Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity

An In Vitro Model for Neuroscience: Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons

(2017) Lotta Agholme et al.   JOURNAL OF ALZHEIMERS DISEASE

A Fibril-Like Assembly of Oligomers of a Peptide Derived from β-Amyloid

(2014) Johnny D. Pham et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

(2014) Georg Meisl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrasonic force microscopy for nanomechanical characterization of early and late-stage amyloid-β peptide aggregation

(2014) Claire Tinker-Mill et al.   Scientific Reports

Designed α-sheet peptides inhibit amyloid formation by targeting toxic oligomers

(2014) Gene Hopping et al.   eLife

Tanshinones Inhibit Amyloid Aggregation by Amyloid-β Peptide, Disaggregate Amyloid Fibrils, and Protect Cultured Cells

(2013) Qiuming Wang et al.   ACS Chemical Neuroscience

Nanomaterials for Reducing Amyloid Cytotoxicity

(2013) Min Zhang et al.   ADVANCED MATERIALS

A validated LC-MS/MS method for rapid determination of brazilin in rat plasma and its application to a pharmacokinetic study

(2013) Zhipeng Deng et al.   BIOMEDICAL CHROMATOGRAPHY

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

Carnosine Inhibits Aβ42Aggregation by Perturbing the H-Bond Network in and around the Central Hydrophobic Cluster

(2013) Francesco Attanasio et al.   CHEMBIOCHEM

Isobavachalcone and bavachinin fromPsoraleae Fructusmodulate Aβ42 aggregation process through different mechanisms in vitro

(2013) Xiumin Chen et al.   FEBS LETTERS

Application of a liquid chromatography–tandem mass spectrometry method to the pharmacokinetics, tissue distribution and excretion studies of brazilin in rats

(2013) Yanyan Jia et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

A simple high-performance liquid chromatographic method for the determination of brazilin and its application to a pharmacokinetic study in rats

(2013) Jia Yan-yan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease

(2013) Chuanjun Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Mechanistic Insight into the Molecular Basis of Amyloid Polymorphism and Secondary Nucleation during Amyloid Formation

(2013) Jae Sun Jeong et al.   JOURNAL OF MOLECULAR BIOLOGY

Toward the Molecular Mechanism(s) by Which EGCG Treatment Remodels Mature Amyloid Fibrils

(2013) Fernando L. Palhano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β pathways

(2013) Shengquan Hu et al.   NEUROCHEMISTRY INTERNATIONAL

Molecular interactions of Alzheimer amyloid-β oligomers with neutral and negatively charged lipid bilayers

(2013) Xiang Yu et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation

(2013) Luke A. Miles et al.   Scientific Reports

Neurotoxic amyloid beta oligomeric assemblies recreated in microfluidic platform with interstitial level of slow flow

(2013) Yoon Jung Choi et al.   Scientific Reports

Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms

(2012) Tingyu Liu et al.   ChemMedChem

Two-Step Nucleation of Amyloid Fibrils: Omnipresent or Not?

(2012) Stefan Auer et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular basis of  -amyloid oligomer recognition with a conformational antibody fragment

(2012) I. Morgado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrophobic, Aromatic, and Electrostatic Interactions Play a Central Role in Amyloid Fibril Formation and Stability

(2011) Karen E. Marshall et al.   BIOCHEMISTRY

Rational Design of β-Sheet Ligands Against Aβ42-Induced Toxicity

(2011) Katrin Hochdörffer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

(2011) Jan Bieschke et al.   Nature Chemical Biology

Structural, morphological, and kinetic studies of β-amyloid peptide aggregation on self-assembled monolayers

(2011) Qiuming Wang et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Association Thermodynamics and Conformational Stability of β-Sheet Amyloid β(17-42) Oligomers: Effects of E22Q (Dutch) Mutation and Charge Neutralization

(2010) Nikolay Blinov et al.   BIOPHYSICAL JOURNAL

Resveratrol Selectively Remodels Soluble Oligomers and Fibrils of Amyloid Aβ into Off-pathway Conformers

(2010) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural products as a source of Alzheimer's drug leads

(2010) Philip Williams et al.   NATURAL PRODUCT REPORTS

Preparation and characterization of toxic Aβ aggregates for structural and functional studies in Alzheimer's disease research

(2010) Asad Jan et al.   Nature Protocols

Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils

(2010) Mahiuddin Ahmed et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Characterization of a Soluble Amyloid β-Peptide Oligomer

(2009) Liping Yu et al.   BIOCHEMISTRY

Optimized Turmeric Extracts have Potent Anti-Amyloidogenic Effects

(2009) R. Shytle et al.   Current Alzheimer Research

Effect of pathogenic mutations on the structure and dynamics of Alzheimer’s Aβ42-amyloid oligomers

(2009) Kristin Kassler et al.   JOURNAL OF MOLECULAR MODELING

Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

(2009) Richard J. Perrin et al.   NATURE

Virtual Screening Using PLS Discriminant Analysis and ROC Curve Approach: An Application Study on PDE4 Inhibitors

(2008) Andrea Rizzi et al.   Journal of Chemical Information and Modeling

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY