Article
Cell Biology
Mengling Zhang, Hongmei Qiu, Lejiao Mao, Bin Wang, Na Li, Yinzhen Fan, Ping Weng, Siyao Hu, Xiaomei Dong, Xia Qin, Chengzhi Chen, Zhen Zou, Chao Yu, Jun Zhang
Summary: In this study, we discovered that ammonium tetrathiomolybdate (TTM) is a novel NRF2 activator and demonstrated that autophagy contributes to TTM-induced NRF2 activation. We also found that TTM protects cells from oxidative damage through autophagy.
CELL DEATH & DISEASE
(2022)
Review
Chemistry, Inorganic & Nuclear
Biplab K. Maiti, Jose J. G. Moura
Summary: Biological systems rely on proteins to house catalytic metal centers that drive essential assimilation and energy pathways. Imbalance in metal homeostasis, particularly copper overload, can lead to negative consequences like the progression of diseases. Anti-copper therapy, using copper-sequestering drugs like tetrathiomolybdate, shows promise in addressing health issues related to elevated copper levels, such as Wilson disease and cancer.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Cardiac & Cardiovascular Systems
Heng Yu, Hunter F. Douglas, Donald Wathieu, Ryan A. Braun, Christine Edomwande, Daniel J. J. Lightell Jr., Thaidan Pham, Natasha C. Klingenberg, Shelia Pugh Bishop, Damir B. Khismatullin, T. Cooper Woods
Summary: This study found that miR-221/222 transferred via vascular smooth muscle cell-derived exosomes from diabetic sources promote increased intercellular adhesion molecule-1 expression and monocyte adhesion, leading to increased vascular inflammation and atherosclerotic plaque development.
CARDIOVASCULAR DIABETOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yukihito Higashi
Summary: Oxidative stress and chronic inflammation play a crucial role in the development of atherosclerosis, as vascular endothelial dysfunction leads to its progression and forms a vicious cycle with oxidative stress and inflammation.
Article
Immunology
Mirrin J. Dorresteijn, Douwe Dekker, Jelle Zwaag, Suzanne Heemskerk, Hennie M. J. Roelofs, Paul Smits, Johannes G. van der Hoeven, Frank A. D. T. G. Wagener, Peter Pickkers
Summary: Inflammation-induced free radical release is important in the pathogenesis of several diseases. This study investigated the impact of atazanavir-induced hyperbilirubinemia on antioxidant capacity, inflammation, and vascular dysfunction in human experimental endotoxemia. The results showed that hyperbilirubinemia increased antioxidant capacity, attenuated interleukin-10 release, and prevented vascular hyporesponsiveness during systemic inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaoyun Cao, Yalan Wu, Huiling Hong, Xiao Yu Tian
Summary: Atherosclerosis is linked to endothelial dysfunction and vascular inflammation, and SIRT3 and NAD(+) play critical roles in maintaining normal mitochondrial function and improving endothelial function. The deletion of SIRT3 in endothelial cells accelerates atherosclerosis and amplifies vascular inflammation and oxidative stress. Treatment with NAD(+) attenuates these effects. The study also shows that NAD(+) supplementation improves endothelial function and reduces plaque formation in mouse models of atherosclerosis.
Article
Cell Biology
Julian Friebel, Eileen Moritz, Marco Witkowski, Kai Jakobs, Elisabeth Straessler, Andrea Doerner, Daniel Steffens, Marianna Puccini, Stella Lammel, Rainer Glauben, Franziska Nowak, Nicolle Kraenkel, Arash Haghikia, Verena Moos, Heinz-Peter Schutheiss, Stephan B. Felix, Ulf Landmesser, Bernhard H. Rauch, Ursula Rauch
Summary: The study found that vorapaxar may reduce inflammation in atherosclerosis by inhibiting the PAR1 signaling pathway, potentially helping to lower the risk of thrombo-inflammatory events in patients.
