Article
Surgery
Ayca Ergan Sahin, Aysin Karasoy Yesilada, Ozben Yalcin, Eray M. Guler, Harun Erbek, Damla Karabiyik
Summary: The study shows that treatment with HRS solution can reduce edema and inflammation in rats with degloving injuries, as well as having antioxidant and angiogenic effects.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Article
Surgery
Hayrunnisa Oral, Zafer Turkyilmaz, Ramazan Karabulut, Cem Kaya, Duygu Dayanir, Cengiz Karakaya, Kaan Sonmez
Summary: This study found that hydrogen rich saline solution (HRSS) can protect the intestines from damage caused by ischemia-reperfusion injury in experimental intestinal volvulus in rats.
JOURNAL OF INVESTIGATIVE SURGERY
(2022)
Article
Cell Biology
Zeyu Li, Ben Wang, Lifei Tian, Bobo Zheng, Xu Zhao, Ruiting Liu
Summary: This study investigates the protective effect of methane saline (MS) on intestinal ischemia-reperfusion (I/R) injury and its potential mechanisms. The results show that MS pretreatment ameliorates intestinal barrier damage after I/R injury by suppressing NLRP3-mediated pyroptosis. MS treatment also reduces the formation of mitochondria-associated membrane (MAM) and alleviates endoplasmic reticulum (ER) stress, thereby inhibiting the activation of NLRP3.
Article
Pharmacology & Pharmacy
Huijiao Lin, Xinyun Zhang, Dan Wang, Jiawei Liu, Liwei Yuan, Jiale Liu, Chunmei Wang, Jinghui Sun, Jianguang Chen, He Li, Shu Jing
Summary: Anwulignan can alleviate jejunal tissue injury caused by II/R in rats by activating the PI3K/protein kinase B pathway and regulating the Nrf2/Anti-oxidative Response Element signaling pathway and the expression of apoptosis-related proteins to play antioxidant and antiapoptotic roles.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Gaizka Gutierrez-Sanchez, Ignacio Garcia-Alonso, Jorge Gutierrez Saenz de Santa Maria, Ana Alonso-Varona, Borja Herrero de la Parte
Summary: The study found that nitroindazole has a preventive/protective effect against intestinal tissue damage in the early stages of intestinal ischemia-reperfusion injury (i-IRI), reducing the extent of damage, and showing significant effects in both 1 and 2-hour ischemia periods. More research is needed to better understand the molecular mechanisms underlying this phenomenon.
Review
Medicine, Research & Experimental
Lini Quan, Bin Zheng, Huacheng Zhou
Summary: Hydrogen molecule (H-2) as a potential selective antioxidant can improve outcomes in lung transplantation by reducing oxidative stress and inflammation, thus alleviating transplantation-related lung injury. Further research is needed to fully understand the mechanisms of H-2 and its potential use as a treatment in clinical settings.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mulin Liu, Hexin Wen, Lugen Zuo, Xue Song, Zhijun Geng, Sitang Ge, Yuanyuan Ge, Rong Wu, Shiyuan Chen, Chaowen Yu, Yong Gao
Summary: This study investigated the effects of Bryo-1 on intestinal ischemia/reperfusion (I/R) injury and its mechanism. The results showed that Bryo-1 improved the intestinal barrier dysfunction caused by I/R, reduced oxidative stress damages and inflammation, and activated Nrf2/HO-1 signaling. These findings suggest that Bryo-1 protects intestines against I/R-induced injury through intestinal barrier protection and inhibition of inflammation and oxidative stress partly via Nrf2/HO-1 signaling.
Article
Biochemistry & Molecular Biology
Gustavo Sampaio de Holanda, Samuel dos Santos Valenca, Amabile Maran Carra, Renata Cristina Lopes Lichtenberger, Bianca de Castilho, Olavo Borges Franco, Joao Alfredo de Moraes, Alberto Schanaider
Summary: Acute mesenteric ischemia and reperfusion injury is a complex and lethal mechanism involving disruption of cellular microcirculation and mitochondrial damage. Fluorescent molecular probes have been shown to be highly efficient in monitoring the concentrations and locations of ROS and RNS.
