Pleiotropic Effects of the Protease-Activated Receptor 1 (PAR1) Inhibitor, Vorapaxar, on Atherosclerosis and Vascular Inflammation
出版年份 2021 全文链接
标题
Pleiotropic Effects of the Protease-Activated Receptor 1 (PAR1) Inhibitor, Vorapaxar, on Atherosclerosis and Vascular Inflammation
作者
关键词
-
出版物
Cells
Volume 10, Issue 12, Pages 3517
出版商
MDPI AG
发表日期
2021-12-14
DOI
10.3390/cells10123517
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Plasminogen‐induced foam cell formation by macrophages occurs through a Histone 2B (H2B)‐PAR1 pathway and requires integrity of clathrin‐coated pits
- (2021) Lahoucine Izem et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Single-Cell Transcriptomic Atlas of Different Human Cardiac Arteries Identifies Cell Types Associated With Vascular Physiology
- (2021) Zhan Hu et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Inflammation during the life cycle of the atherosclerotic plaque
- (2021) Peter Libby CARDIOVASCULAR RESEARCH
- Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis
- (2021) Marco Witkowski et al. CARDIOVASCULAR RESEARCH
- Antithrombotic therapies in aortic and peripheral arterial diseases in 2021: a consensus document from the ESC working group on aorta and peripheral vascular diseases, the ESC working group on thrombosis, and the ESC working group on cardiovascular pharmacotherapy
- (2021) Victor Aboyans et al. EUROPEAN HEART JOURNAL
- 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
- (2021) Frank L J Visseren et al. European Journal of Preventive Cardiology
- Vascular miR-181b controls tissue factor-dependent thrombogenicity and inflammation in type 2 diabetes
- (2020) Marco Witkowski et al. Cardiovascular Diabetology
- Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel
- (2020) Jan Borén et al. EUROPEAN HEART JOURNAL
- Thrombin Promotes Macrophage Polarization into M1-Like Phenotype to Induce Inflammatory Responses
- (2020) Mercedes López-Zambrano et al. THROMBOSIS AND HAEMOSTASIS
- Vulnerable plaques and patients: state-of-the-art
- (2020) Mariusz Tomaniak et al. EUROPEAN HEART JOURNAL
- Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis
- (2020) Elisa d’Alessandro et al. THROMBOSIS AND HAEMOSTASIS
- Tissue factor in atherosclerosis and atherothrombosis
- (2020) Steven P. Grover et al. ATHEROSCLEROSIS
- Proteinase‐activated receptor 1: A target for repurposing in the treatment of COVID‐19?
- (2020) Krishna Sriram et al. BRITISH JOURNAL OF PHARMACOLOGY
- Gut Microbiota and Cardiovascular Disease
- (2020) Marco Witkowski et al. CIRCULATION RESEARCH
- Factor Xa and thrombin induce endothelial progenitor cell activation. The effect of direct oral anticoagulants
- (2020) Styliani Papadaki et al. PLATELETS
- Dual Pathway Inhibition for Vascular Protection in Patients with Atherosclerotic Disease: Rationale and Review of the Evidence
- (2020) Jeffrey Ian Weitz et al. THROMBOSIS AND HAEMOSTASIS
- Pleiotropic actions of factor Xa inhibition in cardiovascular prevention - mechanistic insights and implications for anti-thrombotic treatment
- (2020) Hugo ten Cate et al. CARDIOVASCULAR RESEARCH
- Thrombin-Par1 signaling axis disrupts COP9 signalosome subunit 3-mediated ABCA1 stabilization in inducing foam cell formation and atherogenesis
- (2020) Monoranjan Boro et al. CELL DEATH AND DIFFERENTIATION
- Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics
- (2020) Marie AC Depuydt et al. CIRCULATION RESEARCH
- Differential immunological signature at the culprit site distinguishes acute coronary syndrome with intact from acute coronary syndrome with ruptured fibrous cap: results from the prospective translational OPTICO-ACS study
- (2020) David M Leistner et al. EUROPEAN HEART JOURNAL
- Atherosclerotic Plaque Healing
- (2020) Rocco Vergallo et al. NEW ENGLAND JOURNAL OF MEDICINE
- Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge–Mediated Monocyte Adhesion
- (2020) Ariane Schumski et al. CIRCULATION
- Reassessing the Mechanisms of Acute Coronary Syndromes
- (2019) Peter Libby et al. CIRCULATION RESEARCH
- Understanding and preventing atherosclerosis: from bench to bedside
- (2019) Thomas F Lüscher EUROPEAN HEART JOURNAL
- Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction
- (2019) Julian Friebel et al. EUROPEAN HEART JOURNAL
- Vorapaxar stabilizes permeability of the endothelial barrier under cholesterol stimulation via the AKT/JNK and NF‑κB signaling pathways
- (2019) Jianliang Pang et al. Molecular Medicine Reports
- Targeting coagulation in heart failure with preserved ejection fraction and cardiac fibrosis
- (2019) Christoph Hofmann et al. EUROPEAN HEART JOURNAL
- 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes
- (2019) Juhani Knuuti et al. EUROPEAN HEART JOURNAL
- Molecular basis of protease‐activated receptor 1 signalling diversity
- (2019) Orla Willis‐Fox et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Low-grade endotoxaemia enhances artery thrombus growth via Toll-like receptor 4: implication for myocardial infarction
- (2019) Roberto Carnevale et al. EUROPEAN HEART JOURNAL
- PAR2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis in MiceHighlights
- (2018) Shannon M. Jones et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Noncanonical Matrix Metalloprotease 1–Protease-Activated Receptor 1 Signaling Drives Progression of AtherosclerosisHighlights
- (2018) Rajashree Rana et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Proteases, Protease-Activated Receptors, and Atherosclerosis
