CYP3A4 activity reduces the cytotoxic effects of okadaic acid in HepaRG cells

The structures of three metabolites of the algal hepatotoxin okadaic acid produced by oxidation with human cytochrome P450

(2012) Li Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

(2012) H. H. J. Gerets et al.   CELL BIOLOGY AND TOXICOLOGY

Development of a Rapid LC-UV Method for the Investigation of Chemical and Metabolic Stability of Resveratrol Oligomers

(2012) Ina Willenberg et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Study of possible combined toxic effects of azaspiracid-1 and okadaic acid in mice via the oral route

(2012) Tore Aune et al.   TOXICON

Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism

(2011) Jie Lin et al.   ARCHIVES OF TOXICOLOGY

Inhibitory effects of ketoconazole and rifampin on OAT1 and OATP1B1 transport activities: considerations on drug-drug interactions

(2011) Min-Koo Choi et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Okadaic acid induces morphological changes, apoptosis and cell cycle alterations in different human cell types

(2011) Vanessa Valdiglesias et al.   JOURNAL OF ENVIRONMENTAL MONITORING

Activation of a tunicate (Ciona intestinalis) xenobiotic receptor orthologue by both natural toxins and synthetic toxicants

(2011) Andrew E. Fidler et al.   TOXICON

Identification Strategy Using Combined Mass Spectrometric Techniques for Elucidation of Phase I and Phase II in Vitro Metabolites of Lipophilic Marine Biotoxins

(2010) Katrin Kittler et al.   ANALYTICAL CHEMISTRY

Analysis of the passage of the marine biotoxin okadaic acid through an in vitro human gut barrier

(2010) Anke Ehlers et al.   TOXICOLOGY

Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells

(2009) S. Antherieu et al.   DRUG METABOLISM AND DISPOSITION

Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies

(2008) K. P. Kanebratt et al.   DRUG METABOLISM AND DISPOSITION

CYP1A1 induction and CYP3A4 inhibition by the fungicide imazalil in the human intestinal Caco-2 cells—Comparison with other conazole pesticides

(2008) Thérèse Sergent et al.   TOXICOLOGY LETTERS