Article
Neurosciences
Yahong Liu, Ying Cheng, Wei Zhang, Hongqi Tian
Summary: HL-008 shows significant neuroprotective effects in cerebral ischemia-reperfusion injury by modulating brain tissue apoptosis, inflammation, and oxidative stress through multiple signaling pathways, potentially improving the quality of life for stroke patients.
Review
Cell Biology
Shuangyu Lv, Xiaotian Li, Shizhen Zhao, Huiyang Liu, Honggang Wang
Summary: Ischemia/reperfusion (I/R) injury refers to the changes in functional and structural changes during blood flow recovery after ischemia. Myocardial I/R injury, aggravated by sudden blood circulation disorder, is still not fully understood despite numerous studies. Hydrogen sulfide (H2S) has shown potential in improving myocardial I/R injury, but the underlying signal pathways remain unclear, warranting further research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lile Dong, Lianhong Yin, Ruomiao Li, Lina Xu, Youwei Xu, Xu Han, Yan Qi
Summary: Dioscin has shown protective effects against lung ischemia/reperfusion injury by regulating the FXR/LKB1 signaling pathway to reduce oxidative stress, apoptosis, and inflammation levels, making it a potential candidate for treating LI/RI.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mathias Clarysse, Alison Accarie, Arnau Panisello-Rosello, Ricard Farre, Emilio Canovai, Diethard Monbaliu, Gert De Hertogh, Tim Vanuytsel, Jacques Pirenne, Laurens J. Ceulemans
Summary: Intestinal ischemia-reperfusion injury (IRI) is a common clinical condition with unpredictable outcomes. Polyethylene glycol (PEG), a commonly used excipient, has been found to have anti-inflammatory and cell-membrane-stabilizing properties. This study investigated the effects of PEG administration on IRI in rats and found that it reduced reperfusion edema, bacterial translocation, inflammatory reaction, and improved survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Gustavo Sampaio de Holanda, Samuel dos Santos Valenca, Amabile Maran Carra, Renata Cristina Lopes Lichtenberger, Olavo Borges Franco, Beatriz Elias Ribeiro, Siane Lopes Bittencourt Rosas, Patricia Teixeira Santana, Morgana Teixeira Lima Castelo-Branco, Heitor Siffert Pereira de Souza, Alberto Schanaider
Summary: The study demonstrated that albumin and sulforaphane administered systemically can attenuate intestinal ischemia-reperfusion injury by reducing oxidative stress, thereby reducing damage and protecting gastrointestinal cells.
JOURNAL OF SURGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Tamara Merz, Oscar McCook, Cosima Brucker, Christiane Waller, Enrico Calzia, Peter Radermacher, Thomas Datzmann
Summary: The discovery of endogenous H2S with cytoprotective properties has led to efforts in developing H2S as a therapeutic agent. H2S's ability to regulate various processes makes it potentially useful in managing critical illnesses. However, current methods of delivering H2S are not feasible for clinical use. Na2S2O3, a clinically approved compound, shows promise in pre-clinical studies for managing critical illnesses. Clinical trials are investigating its potential in myocardial infarction, and it may also be relevant for pre-eclampsia and COVID-19 pneumonia.
