期刊
CHEMBIOCHEM
卷 14, 期 8, 页码 993-1000出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201300115
关键词
antioxidants; bioorganic chemistry; drug delivery; mitochondria; prodrugs
资金
- Lloyds TSB Foundation for Scotland
- Royal Society of Edinburgh
- NIH [R01 AG033542, P01 AG025901, TL1 AG032116]
- Wellcome Trust [WT092292/B/10/Z]
A high membrane potential across the mitochondrial inner membrane leads to the production of the reactive oxygen species (ROS) implicated in aging and age-related diseases. A prototypical drug for the correction of this type of mitochondrial dysfunction is presented. MitoDNP-SUM accumulates in mitochondria in response to the membrane potential due to its mitochondria-targeting alkyltriphenylphosphonium (TPP) cation and is uncaged by endogenous hydrogen peroxide to release the mitochondrial uncoupler, 2,4-dinitrophenol (DNP). DNP is known to reduce the high membrane potential responsible for the production of ROS. The approach potentially represents a general method for the delivery of drugs to the mitochondrial matrix through mitochondria targeting and H2O2-induced uncaging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据