A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery

A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets

(2012) Joost CM Uitdehaag et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

(2012) Michael J. Lee et al.   CELL

Selective killing of p53-deficient cancer cells by SP600125

(2012) Mohamed Jemaà et al.   EMBO Molecular Medicine

DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells

(2012) Naoe Taira et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery and Development of Spleen Tyrosine Kinase (SYK) Inhibitors

(2012) Rajinder Singh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

(2012) Arvin C. Dar et al.   NATURE

PAS Kinase Promotes Cell Survival and Growth Through Activation of Rho1

(2012) C. M. Cardon et al.   Science Signaling

PAS kinase: Integrating nutrient sensing with nutrient partitioning

(2012) Caleb M. Cardon et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling

(2011) Arvin C. Dar et al.   Annual Review of Biochemistry

Identification of DNA methylation changes associated with human gastric cancer

(2011) Jung-Hoon Park et al.   BMC Medical Genomics

In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases

(2011) Matthew P. Patricelli et al.   CHEMISTRY & BIOLOGY

Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN

(2011) Philipp Schläfli et al.   FEBS Journal

Inhibition of c-Jun-N-terminal Kinase Increases Cardiac Peroxisome Proliferator-activated Receptor α Expression and Fatty Acid Oxidation and Prevents Lipopolysaccharide-induced Heart Dysfunction

(2011) Konstantinos Drosatos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a–dependent neurite outgrowth

(2011) Yoshimi Endo Greer et al.   JOURNAL OF CELL BIOLOGY

Identifying Compound-Target Associations by Combining Bioactivity Profile Similarity Search and Public Databases Mining

(2011) Tiejun Cheng et al.   Journal of Chemical Information and Modeling

 2 Integrin Induces TCR -Syk-Phospholipase C-  Phosphorylation and Paxillin-Dependent Granule Polarization in Human NK Cells

(2011) M. E. March et al.   JOURNAL OF IMMUNOLOGY

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

(2011) Theonie Anastassiadis et al.   NATURE BIOTECHNOLOGY

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin

(2011) D Huertas et al.   ONCOGENE

Spleen tyrosine kinases: biology, therapeutic targets and drugs

(2010) Mauro Riccaboni et al.   DRUG DISCOVERY TODAY

The (un)targeted cancer kinome

(2010) Oleg Fedorov et al.   Nature Chemical Biology

The art of the chemical probe

(2010) Stephen V Frye   Nature Chemical Biology

A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model

(2010) A. S. Tsvetkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis

(2010) Fangwei Wang et al.   SCIENCE

Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation: Table 1

(2009) Philip Cohen   BIOCHEMICAL JOURNAL

Spleen Tyrosine Kinase Is Overexpressed and Represents a Potential Therapeutic Target in Chronic Lymphocytic Leukemia

(2009) Maike Buchner et al.   CANCER RESEARCH

Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase

(2009) Kenji Takeuchi et al.   FEBS Journal

Critical Role of Nuclear Calcium/Calmodulin-dependent Protein Kinase IIδB in Cardiomyocyte Survival in Cardiomyopathy

(2009) Gillian H. Little et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomics strategy for quantitative protein interaction profiling in cell extracts

(2009) Kirti Sharma et al.   NATURE METHODS

Mutations at the BLK locus linked to maturity onset diabetes of the young and  -cell dysfunction

(2009) M. Borowiec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

The c-Jun N-terminal kinase pathway is critical for cell transformation by the latent membrane protein 1 of Epstein–Barr virus

(2007) Helmut Kutz et al.   VIROLOGY