Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure

(2012) Xavier Brazzolotto et al.   FEBS Journal

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

(2012) Jonah Cheung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genome Organization, Phylogenies, Expression Patterns, and Three-Dimensional Protein Models of Two Acetylcholinesterase Genes from the Red Flour Beetle

(2012) Yanhui Lu et al.   PLoS One

New Huprine Derivatives Functionalized at Position 9 as Highly Potent Acetylcholinesterase Inhibitors

(2011) Cyril Ronco et al.   ChemMedChem

Huprine Derivatives as Sub-Nanomolar Human Acetylcholinesterase Inhibitors: From Rational Design to Validation by X-ray Crystallography

(2011) Cyril Ronco et al.   ChemMedChem

Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease

(2011) Rafael León et al.   MEDICINAL RESEARCH REVIEWS

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Tacrine Derivatives and Alzheimers Disease

(2010) V. Tumiatti et al.   CURRENT MEDICINAL CHEMISTRY

Structural Evidence That Human Acetylcholinesterase Inhibited by Tabun Ages through O-Dealkylation

(2010) Eugénie Carletti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Soluble monomeric acetylcholinesterase from mouse: Expression, purification, and crystallization in complex with fasciculin

(2010) Pascale Marchot et al.   PROTEIN SCIENCE

Treatment of Alzheimer's disease in the long-term-care setting

(2009) D. A. Smith   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Pyrano[3,2-c]quinoline−6-Chlorotacrine Hybrids as a Novel Family of Acetylcholinesterase- and β-Amyloid-Directed Anti-Alzheimer Compounds

(2009) Pelayo Camps et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effects of cholinesterase inhibition on brain white matter volume in Alzheimerʼs disease

(2009) Annalena Venneri et al.   NEUROREPORT

Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel

(2008) Florian Nachon et al.   FEBS Journal

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY