SR4 Uncouples Mitochondrial Oxidative Phosphorylation, Modulates AMP-dependent Kinase (AMPK)-Mammalian Target of Rapamycin (mTOR) Signaling, and Inhibits Proliferation of HepG2 Hepatocarcinoma Cells

Regorafenib impairs mitochondrial functions, activates AMP-activated protein kinase, induces autophagy, and causes rat hepatocyte necrosis

(2015) Zuquan Weng et al.   TOXICOLOGY

Mitochondrial uncoupling proteins and energy metabolism

(2015) Rosa A. Busiello et al.   Frontiers in Physiology

Clusianone, a naturally occurring nemorosone regioisomer, uncouples rat liver mitochondria and induces HepG2 cell death

(2014) Felippe H.Z. Reis et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Hepatocellular Carcinoma: Reasons for Phase III Failure and Novel Perspectives on Trial Design

(2014) J. M. Llovet et al.   CLINICAL CANCER RESEARCH

Antiproliferative and Uncoupling Effects of Delocalized, Lipophilic, Cationic Gallic Acid Derivatives on Cancer Cell Lines. Validation in Vivo in Singenic Mice

(2014) José A. Jara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combined Cancer Therapy with Non-Conventional Drugs: All Roads Lead to AMPK

(2014) Suning Chen et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

BoxPlotR: a web tool for generation of box plots

(2014) Michaela Spitzer et al.   NATURE METHODS

Novel compound 1,3-bis (3,5-dichlorophenyl) urea inhibits lung cancer progression

(2013) Sharad S. Singhal et al.   BIOCHEMICAL PHARMACOLOGY

Dodecyl and octyl esters of fluorescein as protonophores and uncouplers of oxidative phosphorylation in mitochondria at submicromolar concentrations

(2013) Maria M. Shchepinova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A Prototypical Small-Molecule Modulator Uncouples Mitochondria in Response to Endogenous Hydrogen Peroxide Production

(2013) Stephen J. McQuaker et al.   CHEMBIOCHEM

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

Data, information, knowledge and principle: back to metabolism in KEGG

(2013) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane

(2013) Brandon M. Kenwood et al.   Molecular Metabolism

Mitochondrial Uncoupling and the Reprograming of Intermediary Metabolism in Leukemia Cells

(2013) Juliana Vélez et al.   Frontiers in Oncology

Mitochondrial Dysfunction in Cancer

(2013) Michelle L. Boland et al.   Frontiers in Oncology

1,3-Bis(3,5-dichlorophenyl) urea compound ‘COH-SR4’ inhibits proliferation and activates apoptosis in melanoma

(2012) Sharad S. Singhal et al.   BIOCHEMICAL PHARMACOLOGY

Targeting cancer cell mitochondria as a therapeutic approach

(2012) Shijun Wen et al.   Future Medicinal Chemistry

Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma

(2012) Hashem B. El-Serag   GASTROENTEROLOGY

Classification of mitocans, anti-cancer drugs acting on mitochondria

(2012) Jiri Neuzil et al.   MITOCHONDRION

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

(2011) Ken Inoki et al.   Annual Review of Pharmacology and Toxicology

Anticancer Drugs Targeting the Mitochondrial Electron Transport Chain

(2011) Jakub Rohlena et al.   ANTIOXIDANTS & REDOX SIGNALING

Diabetes mellitus and risk of hepatocellular carcinoma: a systematic review and meta-analysis

(2011) Ping Wang et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Novel dichlorophenyl urea compounds inhibit proliferation of human leukemia HL-60 cells by inducing cell cycle arrest, differentiation and apoptosis

(2011) James L. Figarola et al.   INVESTIGATIONAL NEW DRUGS

Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore

(2011) Susan Chalmers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Regulation and Physiology of Mitochondrial Proton Leak

(2011) Ajit S. Divakaruni et al.   PHYSIOLOGY

High Throughput Microplate Respiratory Measurements Using Minimal Quantities Of Isolated Mitochondria

(2011) George W. Rogers et al.   PLoS One

Bupivacaine uncouples the mitochondrial oxidative phosphorylation, inhibits respiratory chain complexes I and III and enhances ROS production: Results of a study on cell cultures

(2010) Olga Cela et al.   MITOCHONDRION

The anti-cancer agent nemorosone is a new potent protonophoric mitochondrial uncoupler

(2010) Gilberto L. Pardo-Andreu et al.   MITOCHONDRION

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Cancer as a metabolic disease

(2010) Thomas N Seyfried et al.   Nutrition & Metabolism

Beyond Costs and Benefits: Understanding How Patients Make Health Care Decisions

(2010) P. A. Ubel   ONCOLOGIST

Mitochondrial Uncoupling and the Warburg Effect: Molecular Basis for the Reprogramming of Cancer Cell Metabolism

(2009) I. Samudio et al.   CANCER RESEARCH

Small mitochondria-targeting molecules as anti-cancer agents

(2009) Feng Wang et al.   MOLECULAR ASPECTS OF MEDICINE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Effects of carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone on the growth inhibition in human pulmonary adenocarcinoma Calu-6 cells

(2009) Yong Hwan Han et al.   TOXICOLOGY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

2,4-Dinitrophenol induces G1 phase arrest and apoptosis in human pulmonary adenocarcinoma Calu-6 cells

(2007) Yong Hwan Han et al.   TOXICOLOGY IN VITRO