Review
Biochemistry & Molecular Biology
Fan Deng, Ze-Bin Lin, Qi-Shun Sun, Yue Min, Yue Zhang, Yu Chen, Wen-Ting Chen, Jing-Juan Hu, Ke-Xuan Liu
Summary: Intestinal ischemia/reperfusion (I/R) is a common pathological process in severely ill patients, and the impact of intestinal I/R injury on the overall systemic state of the patient is greater than that of primary intestinal injury. Recent evidence suggests that intestinal microbiota and its metabolites play a crucial role in the occurrence, development, diagnosis, and treatment of intestinal I/R injury. Targeting the intestinal microbiota and its metabolites may be an effective therapy for treating intestinal I/R injury and associated extraintestinal organ injuries.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Endocrinology & Metabolism
Richard Camara, Nathanael Matei, John H. Zhang
Summary: Although many patients are not eligible for reperfusion within 24 hours according to current guidelines, case studies show favorable outcomes for delayed recanalization beyond 24 hours after symptom onset. Modern imaging techniques aid in identifying penumbra and improving understanding of reperfusion risks and complications. There is an urgent need to further comprehend the pathophysiologic mechanisms and optimal conditions for delayed recanalization after 24 hours of ischemia.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Cell Biology
Shengpeng Liu, Jerry J. Flores, Bo Li, Shuixiang Deng, Gang Zuo, Jun Peng, Jiping Tang, John H. Zhang
Summary: This study found that rIL-19 treatment improved hematoma clearance and reduced neurological deficits after GMH by upregulating the IL-20R1/ERK/Nrf2 signaling pathway, suggesting a promising therapeutic strategy for GMH patients.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Qin Zhang, Mei Zheng, Cristian E. Betancourt, Lifeng Liu, Albert Sitikov, Nikola Sladojevic, Qiong Zhao, John H. Zhang, James K. Liao, Rongxue Wu
Summary: The study found that MMP3 affects the permeability of the BBB through upregulation of the ERK signaling pathway, leading to a decrease in TJ and VE-cadherin proteins in BMVECs.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Cell Biology
Li Li, Cameron Lenahan, Zhihui Liao, Jingdong Ke, Xiuliang Li, Fushan Xue, John H. Zhang
Summary: The immune system plays a crucial role in brain damage and recovery, but the biology of immune response in the brain is still poorly understood due to the complexity of the central nervous system and technological limitations. Novel technologies such as single-cell RNA analysis and cytometry by time-of-flight are being utilized to study brain immune response and may provide a promising future for brain repair.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Shufeng Yu, Desislava Met Doycheva, Marcin Gamdzyk, Yuanyuan Gao, Yong Guo, Zackary D. Travis, Jiping Tang, Wen-Xiong Chen, John H. Zhang
Summary: The activation of MC1R with BMS-470539 attenuates oxidative stress and neuronal apoptosis in a neonatal HI rat model, improving neurological deficits. This effect is partially mediated by the MC1R/cAMP/PKA/Nurr1 signaling pathway.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Nanoscience & Nanotechnology
Caiyou Zeng, Xuejun Sun, Bojin Qi, Yipeng Wang, Haibo Wang, Zhejun Tan, Yong Peng, Baoqiang Cong
Summary: This study demonstrates a novel strategy to enhance the strength and ductility of AA2219 Al-6.3Cu alloy arc-welded joints by introducing TiC particles and using a distinctive ultrasonic frequency double-pulsed arc. The fabricated TiCp/Al6.3Cu joint shows a fine-grained structure and a hierarchical alpha-Al grain structure embedded with dense nano-precipitation. The joint exhibits an unprecedented joint coefficient and excellent mechanical performance.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Cell Biology
Xuan Shi, Lina Zhu, Sheng Wang, Wanli Zhu, Quanfu Li, Juan Wei, Di Feng, Meiyun Liu, Yuanli Chen, Xuejun Sun, Hongtao Lu, Xin Lv
Summary: This study explored the protective effects of magnesium hydride (MgH2) on two types of ARDS models and its underlying mechanism in a lipopolysaccharide (LPS)-induced ARDS model of the A549 cell line. Results showed that MgH2 exerted anti-inflammatory, antioxidant, anti-apoptotic, and barrier-protective effects by regulating molecular signaling pathways. The in vivo study also demonstrated that MgH2-treated mice had a better survival rate and less pathological damage.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Pharmacology & Pharmacy
Xiaoya Li, Xueqi Ma, Xintong Chen, Tingfang Wang, Qing Liu, Yongfang Wang, Zhezhe Li, Juan Hofer, Fangbing Li, Liang Xiao, Xuejun Sun, Jinggang Mo
Summary: This study analyzed the molecular composition of the medusa and polyp of Aurelia coerulea and compared its toxicity with another scyphozoan jellyfish, Stomolophus meleagris. The results showed that A. coerulea medusae and polyps have similar molecular compositions, but their gene expressions are significantly different. A. coerulea medusa displayed weaker toxicity compared to S. meleagris medusa, and the variation in toxin expressions may be an important factor contributing to the difference in toxicity.
