Article
Biochemistry & Molecular Biology
Tian Tian
Summary: In this study, the effects of a new Ag(I)curcuminoid-Gboxin analog complex were investigated using the MCF-7 breast carcinoma cell line. The results showed that Ag(I)FLLL49-GbA could up-regulate the expression of caspase-3, P53, and Bax in MCF-7 cells after 48 hours of treatment. However, it was puzzling because MCF-7 cells do not naturally express caspase-3. Appropriate modifications are suggested to strengthen the findings of this study.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Ola E. E. Abdel-Sattar, Rasha Mosa Allam, Ahmed M. M. Al-Abd, Bharathi Avula, Kumar Katragunta, Ikhlas A. A. Khan, Ahmed M. M. El-Desoky, Shanaz O. O. Mohamed, Ali El-Halawany, Essam Abdel-Sattar, Meselhy R. R. Meselhy
Summary: The genus Phyllanthus has potential in the treatment of various diseases, and its extracts showed cytotoxicity against breast cancer cells. The methylene chloride fraction exhibited the strongest cytotoxic activity among all tested fractions.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Ulyana Munoz Acuna, Nathan Ezzone, L. Harinantenaina Rakotondraibe, Esperanza J. Carcache De Blanco
Summary: Capsicodendrin demonstrated potential anticancer effects in MCF-7 cancer cells by increasing ROS levels to promote caspase-1 activity and induce cell death, suggesting it may be a promising agent for preventing the progression of metastatic breast cancer.
ANTICANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chunjie Ma, Yu Wang, Wei Chen, Ting Hou, Honglian Zhang, Hongguang Zhang, Xu Yao, Chunhui Xia
Summary: This study examined the effects of TaPcZn-PDT on cytotoxicity, cell viability, apoptosis, pyroptosis, cellular reactive oxygen species (ROS), mitochondrial membrane potential (??m), caspase-1, caspase-3, and nuclear transcription factor-?B (NF?B) in MCF-7 cells. The results showed that TaPcZn-PDT increased cytotoxicity and the percentage of apoptotic and pyroptotic cells, decreased cell viability and ??m, induced ROS production, and activated caspase-1, caspase-3, and NF?B in MCF-7 cells. siRNA targeting caspase-1 attenuated the effects of TaPcZn-PDT on apoptosis, pyroptosis, and the activation of caspase-1, caspase-3, and NF?B in MCF-7 cells. Therefore, caspase-1 plays a regulatory role in the apoptosis and pyroptosis induced by TaPcZn-PDT in MCF-7 cells.
Article
Biochemistry & Molecular Biology
Olga A. Sukocheva, Dong Gui Hu, Robyn Meech, Anupam Bishayee
Summary: Breast cancer MCF-7 cell-line-derived mammospheres exhibit enriched CD44+/CD24- cells resembling breast cancer stem cells, expressing high levels of S1P3. Growth-promoting agents induce SphK1 and S1P3 translocation to the nucleus, while TNF alpha inhibits their nuclear translocation and promotes apoptosis in mammospheres. The study suggests inhibiting SphK1 and S1P3 nuclear translocation as a novel approach to prevent BCSC proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Alexander Chota, Blassan P. George, Heidi Abrahamse
Summary: This study investigated the effects of Dicoma anomala methanol root extract on breast cancer cells and found that it decreased cell viability and increased apoptosis. When combined with photodynamic therapy, the effects were more significant.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Organic
Priyotosh Ghosh, Tanmoy Das, Ansuman Chattopadhyay, Prithidipa Sahoo
Summary: In this study, an efficient chemosensor (PCF) based on the pyridine-carbazole moiety was developed for the differential detection of aspartic acid in biological systems. PCF showed strong binding affinity towards aspartic acid, with a nanomolar detection limit. The binding stoichiometry of aspartic acid and PCF was determined to be 1:1 from Jobs plot analysis. Furthermore, the efficacy of PCF was successfully demonstrated in in vitro experiments in MCF-7 breast cancer cells.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Claudio Luparello, Ilenia Cruciata, Andreas C. Joerger, Cory A. Ocasio, Rhiannon Jones, Raysa Khan Tareque, Mark C. Bagley, John Spencer, Martin Walker, Carol Austin, Tiziana Ferrara, Pietro D' Oca, Rossella Bellina, Rossella Branni, Fabio Caradonna
Summary: Carbazole compounds PK9320 and PK9323, as second-generation analogues of PK083, have been shown to restore p53 signaling in cancer cells by binding to mutation-induced surface crevices. The study demonstrates that small modifications in carbazole substitution patterns can significantly impact their genotoxic and epigenetic properties, with PK9320 and PK9323 being potential candidates for anticancer and epi-compounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Ahmed A. Abdelaziz, Amal M. Abo Kamer, Khaled B. Al-Monofy, Lamiaa A. Al-Madboly
Summary: Pyocyanin, a secondary metabolite pigment produced by Pseudomonas aeruginosa, has been shown to exhibit anticancer activity against breast cancer cells through apoptotic and necrotic activities, involving caspase-3 activation.