- (2018) Wolfram Ruf ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- PKCθ via Activating Transcription Factor 2-Mediated CD36 Expression and Foam Cell Formation of Ly6ChiCells Contributes to Atherosclerosis
- (2018) Somasundaram Raghavan et al. CIRCULATION
- Protease-activated receptor 1 inhibits cholesterol efflux and promotes atherogenesis via cullin 3–mediated degradation of the ABCA1 transporter
- (2018) Somasundaram Raghavan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pleiotropic effects of the hemostatic system
- (2018) B. M. M. Kremers et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Release of Platelet-Derived Sphingosine-1-Phosphate Involves Multidrug Resistance Protein 4 (MRP4/ABCC4) and Is Inhibited by Statins
- (2018) Katja Vogt et al. THROMBOSIS AND HAEMOSTASIS
- Inhibition of Protease-Activated Receptor (PAR1) Reduces Activation of the Endothelium, Coagulation, Fibrinolysis and Inflammation during Human Endotoxemia
- (2018) Christian Schoergenhofer et al. THROMBOSIS AND HAEMOSTASIS
- Immune system-mediated atherosclerosis caused by deficiency of long non-coding RNA MALAT1 in ApoE−/−mice
- (2018) Martina Gast et al. CARDIOVASCULAR RESEARCH
- Roles of Coagulation Proteases and PARs (Protease-Activated Receptors) in Mouse Models of Inflammatory Diseases
- (2018) Jens J. Posma et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- TAK-442, a Direct Factor Xa Inhibitor, Inhibits Monocyte Chemoattractant Protein 1 Production in Endothelial Cells via Involvement of Protease-Activated Receptor 1
- (2018) Emiko Shinozawa et al. Frontiers in Pharmacology
- Role for Thrombin Receptor Antagonism With Vorapaxar in Secondary Prevention of Atherothrombotic Events: From Bench to Bedside
- (2017) Jae Youn Moon et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
- Targeting PAR1: Now What?
- (2017) Robert Flaumenhaft et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Apolipoprotein E Receptor 2 Mediates Activated Protein C–Induced Endothelial Akt Activation and Endothelial Barrier StabilizationSignificance
- (2016) Ranjeet K. Sinha et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Micro–RNA-126 Reduces the Blood Thrombogenicity in Diabetes Mellitus via Targeting of Tissue FactorHighlights
- (2016) Marco Witkowski et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- The Role of Protease-Activated Receptors for the Development of Myocarditis: Possible Therapeutic Implications
- (2016) Alice Weithauser et al. CURRENT PHARMACEUTICAL DESIGN
- Coagulation and non-coagulation effects of thrombin
- (2016) J. J. N. Posma et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Humanizing the Protease-Activated Receptor (PAR) Expression Profile in Mouse Platelets by Knocking PAR1 into the Par3 Locus Reveals PAR1 Expression Is Not Tolerated in Mouse Platelets
- (2016) Shauna L. French et al. PLoS One
- Treating the Unstable Atherosclerotic Plaque by Targeting Activated Factor X – Anticoagulation and Beyond –
- (2015) Julian Friebel et al. CIRCULATION JOURNAL
- Atherosclerosis, neoatherosclerosis, and vascular disease
- (2015) Thomas F. Lüscher EUROPEAN HEART JOURNAL
- “Soluble Tissue Factor” in the 21st Century: Definitions, Biochemistry, and Pathophysiological Role in Thrombus Formation
- (2015) Henri Versteeg et al. SEMINARS IN THROMBOSIS AND HEMOSTASIS
- Anti-inflammatory therapies for cardiovascular disease
- (2014) P. M. Ridker et al. EUROPEAN HEART JOURNAL
- Thrombin selectively induces transcription of genes in human monocytes involved in inflammation and wound healing
- (2014) Gustavo Bruges et al. THROMBOSIS AND HAEMOSTASIS
- Role of protease-activated receptors for the innate immune response of the heart
- (2014) Alice Weithauser et al. TRENDS IN CARDIOVASCULAR MEDICINE
- Proteinase-activated receptors (PARs) – focus on receptor-receptor-interactions and their physiological and pathophysiological impact
- (2013) Frank Gieseler et al. Cell Communication and Signaling
- PAR-1 contributes to the innate immune response during viral infection
- (2013) Silvio Antoniak et al. JOURNAL OF CLINICAL INVESTIGATION
- Protease-Activated Receptor-2 Regulates the Innate Immune Response to Viral Infection in a Coxsackievirus B3–Induced Myocarditis
- (2013) Alice Weithauser et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Enhanced Effector Function of CD8+ T Cells From Healthy Controls and HIV-Infected Patients Occurs Through Thrombin Activation of Protease-Activated Receptor 1
- (2012) Amanda Hurley et al. JOURNAL OF INFECTIOUS DISEASES
- Human Atherosclerotic Plaque Alternative Macrophages Display Low Cholesterol Handling but High Phagocytosis Because of Distinct Activities of the PPARγ and LXRα Pathways
- (2011) Giulia Chinetti-Gbaguidi et al. CIRCULATION RESEARCH
- Splice variants of tissue factor promote monocyte-endothelial interactions by triggering the expression of cell adhesion molecules via integrin-mediated signaling
- (2011) R. SRINIVASAN et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through -arrestin and dishevelled-2 scaffolds
- (2011) U. J. K. Soh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Early Atherosclerosis Exhibits an Enhanced Procoagulant State
- (2010) Julian Ilcheff Borissoff et al. CIRCULATION
- Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality
- (2009) F. Niessen et al. BLOOD
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