Article
Cell Biology
Jinwei Pang, Nathanael Matei, Jianhua Peng, Wen Zheng, Jing Yu, Xu Luo, Richard Camara, Ligang Chen, Jiping Tang, John H. Zhang, Yong Jiang
Summary: Delayed recanalization at day 3 postinfarct can significantly improve neurological outcomes after ischemic stroke. Macrophages play a critical role in this process by promoting angiogenesis and reducing neurodegeneration.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Engineering, Manufacturing
Xuejun Sun, Bojin Qi, Zihao Jiang, Caiyou Zeng, Baoqiang Cong
Summary: In this study, different current modes were used to butt-weld 1460 Al-Li alloy plates. The effects of these current modes on the weld microstructure and mechanical properties were compared. The results showed that modulating pulsed current can refine the grains in the weld zone and fusion zone, and significantly increase the quantity and width of a fine strip-like equiaxed grain zone. Both P-VPTIG and DP-VPTIG processes effectively enhanced the strength and elongation of the joints.
JOURNAL OF MANUFACTURING PROCESSES
(2022)
Article
Economics
Jingpei Ma, Xuejun Sun
Summary: The development of green technology allows manufacturers in traditional industries to reduce carbon emissions, but the adoption of this technology varies among manufacturers. By implementing an effective green technology licensing strategy, highly efficient manufacturers can share their technology with less efficient manufacturers. The government has introduced subsidies to promote the use of green technology among manufacturers. However, the effectiveness of these subsidies, especially in the face of intense market competition, is still uncertain. This study develops a game theory model to analyze the optimal subsidy policy for the government.
MANAGERIAL AND DECISION ECONOMICS
(2023)
Editorial Material
Medicine, Research & Experimental
Xuejun Sun, Shigeo Ohta, John H. Zhang
MEDICAL GAS RESEARCH
(2023)
Article
Endocrinology & Metabolism
Chensheng Le, Xin Hu, Lusha Tong, Xianghua Ye, Junyi Zhang, Jun Yan, Prativa Sherchan, John H. Zhang, Feng Gao, Jiping Tang
Summary: This study investigated the role of LAR in neuroinflammation after intracerebral hemorrhage (ICH) using a mouse model. The results showed that LAR contributed to neuroinflammation after ICH via the RhoA/IRS-1 pathway, and the inhibitor ELP may be a potential therapeutic strategy to attenuate LAR-mediated neuroinflammation after ICH.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Clinical Neurology
Ben Gaastra, John Zhang, Will Tapper, Diederik Bulters, Ian Galea
Summary: Sphingosine-1-phosphate (S1P) plays a role in the pathophysiology of neurological injury after aneurysmal subarachnoid haemorrhage (aSAH). The literature agrees that S1P increases in cerebrospinal fluid following aSAH and contributes to cerebral artery vasospasm. However, the role of S1P in the parenchyma is less clear, with conflicting studies suggesting both beneficial and harmful effects. This review provides a concise interpretation of the conflicting data and discusses the potential repurposing of S1P receptor modulators for aSAH.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Engineering, Biomedical
Jing Ma, Suhe Dong, Hongtao Lu, Zhongmin Chen, Huijie Yu, Xuejun Sun, Renjun Peng, Wei Li, Sinian Wang, Qisheng Jiang, Fengsheng Li, Li Ma
Summary: This study revealed the protective effect of MgH2, a hydrogen storage nanomaterial, on radiation-induced male fertility impairment. MgH2 improved testicular structure, sperm quality, genetic effect, spermatogenesis, and hormone secretion. It also eliminated free radicals, suppressed ROS production, alleviated oxidative stress, and inhibited apoptosis and inflammation induced by radiation.
BIOMATERIALS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