MICROBIAL CELL FACTORIES
(2022)
Article
Biochemical Research Methods
Tara Jalal, Hatim Abdullah Natto, Ridhwan Abdul Wahab
Summary: This study evaluated the cytotoxicity and toxicological effect of methanol fruit extracts of Artoarpus altilis against MCF-7 cells. The methanol extract of the pulp part showed the strongest inhibition concentration on MCF-7 cells. Furthermore, the methanol extracts induced apoptosis and cell cycle arrest in a time-dependent manner by regulating the expression of apoptosis-related genes, suggesting their potential anticancer activity.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2022)
Article
Multidisciplinary Sciences
Ahreum Kwon, Hyun Wook Chae, Woo Jung Lee, JungHyun Kim, Ye Jin Kim, Jungmin Ahn, Youngman Oh, Ho-Seong Kim
Summary: This study aimed to demonstrate that IGFBP-3 induces cellular senescence and inhibits cell proliferation in MCF-7 breast cancer cells by suppressing telomerase activity. The results showed that IGFBP-3 induction led to loss of cell viability, increased percentage of non-cycling cells, morphological alterations associated with senescence, and decreased telomerase activity. These findings suggest that IGFBP-3 is a negative regulator of MCF-7 breast cancer cell growth through senescence induction and telomerase suppression.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Inorganic & Nuclear
Balaji Babu, John Mack, Tebello Nyokong
Summary: A new Sn(IV) tetraarylchlorin with thien-2-yl substituents (SnC) has been synthesized and characterized, showing high Phi(Delta) value and promising photodynamic activity against MCF-7 breast cancer cells. These results suggest that Sn(IV) tetraarylchlorins like SnC are suitable candidates for further photodynamic therapy studies.
DALTON TRANSACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Carolina Alonso-Gonzalez, Cristina Gonzalez-Abalde, Javier Menendez-Menendez, Alicia Gonzalez-Gonzalez, Virginia Alvarez-Garcia, Alicia Gonzalez-Cabeza, Carlos Martinez-Campa, Samuel Cos
Summary: Radiation therapy is a crucial part of cancer treatment, but it has adverse effects. Melatonin, as an adjuvant molecule, can limit damage to normal tissues and enhance the efficacy of radiation therapy in breast cancer. This study revealed that melatonin can potentiate the anti-proliferative effect of radiation, modulate gene and microRNA expression, and enhance the inhibition of cancer growth. Melatonin shows promise as both a radiosensitizer and radioprotector in breast cancer treatment.
Article
Multidisciplinary Sciences
Judit Doczi, Noemi Karnok, David Bui, Victoria Azarov, Gergely Pallag, Sara Nazarian, Bence Czumbel, Thomas N. N. Seyfried, Christos Chinopoulos
Summary: This study investigates the effects of severe hypoxia, site-specific inhibition of respiratory chain components, and uncouplers on 2D-cultured HepG2 and MCF-7 tumor cells. The results show that there is no correlation between oxidative phosphorylation activity and viability in these cell lines, indicating that the connection between oxidative phosphorylation and cancer cell survival is dependent on cell type and conditions.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Wenqian Yang, Yuan Jiang, Qulian Guo, Zhixin Tian, Zhigang Cheng
Summary: Neu5Gc is an aberrant molecule in humans due to the lack of a converting enzyme. It has been observed in human cancer cells and tissues and can cause obstacles in clinical treatments. Therefore, studying Neu5Gc in humans is important for pathology and clinical relevance.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
