its quantitative analysis is important for clinical cancer management.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Michael D. Paul, Kalina Hristova
Summary: This study proposes a provocative hypothesis that active, ligand-bound RTK dimers from unrelated subfamilies can associate into heterooligomers with novel signaling properties, supported by quantitative FRET study. Direct interactions between EGFR and VEGFR2 are observed in the absence of ligand and in the presence of both ligands, suggesting a novel mechanism for signal diversification.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Biology
Minseong Kim, Carmen Reinhard, Christof Niehrs
Summary: MET is identified as the kinase responsible for phosphorylating the 4Y motif in ZNRF3, leading to reduced degradation of Wnt receptors and enhanced Wnt/beta-catenin signaling. HGF-MET signaling phosphorylates ZNRF3, while PTPRK dephosphorylates it, regulating ZNRF3 internalization and functioning as a potential therapeutic target for Wnt signaling modulation.
Article
Medicine, Research & Experimental
Dantong Sun, Weizheng Wu, Li Wang, Jialin Qu, Qiman Han, Huiyun Wang, Shanai Song, Ning Liu, Yongjie Wang, Helei Hou
Summary: MET fusions are rare in lung cancer patients, with an occurrence rate of 0.2% to 0.3%. In this study, intragenic MET fusions were found in 52.6% of the included patients. Crizotinib was effective in treating MET fusions, including a new type called EML4-MET fusion. This study sheds light on the rarity and therapeutic potential of MET fusions in lung cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Yu-Ra Choi, Eun Hye Kang, Sunshin Kim, Seog-Yun Park, Ji-Youn Han, Youngjoo Lee
Summary: This study evaluated the efficacy of single MET inhibition in EGFR-mutant and MET-amplified lung cancer and found that it produced a short-lived response. Further research on novel combination therapy schedules is needed to achieve long-lasting efficacy with less toxicity.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Beiyuan Hu, Tiantian Zou, Wei Qin, Xiaotian Shen, Yinghan Su, Jianhua Li, Yang Chen, Ze Zhang, Haoting Sun, Yan Zheng, Chao-Qun Wang, Zhengxin Wang, Tian-En Li, Shun Wang, Le Zhu, Xufeng Wang, Yan Fu, Xudong Ren, Qiongzhu Dong, Lun-Xiu Qin
Summary: Lenvatinib, a first-line treatment for hepatocellular carcinoma (HCC), has limited clinical benefits. This study reveals that HCC cells develop resistance to Lenvatinib by activating the EGFR-STAT3-ABCB1 pathway. Combined treatment with erlotinib, an EGFR inhibitor, may overcome acquired resistance and improve the clinical benefit of Lenvatinib.
Article
Oncology
Sara Garcia-Alonso, Ines Romero-Perez, Lucia Gandullo-Sanchez, Luis Chinchilla, Alberto Ocana, Juan Carlos Montero, Atanasio Pandiella
Summary: The activation of the EGFR-TGF alpha axis plays a significant role in the pathophysiology of kidney cancer. The presence of membrane-anchored TGF alpha in tumors could be therapeutically exploited, potentially through targeted antibody drug conjugates. Differences in the molecular forms of TGF alpha expressed by tumors and normal tissues were also identified in this study.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Takuma Matsubara, William N. Addison, Shoichiro Kokabu, Lynn Neff, William Horne, Francesca Gori, Roland Baron
Summary: Deletion of c-Src results in osteoclast dysfunction and osteopetrosis, which cannot be compensated for by other SFKs. The unique function of c-Src in osteoclasts is partially derived from its interaction with c-Cbl, crucial for cytoskeleton organization and efficient bone resorption.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Kexin Zhang, Zhicheng Huang, Yadong Wang, Jianchao Xue, Naixin Liang, Zewen Wei
Summary: The current first-line treatment choice for lung cancer is either chemotherapy or targeted medicine based on the presence of EGFR mutations. Next-generation sequencing is accurate in detecting EGFR mutations, but it is expensive and may cause delays. To address this, a new method for rapidly determining EGFR mutations using DNA nanocalipers is developed in this study.
Article
Chemistry, Medicinal
Omkulthom M. Alkamaly, Najla Altwaijry, Rehab Sabour, Marwa F. Harras
Summary: Novel derivatives of the pyrazoline scaffold showed significant and broad-spectrum anticancer activities with lower cytotoxicity against normal cells. Compounds 5b and 7c were identified as potent dual EGFR and VEGFR2 inhibitors, with strong apoptotic effects on cancer cells. The compounds also demonstrated potential as apoptosis inducers through molecular docking analyses.