Review
Peripheral Vascular Disease
Fabrizio Buffolo, Silvia Monticone, Giovanni Camussi, Elena Aikawa
Summary: Extracellular vesicles (EVs) are membrane-bound structures released by cells that play a pathological role in vascular damage. They facilitate cell-to-cell communication by transferring nucleic acids, protein cargos, and metabolites. EVs promote endothelial dysfunction, vascular inflammation, and contribute to plaque formation and vascular calcification.
Article
Health Care Sciences & Services
Rafael Ramirez, Noemi Ceprian, Andrea Figuer, Gemma Valera, Guillermo Bodega, Matilde Alique, Julia Carracedo
Summary: Atherosclerosis is closely linked to aging, with cellular senescence, oxidative stress, and inflammation playing key roles in its pathophysiology. Elevated oxidative stress leads to cellular senescence and a shift to a senescent secretory phenotype, activating immune cells and causing chronic systemic inflammation. Identifying senescent cell biomarkers and developing therapies against senescent cells have become important in combating atherosclerosis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Dianne Vreeken, Caroline Suzanne Bruikman, Wendy Stam, Stefan Martinus Leonardus Cox, Zsofia Nagy, Huayu Zhang, Rudmer Johannes Postma, Anton Jan van Zonneveld, Gerard Kornelis Hovingh, Janine Maria van Gils
Summary: The study demonstrates differential expression of NGCs in endothelial cells and monocytes under pro-inflammatory conditions, with reduced expression of endothelial PLXNA4. PLXNA4 plays a crucial role in maintaining endothelial barrier function, preventing vascular leakage of fluids and cells.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Min Ji Cho, Dong Gwang Lee, Jeong Woong Lee, Byungtae Hwang, Sung-Jin Yoon, Seon-Jin Lee, Young-Jun Park, Seung-Ho Park, Hee Gu Lee, Yong-Hoon Kim, Chul-Ho Lee, Jangwook Lee, Nam-Kyung Lee, Tae-Su Han, Hyun-Soo Cho, Jeong Hee Moon, Ga Seul Lee, Kwang-Hee Bae, Geum-Sook Hwang, Sang-Hak Lee, Sang J. Chung, Sungbo Shim, Jaehyung Cho, Goo Taeg Oh, Young-Guen Kwon, Jong-Gil Park, Jeong-Ki Min
Summary: This study investigates the role of protein tyrosine phosphatase type IVA1 (PTP4A1) in the negative regulation of the NF-kappa B signalling pathway in endothelial cells (ECs). The findings suggest that PTP4A1 regulates NF-kappa B inactivation through the USF1/A20 axis, and its expression or activation in ECs may be useful for the treatment of vascular inflammatory diseases.
CARDIOVASCULAR RESEARCH
(2023)
Review
Immunology
Jiaojiao Xue, Ziwei Zhang, Yuting Sun, Di Jin, Liming Guo, Xiangyan Li, Daqing Zhao, Xiaochun Feng, Wenxiu Qi, Haoyu Zhu
Summary: Endothelial cells (ECs) serve crucial functions in the vascular system by regulating tension, hemostasis, and thrombosis. Dysregulated inflammation can lead to various vascular disorders, and ECs play a critical role in the genesis and progression of vascular inflammation. This review aims to provide a comprehensive understanding of ECs' contributions to inflammation, molecular signaling pathways involved, and treatment strategies for vascular-related diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shiyao Xie, Enyong Su, Xiaoyue Song, Junqiang Xue, Peng Yu, Baoli Zhang, Ming Liu, Hong Jiang
Summary: This study reveals the essential role of GSDME in endothelial cell inflammation and atherogenesis, highlighting its impact on mitochondrial damage and the STING pathway as potential therapeutic targets for vascular pathologies.
