Efflux pump inhibitors: targeting mycobacterial efflux systems to enhance TB therapy

The Efflux Pump Inhibitor Timcodar Improves the Potency of Antimycobacterial Agents

(2014) Trudy H. Grossman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis of new verapamil analogues and their evaluation in combination with rifampicin against Mycobacterium tuberculosis and molecular docking studies in the binding site of efflux protein Rv1258c

(2014) Kawaljit Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Verapamil, and Its Metabolite Norverapamil, Inhibit Macrophage-induced, Bacterial Efflux Pump-mediated Tolerance to Multiple Anti-tubercular Drugs

(2014) Kristin N. Adams et al.   JOURNAL OF INFECTIOUS DISEASES

Bedaquiline: A novel antitubercular drug for multidrug-resistant tuberculosis

(2014) H Nagabushan et al.   Journal of Postgraduate Medicine

Ofloxacin Resistance in Mycobacterium tuberculosis Is Associated with Efflux Pump Activity Independent of Resistance Pattern and Genotype

(2014) Zhaogang Sun et al.   Microbial Drug Resistance

Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline

(2014) Andreas H. Diacon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acquired Resistance of Mycobacterium tuberculosis to Bedaquiline

(2014) Koen Andries et al.   PLoS One

Protective efficacy of piperine against Mycobacterium tuberculosis

(2014) Sandeep Sharma et al.   TUBERCULOSIS

Efflux pumps of Gram-negative bacteria: what they do, how they do it, with what and how to deal with them

(2014) Leonard Amaral et al.   Frontiers in Pharmacology

Acceleration of Tuberculosis Treatment by Adjunctive Therapy with Verapamil as an Efflux Inhibitor

(2013) Shashank Gupta et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Efflux Inhibition with Verapamil Potentiates Bedaquiline in Mycobacterium tuberculosis

(2013) Shashank Gupta et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The crystal structure of multidrug-resistance regulator RamR with multiple drugs

(2013) Suguru Yamasaki et al.   Nature Communications

Sterilizing Activities of Novel Combinations Lacking First- and Second-Line Drugs in a Murine Model of Tuberculosis

(2012) Kathy Williams et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efflux Pumps of Mycobacterium tuberculosis Play a Significant Role in Antituberculosis Activity of Potential Drug Candidates

(2012) Meenakshi Balganesh et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Antibiotic Resistance Arrow of Time: Efflux Pump Induction Is a General First Step in the Evolution of Mycobacterial Drug Resistance

(2012) Aurelia M. Schmalstieg et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of the Mmr Efflux Pump in Drug Resistance in Mycobacterium tuberculosis

(2012) L. Rodrigues et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibitors of mycobacterial efflux pumps as potential boosters for anti-tubercular drugs

(2012) Miguel Viveiros et al.   Expert Review of Anti-Infective Therapy

Contribution of Efflux to the Emergence of Isoniazid and Multidrug Resistance in Mycobacterium tuberculosis

(2012) Diana Machado et al.   PLoS One

Rifampicin Reduces Susceptibility to Ofloxacin in Rifampicin-resistantMycobacterium tuberculosisthrough Efflux

(2011) Gail E. Louw et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism

(2011) Kristin N. Adams et al.   CELL

Contribution of efflux activity to isoniazid resistance in the Mycobacterium tuberculosis complex

(2011) Liliana Rodrigues et al.   INFECTION GENETICS AND EVOLUTION

Piperine as an inhibitor of Rv1258c, a putative multidrug efflux pump of Mycobacterium tuberculosis

(2010) S. Sharma et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The plant alkaloid piperine as a potential inhibitor of ethidium bromide efflux in Mycobacterium smegmatis

(2010) J. Jin et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: Binding aspects and implications for drug design

(2010) Kakali Bhadra et al.   MEDICINAL RESEARCH REVIEWS

Farnesol, a Potential Efflux Pump Inhibitor in Mycobacterium smegmatis

(2010) Jing Jin et al.   MOLECULES

Role of the Mycobacterium tuberculosis P55 Efflux Pump in Intrinsic Drug Resistance, Oxidative Stress Responses, and Growth

(2009) S. Ramon-Garcia et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Drug transport mechanism of the AcrB efflux pump

(2009) Klaas M. Pos   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The role of efflux pumps in macrolide resistance in Mycobacterium avium complex

(2009) Liliana Rodrigues et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis

(2009) Andreas H. Diacon et al.   NEW ENGLAND JOURNAL OF MEDICINE

The alkaloid Berberine inhibits the growth of Anoikis-resistant MCF-7 and MDA-MB-231 breast cancer cell lines by inducing cell cycle arrest

(2009) J.B. Kim et al.   PHYTOMEDICINE

pH Modulation of Efflux Pump Activity of Multi-Drug Resistant Escherichia coli: Protection During Its Passage and Eventual Colonization of the Colon

(2009) Ana Martins et al.   PLoS One

Citral derived amides as potent bacterial NorA efflux pump inhibitors

(2008) Niranjan Thota et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The AcrB Efflux Pump: Conformational Cycling and Peristalsis Lead to Multidrug Resistance

(2008) Markus Seeger et al.   CURRENT DRUG TARGETS

Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis

(2008) L. Rodrigues et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Diarylquinolines Are Bactericidal for Dormant Mycobacteria as a Result of Disturbed ATP Homeostasis

(2008) Anil Koul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5–MmpL5 efflux system

(2008) Anna Milano et al.   TUBERCULOSIS