BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production

Enhanced Expression of EHMT2 Is Involved in the Proliferation of Cancer Cells through Negative Regulation of SIAH1

(2015) Hyun-Soo Cho et al.   NEOPLASIA

Autophagic cell death exists

(2012) Peter G.H. Clarke et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function

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Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery

(2011) Hiroyuki Katayama et al.   CHEMISTRY & BIOLOGY

Measuring EGSH and H2O2 with roGFP2-based redox probes

(2011) Bruce Morgan et al.   FREE RADICAL BIOLOGY AND MEDICINE

HDACs link the DNA damage response, processing of double-strand breaks and autophagy

(2011) Thomas Robert et al.   NATURE

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

(2011) Masoud Vedadi et al.   Nature Chemical Biology

A Switch Between Cytoprotective and Cytotoxic Autophagy in the Radiosensitization of Breast Tumor Cells by Chloroquine and Vitamin D

(2011) Eden N. Wilson et al.   Hormones & Cancer

Targeting the pro-death and pro-survival functions of autophagy as novel therapeutic strategies in cancer

(2010) Kevin Dalby et al.   Autophagy

Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma

(2010) Yuan-Ling Liu et al.   Autophagy

Anti-apoptosis and cell survival: A review

(2010) Liam Portt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Epigenetic cancer therapy: Proof of concept and remaining challenges

(2010) Cora Mund et al.   BIOESSAYS

Zinc(II) ion mediates tamoxifen-induced autophagy and cell death in MCF-7 breast cancer cell line

(2010) Jung Jin Hwang et al.   BIOMETALS

Targeting apoptotic and autophagic pathways for cancer therapeutics

(2010) Jun-jie Liu et al.   CANCER LETTERS

H3K9 Histone Methyltransferase G9a Promotes Lung Cancer Invasion and Metastasis by Silencing the Cell Adhesion Molecule Ep-CAM

(2010) M.-W. Chen et al.   CANCER RESEARCH

Methods in Mammalian Autophagy Research

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A Genome-Wide siRNA Screen Reveals Multiple mTORC1 Independent Signaling Pathways Regulating Autophagy under Normal Nutritional Conditions

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Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin

(2010) Doris Illner et al.   EXPERIMENTAL CELL RESEARCH

G9a and Glp Methylate Lysine 373 in the Tumor Suppressor p53

(2010) Jing Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Autophagy and Tumorigenesis

(2010) Srirupa Roy et al.   Seminars in Immunopathology

Oxidative stress promotes autophagic cell death in human neuroblastoma cells with ectopic transfer of mitochondrial PPP2R2B (Bβ2)

(2009) Wan-Ting Cheng et al.   BMC CELL BIOLOGY

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

(2009) Yanqi Chang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition

(2009) A Lakshmikuttyamma et al.   ONCOGENE

Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming

(2009) Wenlin Li et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Anticancer Agent Chaetocin Is a Competitive Substrate and Inhibitor of Thioredoxin Reductase

(2008) Jennifer D. Tibodeau et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

MCF-7 breast carcinoma cells do not express caspase-3

(2008) Reiner U. Jänicke   BREAST CANCER RESEARCH AND TREATMENT

Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct4 and Klf4 with Small-Molecule Compounds

(2008) Yan Shi et al.   Cell Stem Cell

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Downregulation of Histone H3 Lysine 9 Methyltransferase G9a Induces Centrosome Disruption and Chromosome Instability in Cancer Cells

(2008) Yutaka Kondo et al.   PLoS One