期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 23, 期 6, 页码 626-630出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2011.12.007
关键词
Nutrient; Growth; PAS kinase; AMPK; TOR
资金
- NIDDK NIH HHS [R01 DK071962, R01 DK071962-06] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007464] Funding Source: Medline
Recent data suggests that PAS kinase acts as a signal integrator to adjust metabolic behavior in response to nutrient conditions. Specifically, PAS kinase controls the partitioning of nutrient resources between the myriad of possible fates. In this capacity, PAS kinase elicits a pro-growth program, which includes both signaling and metabolic control, both in yeast and in mammals. We propose that, like other kinases possessing these properties-AMPK and TOR, PAS kinase might be target for therapy of diabetes, obesity and cancer. (C) 2012 Elsevier Ltd. All rights reserved.
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