Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen

Studies on Deacetoxycephalosporin C Synthase Support a Consensus Mechanism for 2-Oxoglutarate Dependent Oxygenases

(2014) Hanna Tarhonskaya et al.   BIOCHEMISTRY

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Hypoxia-inducible factor prolyl 4-hydroxylases: common and specific roles

(2013) Johanna Myllyharju et al.   BIOLOGICAL CHEMISTRY

Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO)

(2013) WeiShen Aik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase

(2012) Elena M. Sánchez-Fernández et al.   BIOCHEMICAL JOURNAL

Inverse Solvent Isotope Effects Demonstrate Slow Aquo Release from Hypoxia Inducible Factor-Prolyl Hydroxylase (PHD2)

(2012) Shannon C. Flagg et al.   BIOCHEMISTRY

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

(2012) WeiShen Aik et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Reporter Ligand NMR Screening Method for 2-Oxoglutarate Oxygenase Inhibitors

(2012) Ivanhoe K. H. Leung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors

(2011) Ya-Min Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxygen Sensing, Homeostasis, and Disease

(2011) Gregg L. Semenza   NEW ENGLAND JOURNAL OF MEDICINE

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents

(2010) Emily Flashman et al.   BIOCHEMICAL JOURNAL

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

(2010) Emily Flashman et al.   FEBS Journal

Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss

(2010) Y. A. Minamishima et al.   SCIENCE

Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues

(2010) Mark D. Rosen et al.   ACS Medicinal Chemistry Letters

Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2

(2009) Jasmin Mecinović et al.   ANALYTICAL BIOCHEMISTRY

Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2

(2009) Megan L. Matthews et al.   BIOCHEMISTRY

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing

(2009) James D. Webb et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Using NMR Solvent Water Relaxation to Investigate Metalloenzyme−Ligand Binding Interactions

(2009) Ivanhoe K. H. Leung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases

(2009) Rasheduzzaman Chowdhury et al.   STRUCTURE

Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology

(2008) Jennifer H. Dao et al.   ANALYTICAL BIOCHEMISTRY

The human oxygen sensing machinery and its manipulation

(2008) Rasheduzzaman Chowdhury et al.   CHEMICAL SOCIETY REVIEWS

Evidence That Two Enzyme-derived Histidine Ligands Are Sufficient for Iron Binding and Catalysis by Factor Inhibiting HIF (FIH)

(2008) Kirsty S. Hewitson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

PHD2Mutation and Congenital Erythrocytosis with Paraganglioma

(2008) Charline Ladroue et al.   NEW ENGLAND JOURNAL OF MEDICINE