A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells

Src Family Kinase Inhibitor PP2 Induces LC3 Conversion in a Manner That is Uncoupled from Autophagy and Increases Apoptosis in Multidrug-Resistant Cells

(2012) Yun-Ki Kim et al.   Biomolecules & Therapeutics

Sodium selenite-induced activation of DAPK promotes autophagy in human leukemia HL60 cells

(2012) Qian Jiang et al.   BMB Reports

Copper compound induces autophagy and apoptosis of glioma cells by reactive oxygen species and jnk activation

(2012) Cristina Trejo-Solís et al.   BMC CANCER

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis

(2012) L. Ouyang et al.   CELL PROLIFERATION

Anti-Cancer Effect of Ginsenoside F2against Glioblastoma Multiforme in Xenograft Model in SD Rats

(2012) Ji-Yon Shin et al.   Journal of Ginseng Research

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation

(2011) Chuan-Ming Xie et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy as a target for anticancer therapy

(2011) Filip Janku et al.   Nature Reviews Clinical Oncology

Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study

(2011) S Shen et al.   ONCOGENE

The role of reactive oxygen species and autophagy in safingol-induced cell death

(2011) L-U Ling et al.   Cell Death & Disease

Ginsenoside Rp1, a Ginsenoside Derivative, Blocks Promoter Activation of iNOS and COX-2 Genes by Suppression of an IKKβ-mediated NF-κB Pathway in HEK293 Cells

(2011) Ting Shen et al.   Journal of Ginseng Research

Targeting the pro-death and pro-survival functions of autophagy as novel therapeutic strategies in cancer

(2010) Kevin Dalby et al.   Autophagy

Crosstalk between apoptosis and autophagy within the Beclin 1 interactome

(2010) Maria Chiara Maiuri et al.   EMBO JOURNAL

Ginseng saponin metabolite induces apoptosis in MCF-7 breast cancer cells through the modulation of AMP-activated protein kinase

(2010) Areum Daseul Kim et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Compound K, a Metabolite of Ginseng Saponin, Induces Mitochondria-Dependent and Caspase-Dependent Apoptosis via the Generation of Reactive Oxygen Species in Human Colon Cancer Cells

(2010) In Kyung Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras

(2009) Joo-Yun Byun et al.   CARCINOGENESIS

Life and death partners: apoptosis, autophagy and the cross-talk between them

(2009) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

Effect of Compound K, a Metabolite of Ginseng Saponin, Combined with γ-Ray Radiation in Human Lung Cancer Cells in Vitro and in Vivo

(2009) Sungwook Chae et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Compound K Induces Apoptosis via CAMK-IV/AMPK Pathways in HT-29 Colon Cancer Cells

(2009) Do Yeon Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

OSU-03012, a Novel Celecoxib Derivative, Induces Reactive Oxygen Species-Related Autophagy in Hepatocellular Carcinoma

(2008) M. Gao et al.   CANCER RESEARCH

Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations

(2008) J LOPICCOLO et al.   DRUG RESISTANCE UPDATES

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells

(2008) D-D Li et al.   ONCOGENE