Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells

The autophagy geneATG5plays an essential role in B lymphocyte development

(2014) Brian C. Miller et al.   Autophagy

Dual Role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation

(2014) Yongjie Wei et al.   Autophagy

Autophagy at sea

(2013) Sascha Martens et al.   Autophagy

p62 expression and autophagy in αB-crystallin R120G mutant knock-in mouse model of hereditary cataract

(2013) Jonathan A. Wignes et al.   EXPERIMENTAL EYE RESEARCH

Autophagy and mitophagy participate in ocular lens organelle degradation

(2013) M. Joseph Costello et al.   EXPERIMENTAL EYE RESEARCH

Deletion of Autophagy-related 5 (Atg5) andPik3c3Genes in the Lens Causes Cataract Independent of Programmed Organelle Degradation

(2013) Hideaki Morishita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis

(2013) Kelly Devereaux et al.   PLoS One

GSK-3β signaling determines autophagy activation in the breast tumor cell line MCF7 and inclusion formation in the non-tumor cell line MCF10A in response to proteasome inhibition

(2013) E Gavilán et al.   Cell Death & Disease

A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells

(2013) A D Kim et al.   Cell Death & Disease

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

A novel image-based cytometry method for autophagy detection in living cells

(2012) Leo Li-Ying Chan et al.   Autophagy

Induction of autophagy is essential for monocyte-macrophage differentiation

(2012) Y. Zhang et al.   BLOOD

Discovery of Potent and Selective Covalent Inhibitors of JNK

(2012) Tinghu Zhang et al.   CHEMISTRY & BIOLOGY

Insulin-like Growth Factor Receptor-1 and Nuclear Factor κB Are Crucial Survival Signals That Regulate Caspase-3-mediated Lens Epithelial Cell Differentiation Initiation

(2012) Subhasree Basu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osmotic Stress Regulates Mammalian Target of Rapamycin (mTOR) Complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor Protein Phosphorylation

(2012) Dongoh Kwak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy and cell growth - the yin and yang of nutrient responses

(2012) T. P. Neufeld   JOURNAL OF CELL SCIENCE

JNK-dependent Atg4 upregulation mediates asperphenamate derivative BBP-induced autophagy in MCF-7 cells

(2012) Yanchun Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mutations in FYCO1 Cause Autosomal-Recessive Congenital Cataracts

(2011) Jianjun Chen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting

(2011) Min Ni et al.   BIOCHEMICAL JOURNAL

Erufosine simultaneously induces apoptosis and autophagy by modulating the Akt–mTOR signaling pathway in oral squamous cell carcinoma

(2011) Vaishali Kapoor et al.   CANCER LETTERS

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

JNK regulates FoxO-dependent autophagy in neurons

(2011) P. Xu et al.   GENES & DEVELOPMENT

Autophagy regulates hypoxia-induced osteoclastogenesis through the HIF-1α/BNIP3 signaling pathway

(2011) Yi Zhao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Lens fibre cell differentiation and organelle loss: many paths lead to clarity

(2011) M. A. Wride   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Integrin-Dependent Activation of the JNK Signaling Pathway by Mechanical Stress

(2011) Andrea Maria Pereira et al.   PLoS One

A comprehensive glossary of autophagy-related molecules and processes

(2010) Daniel J. Klionsky et al.   Autophagy

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Autophagy in cellular growth control

(2010) Richard C. Wang et al.   FEBS LETTERS

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

Selective autophagy: ubiquitin-mediated recognition and beyond

(2010) Claudine Kraft et al.   NATURE CELL BIOLOGY

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway

(2010) X. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

TOR-dependent control of autophagy: biting the hand that feeds

(2009) Thomas P Neufeld   CURRENT OPINION IN CELL BIOLOGY

Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity Is Associated with Phosphorylation of Raptor by mTOR

(2009) Lifu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser863and Multisite Phosphorylation

(2009) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum Stress-Mediated Autophagy/Apoptosis Induced by Capsaicin (8-Methyl-N-vanillyl-6-nonenamide) and Dihydrocapsaicin is Regulated by the Extent of c-Jun NH2-Terminal Kinase/Extracellular Signal-Regulated Kinase Activation in WI38 Lung Epithelial Fibroblast Cells

(2009) S.-H. Oh et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

Discovery of Atg5/Atg7-independent alternative macroautophagy

(2009) Yuya Nishida et al.   NATURE

The autophagy effector Beclin 1: a novel BH3-only protein

(2009) S Sinha et al.   ONCOGENE

Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression

(2009) Jolene Bohensky et al.   PEDIATRIC NEPHROLOGY

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

(2009) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

The mTOR Signaling Network: Insights from Its Role During Embryonic Development

(2008) M. Hwang et al.   CURRENT MEDICINAL CHEMISTRY

Integrins in lens development and disease

(2008) Janice Walker et al.   EXPERIMENTAL EYE RESEARCH

On the mechanism of organelle degradation in the vertebrate lens

(2008) Steven Bassnett   EXPERIMENTAL EYE RESEARCH

Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease

(2008) N. Raben et al.   HUMAN MOLECULAR GENETICS

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

mTOR—What Does It Do?

(2008) M.N. Hall   TRANSPLANTATION PROCEEDINGS