ARCHIV DER PHARMAZIE
(2021)
Review
Biochemistry & Molecular Biology
Barbara Hayes, Peter van der Geer
Summary: STS-1 and STS-2 are a small family of proteins involved in regulating protein-tyrosine kinase signal transduction. They have UBA, esterase, SH3, and PGM domains. The UBA and SH3 domains are used to modify protein-protein interactions, while the PGM domain catalyzes protein-tyrosine dephosphorylation. This manuscript discusses the proteins that interact with STS-1 or STS-2 and the experiments used to uncover these interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
I-Ying Kuo, Danping Liu, Wu-Wei Lai, Yi-Ching Wang, Y. Peng Loh
Summary: This study evaluates the efficacy of CPE/CPE-Delta N mRNA as a biomarker for predicting recurrence in lung adenocarcinoma patients. The results show that CPE/CPE-Delta N copy number is associated with recurrence and death, and it performs better in predicting recurrence in stage I and II patients.
Article
Medicine, Research & Experimental
Pei-Shan Yang, Min-Hua Yu, Ya-Chin Hou, Chih-Peng Chang, Shao-Chieh Lin, I-Ying Kuo, Pei-Chia Su, Hung-Chi Cheng, Wu-Chou Su, Yan-Shen Shan, Yi-Ching Wang
Summary: This study provides the first evidence that Rab37 mediates CHI3L1 secretion in immune cells and highlights the dual properties of CHI3L1 nAbs that can target both cancer cells and the tumor microenvironment.
Article
Oncology
Hsueh-Chien Chiang, Meng-Ying Lin, Forn-Chia Lin, Nai-Jung Chiang, Yi-Ching Wang, Wu-Wei Lai, Wei-Lun Chang, Bor-Shyang Sheu
Summary: This study aimed to compare the sensitivity of serum prealbumin, transferrin, and albumin in detecting malnutrition and predicting survival in esophageal cancer patients. The results showed that prealbumin and transferrin outperformed albumin in identifying malnutrition and poor prognosis.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Oncology
Yung-Ching Chen, Ming-Jer Young, Hui-Ping Chang, Chia-Yu Liu, Chia-Chi Lee, Yau-Lin Tseng, Yi-Ching Wang, Wen-Chang Chang, Jan-Jong Hung
Summary: This study reveals that estrogen negatively regulates DNMT1 and p53 expression in female lung cancer, which not only affects tumor cells but also modulates the tumor microenvironment, leading to a poor prognosis.
Review
Medicine, Research & Experimental
Chih-Hsiung Hsieh, Yi-Ching Wang
Summary: The protein gelsolin plays a significant role in controlling cytoskeletal remodeling, cell morphology, differentiation, movement, and apoptosis. Its expression has been found to be decreased in various pathological conditions and it has emerged as a potential diagnostic biomarker for early disease detection. Gelsolin can function as either an oncoprotein or a tumor suppressor depending on the type of carcinoma. This review discusses the roles of gelsolin in inflammation and wound healing, cancers, and tumor microenvironment, as well as future prospects for related studies and clinical application.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Oncology
Yi-Zih Kuo, Ya-Rong Kang, Wei-Lun Chang, Lydia Chin-Ling Sim, Tzu-Chin Hsieh, Chu-Han Chang, Yi-Ching Wang, Ching-Jung Tsai, Li-Chun Huang, Sen-Tien Tsai, Li-Wha Wu
Summary: YAP1 acts as a tumor suppressor in esophageal cancer, while TAZ plays a pro-tumor role. YAP1 negatively regulates the expression of TAZ through transcriptional and translational control.
Article
Cell Biology
Shan-Ying Wu, Hung-Tsung Wu, Yi-Ching Wang, Chih-Jen Chang, Yan-Shen Shan, Shang-Rung Wu, Yen-Chi Chiu, Chia-Lang Hsu, Hsueh-Fen Juan, Kai-Ying Lan, Chi-Wen Chu, Ying-Ray Lee, Sheng-Hui Lan, Hsiao-Sheng Liu
Summary: This study reveals that secretory autophagy promotes RAB37-mediated insulin secretion to maintain the homeostasis of insulin and glucose.
