Review
Oncology
Francisco Gimeno-Valiente, Gerardo Lopez-Rodas, Josefa Castillo, Luis Franco
Summary: This review focuses on the interconnections between epigenetics and alternative splicing in the development of cancer. It discusses the mechanisms involved in these interconnections and the potential diagnostic and therapeutic tools that can be derived from them. The reversible nature of epigenetic alterations and the possibility of correcting aberrant alternative splicing offer promising therapeutic possibilities for cancer treatment.
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Review
Cell Biology
Dipanwita Das, Nandini Karthik, Reshma Taneja
Summary: Inflammation is a crucial immune response against infection and tissue damage, but chronic inflammation is linked to cancer development. Immune cells produce inflammatory mediators to facilitate tumor growth, while aberrant expression of inflammatory factors by tumor cells recruits immune cells for mutual crosstalk, creating a conducive environment for tumor growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Roberta Giordo, Anna Maria Posadino, Arduino Aleksander Mangoni, Gianfranco Pintus
Summary: An intricate interplay between genetic and environmental factors contributes to the development of type 2 diabetes (T2D) and its complications. Metformin, a derivative of biguanide, exerts pleiotropic effects through multiple epigenetic modifications, which are reported in various organs, tissues, and cellular compartments. This review discusses the emerging evidence regarding metformin-mediated epigenetic modifications, their significance, potential applications, and future research directions.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Oncology
Riya Su, Xinlin Wu, Liang Tao, Changshan Wang
Summary: Distant metastasis is the main cause of the high mortality rate in colorectal cancer (CRC). Research has found that some epigenetic enzymes are often dysregulated or mutated in multiple tumor types, prompting us to study their roles in CRC metastasis. Existing data suggests that targeting epigenetic enzymes is a promising strategy for treating CRC metastasis.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Review
Dermatology
Chang Zeng, Lam C. Tsoi, Johann E. Gudjonsson
Summary: The incidence of psoriasis is increasing over time, with recent studies pointing towards the importance of epigenetic modifications in its pathogenesis. Aberrant epigenetic patterns, including changes in DNA methylation, histone modifications and non-coding RNA expression, are observed in psoriatic skin. Reversing these epigenetic mechanisms has shown promise in improving psoriatic phenotypes, making epigenetic therapy a potential avenue for treating psoriasis.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Urszula Oleksiewicz, Marta Machnik
Summary: Somatic mutations, transcriptional deregulation, external stimulation, and physiological aging can all contribute to the perturbed epigenomic signature in cancer. These changes are associated with a cell of origin, tumor stage, and differentiation, displaying high heterogeneity.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Genetics & Heredity
Jinkun Xia, Wangsen Cao
Summary: Studies show that epigenetic modifications affect the Klotho gene in renal diseases, impacting disease progression. Lowered Klotho levels worsen the condition, but beneficial changes can be made through epigenetic interventions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Oncology
Veronica Davalos, Manel Esteller
Summary: Cancer development is caused by changes in the structure and function of the genome. Epigenetic alterations regulate gene expression programs that promote tumorigenesis and can be used as useful tools in clinical decision making. Unlike genetic changes, epigenetic modifications can be reversed, making them an attractive target for drug development.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Review
Plant Sciences
Rocio Nunez-Vazquez, Benedicte Desvoyes, Crisanto Gutierrez
Summary: Plants have developed various mechanisms to adapt to abiotic stresses, which involve transcriptional regulation and chromatin modifications. Understanding and manipulating these regulatory networks are crucial for enhancing crop resilience and performance against stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Cell Biology
Wei Li, Hao Wu, Shiyao Sui, Qin Wang, Shouping Xu, Da Pang
Summary: Histone modifications (HMs) play important roles in breast cancer, and their dynamic and reversible processes are closely related to tumorigenesis. However, therapies targeting HMs for breast cancer treatment are still in their infancy, facing barriers to clinical application.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Yuhao Zhao, Mao Yang, Shijia Wang, Sk Jahir Abbas, Junzhe Zhang, Yongsheng Li, Rong Shao, Yingbin Liu
Summary: This review focuses on the mechanistic insights of DNA, histone, and RNA methylation in regulating the progression of pancreatic cancer. The roles of methylation regulators in modulating gene expression associated with cell proliferation, invasion, and apoptosis are discussed. Recent clinical trials on methylation drug targeting are also explored. Understanding the novel regulatory mechanisms of methylation modification may offer alternative opportunities to improve therapeutic efficacy in combating this devastating disease.
FRONTIERS IN ONCOLOGY
(2022)
Review
Endocrinology & Metabolism
Yu Wang, Zhao Huang, Bowen Li, Lin Liu, Canhua Huang
Summary: This article reviews the epigenetic regulation of ovarian cancer drug resistance and highlights the important role of epigenetic modifications, including upregulation of multidrug resistance proteins, remodeling of the tumor microenvironment, and deregulated immune response, in drug resistance of ovarian cancer. A better understanding of these mechanisms may improve outcomes for ovarian cancer patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, Research & Experimental
Ningxin Qu, Ting Luan, Naiquan Liu, Chenhui Kong, Le Xu, Hong Yu, Ye Kang, Ye Han
Summary: HNF4 alpha, a transcription factor, plays a vital role in regulating functional genes and biological processes. Aberrant expression of HNF4 alpha is associated with tumor progression and metastasis, potentially by affecting downstream target genes and signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)