Review
Biochemistry & Molecular Biology
Lan-Lan Bu, Huan-Huan Yuan, Ling-Li Xie, Min-Hua Guo, Duan-Fang Liao, Xi-Long Zheng
Summary: This review examines the molecular mechanisms and functional alterations associated with endothelial cell senescence and death in different stages of atherosclerosis, highlighting the various factors and forms of cell death involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Xuesong Li, Xiang Chen, Longbin Zheng, Minghong Chen, Yunjia Zhang, Ruigong Zhu, Jiajing Chen, Jiaming Gu, Quanwen Yin, Hong Jiang, Xuan Wu, Xian Ji, Xin Tang, Mengdie Dong, Qingguo Li, Yuanqing Gao, Hongshan Chen
Summary: This study reveals the activation of the non-canonical STING-PERK pathway in atherosclerosis, which increases BRD4 expression and promotes the transactivation of proinflammatory cytokines. This pathway is triggered by leaked mitochondrial DNA via interaction with oxidized mtDNA. Endothelial STING activation plays a significant role in atherosclerosis.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Hao Wei, Elizabeth J. Tarling, Timothy S. McMillen, Chongren Tang, Renee C. LeBoeuf
JOURNAL OF LIPID RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
Chongren Tang, Yuhua Liu, Wendy Yang, Carl Storey, Tim S. McMillen, Barbara A. Houston, Jay W. Heinecke, Renee C. LeBoeuf
JOURNAL OF LIPID RESEARCH
(2016)
Article
Endocrinology & Metabolism
Nathalie Pamir, Timothy S. McMillen, Kimberly A. Edgel, Francis Kim, Renee C. LeBoeuf
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2012)
Article
Biochemistry & Molecular Biology
Kimberly A. Edgel, Timothy S. McMillen, Hao Wei, Nathalie Pamir, Barbara A. Houston, Mark T. Caldwell, Phuong-Oanh T. Mai, John F. Oram, Chongren Tang, Renee C. LeBoeuf
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2012)
Article
Cardiac & Cardiovascular Systems
Tomio Umemoto, Chang Yeop Han, Poulami Mitra, Michelle M. Averill, Chongren Tang, Leela Goodspeed, Mohamed Omer, Savitha Subramanian, Shari Wang, Laura J. Den Hartigh, Hao Wei, Eung Ju Kim, Jinkyu Kim, Kevin D. O'Brien, Alan Chait
CIRCULATION RESEARCH
(2013)
Article
Biochemistry & Molecular Biology
Sabrina H. Spiezio, Lynn M. Amon, Timothy S. McMillen, Cynthia M. Vick, Barbara A. Houston, Mark Caldwell, Kayoko Ogimoto, Gregory J. Morton, Elizabeth A. Kirk, Michael W. Schwartz, Joseph H. Nadeau, Renee C. LeBoeuf
Article
Multidisciplinary Sciences
Shams Kursan, Timothy S. McMillen, Pavani Beesetty, Eduardo Dias-Junior, Mohammed M. Almutairi, Abu A. Sajib, J. Ashot Kozak, Lydia Aguilar-Bryan, Mauricio Di Fulvio
SCIENTIFIC REPORTS
(2017)
Article
Endocrinology & Metabolism
T. S. McMillen, E. Minami, R. C. LeBoeuf
NUTRITION & DIABETES
(2013)
Article
Endocrinology & Metabolism
H. Wei, M. M. Averill, T. S. McMillen, F. Dastvan, P. Mitra, S. Subramanian, C. Tang, A. Chait, R. C. LeBoeuf
NUTRITION & DIABETES
(2014)
Article
Biochemistry & Molecular Biology
Jelena Sikimic, Timothy S. McMillen, Cita Bleile, Frank Dastvan, Ulrich Quast, Peter Krippeit-Drews, Gisela Drews, Joseph Bryan
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Medicine, Research & Experimental
Nathalie Pamir, Patrick M. Hutchins, Graziella E. Ronsein, Hao Wei, Chongren Tang, Riku Das, Tomas Vaisar, Edward Plow, Volker Schuster, Catherine A. Reardon, Richard Weinberg, David A. Dichek, Santica Marcovina, Godfrey S. Getz, Jay W. Heinecke
Article
Physiology
Xiuju Wu, Richard C. Davis, Timothy S. McMillen, Valerie Schaeffer, Zhiqiang Zhou, Hongxiu Qi, Parisa N. Mazandarani, Roshanak Alialy, Kelly L. Hudkins, Aldons J. Lusis, Renee C. LeBoeuf
PHYSIOLOGICAL REPORTS
(2014)