Correction
Oncology
Yi-Zih Kuo, Ya-Rong Kang, Wei-Lun Chang, Lydia Chin Ling Sim, Tzu-Chin Hsieh, Chu-Han Chang, Yi-Ching Wang, Ching-Jung Tsai, Li-Chun Huang, Sen-Tien Tsai, Li-Wha Wu
Article
Biochemistry & Molecular Biology
Wei-Lun Chang, Chih-Hsiung Hsieh, I-Ying Kuo, Chien-Hsun Lin, Yu-Lin Huang, Yi-Ching Wang
Summary: A novel therapeutic agent, Nutlin-3, has been proposed to enhance the treatment efficacy of chemoradiation-resistant ESCC by regulating the expression of transcription factor proteins p53 and RB and downregulating the level of DNA methyltransferase. It has the potential for clinical application.
MOLECULAR CARCINOGENESIS
(2022)
Editorial Material
Cell Biology
Shan-Ying Wu, Yi-Ching Wang, Roberto Zuchini, Kai-Ying Lan, Hsiao-Sheng Liu, Sheng-Hui Lan
Summary: RAB37 GTPase regulates cargo exocytosis by cycling between GDP-bound and GTP-bound forms. It also simultaneously regulates autophagy activation and TIMP1 secretion in lung cancer cells under starvation conditions. Secretory autophagy participates in TIMP1 secretion in a RAB37- and Sec22b-dependent manner. Autophagy induction facilitates TIMP1 secretion and suppresses the motility and metastasis of lung cancer cells in a RAB37-dependent manner in a lung-to-lung mouse model.
Article
Cell Biology
Shaifali Singh, Nai Yang Yeat, Ya-Ting Wang, Shu-Yu Lin, I-Ying Kuo, Kuen-Phon Wu, Won-Jing Wang, Wen-Ching Wang, Wu-Chou Su, Yi-Ching Wang, Ruey-Hwa Chen
Summary: WDR4/PTPN23 axis plays a central role in the trafficking of EGFR and c-MET in non-small cell lung cancer (NSCLC). WDR4-mediated PTPN23 ubiquitination inhibits lysosome trafficking and degradation, sustaining EGFR and c-MET signaling and promoting NSCLC proliferation, migration, and metastasis. Clinical studies show that low expression of PTPN23 is associated with high expression of WDR4 and poor prognosis in lung cancer. Targeting WDR4-mediated PTPN23 ubiquitination may be a potential therapeutic strategy for EGFR TKI-resistant NSCLC.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Shan-Ying Wu, Jia-Wen Chen, Hsi-Yu Liu, Yi-Ching Wang, Yeh-Shiu Chu, Chi-Ying Huang, Kai-Ying Lan, Hsiao-Sheng Liu, Sheng-Hui Lan
Summary: This study is the first to report that autophagy promotes the secretion and metastasis of TIMP1 in a Rab37-dependent manner in lung cancer cells and a lung-to-lung mouse model.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Cell Biology
Chih-Hsiung Hsieh, Wen-Hui Kuan, Wei-Lun Chang, I-Ying Kuo, Hsun Liu, Dar-Bin Shieh, Hsuan Liu, Bertrand Tan, Yi-Ching Wang
Summary: This study identifies a novel SOX17(low)/NRF2(high) signature in ESCC patients with poor prognosis, recognizes SOX17 as a transcriptional repressor of NRF2, and provides a promising strategy targeting SOX17/NRF2 axis to overcome resistance.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Cell Biology
I. -Ying Kuo, Chih-Hsiung Hsieh, Wan-Ting Kuo, Chih-Peng Chang, Yi-Ching Wang
Summary: Cells in the tumor microenvironment require a class of checkpoints to regulate various secretion and transport processes. Recent studies have shown that Rab proteins mediate communication between diverse cargoes and substrates through vesicular trafficking and secretion pathways in the tumor microenvironment. This review focuses on the role and regulation of vesicular secretion pathways in the tumor microenvironment, and describes the latest research advances and future directions.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Cell Biology
Ming-Jer Young, Yung-Ching Chen, Shao-An Wang, Hui-Ping Chang, Wen-Bin Yang, Chia-Chi Lee, Chia-Yu Liu, Yau-Lin Tseng, Yi-Ching Wang, H. Sunny Sun, Wen-Chang Chang, Jan-Jong Hung
Summary: Decreased Sp1 levels in lung cancer are associated with poor prognosis and are related to estrogen. It has been found that E2 can decrease Sp1 levels by increasing the expression of RNF4, and ultimately lead to malignancy in lung cancer.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)