Article
Mechanics
M. Kalli, P. Pico, L. Chagot, L. Kahouadji, S. Shin, J. Chergui, D. Juric, O. K. Matar, P. Angeli
Summary: The effect of surfactants on flow characteristics during rapid drop formation in a microchannel was investigated using various techniques. Results showed strong circulation patterns in the forming drop in the absence of surfactants, which decreased with increasing surfactant concentration. The study also observed the surfactant concentration profiles at different stages of drop formation and the impact of Marangoni stresses on the velocity profile inside the drop.
JOURNAL OF FLUID MECHANICS
(2023)
Article
Mechanics
Piyush Singh, Narinder Singh, Anikesh Pal
Summary: The impact of a heavier droplet falling into a deep pool of lighter liquid is investigated using three-dimensional numerical simulations. It is demonstrated that the heavier droplets can hang from the surface of a lighter liquid using surface tension. The research explores the impact phenomenon, the evolution of the droplet, and formulates a theoretical model to understand the energy associated with the hanging droplet. Analytical solutions for the force balance equations of the hanging droplets are obtained and match well with simulation results. This research has implications in various fields such as drug and gene delivery, biomolecule encapsulation, microfluidics, soft robots, and oil spill remediation.
JOURNAL OF FLUID MECHANICS
(2023)
Article
Multidisciplinary Sciences
Johannes Hartmann, Maximilian T. Schuer, Steffen Hardt
Summary: The authors demonstrate a method for controlling droplet coalescence by inducing dipoles inside droplets using an external electric field. The repulsive dipole force efficiently suppresses droplet coalescence on a liquid-infused surface, allowing for the manipulation and control of droplets. These findings reveal the dependence of the repulsion force on droplet volumes, distance between droplets, and electric field strength.
NATURE COMMUNICATIONS
(2022)
Article
Mechanics
Dege Li, Haoren Li, Guodong Yang, Yi Cao, Bingfang Huang, Xinlei Wu, Qiang Sun, Chi Ma, Yu Zhou, Yonghong Liu, Yanzhen Zhang
Summary: This study proposes a confined interface vibration inkjet printing technique that allows for printing patterns in a liquid environment with smaller droplet sizes. By adjusting the intensity of the pulse stimulation, the size and quantity of the dispensed droplets can be controlled, enriching the fundamental theory of inkjet printing in liquid phase.
JOURNAL OF FLUID MECHANICS
(2022)
Article
Mechanics
Hongyu Zhao, Daniel Orejon, Khellil Sefiane, Martin E. R. Shanahan
Summary: This study investigates the spontaneous motion of liquid droplets on hydrophobic, micro-structured, solid surfaces with a structural gradient. The research explains the observations by considering variable droplet-surface interactions and incorporates the oscillatory motion of the droplet into the modeling. The results show good agreement between the theoretical model and experiments, highlighting the importance of vertical oscillation in overcoming wetting hysteresis and actuating motion.
JOURNAL OF FLUID MECHANICS
(2021)
Article
Mechanics
Jia Ming Zhang, Yibo Chen, Detlef Lohse, Alvaro Marin
Summary: The research shows that water droplets can vanish in sparsely miscible liquid media under certain conditions and the dissolution of water microdroplets in oil in microchannels is influenced by the permeability of the walls. Experimental measurements and simulations are consistent when considering the boundary conditions of the confined system, neighboring droplets, and the evaporative water vapor flux through the permeable walls.
JOURNAL OF FLUID MECHANICS
(2021)
Article
Chemistry, Multidisciplinary
Mayssam Naji, Ecem Yelekli Kirici, Ali Javili, E. Yegan Erdem
Summary: The motion of a droplet on a textured ratchet track was studied using a nonlinear resonator model and a double pendulum as a basis for modeling the asymmetric force. By highlighting the similarities between droplet motion and resonators, a method utilizing an inverted double pendulum to simulate droplet motion was proposed. This approach aims to develop an accurate droplet-motion modeling approach and deepen the understanding of droplet dynamics.
Article
Chemistry, Analytical
Yao Chen, Lin Jiang, Xiaozhe Zhang, Zhonghua Ni, Nan Xiang
Summary: This article introduces an efficient label-free sorting and mechanical phenotyping method for tumor cells, which utilizes a viscoelastic-sorting integrated deformability cytometer (VSDC) to sort, extract, and analyze the mechanical properties of tumor cells. Machine learning algorithms are used to distinguish tumor cells from white blood cells.
ANALYTICAL CHEMISTRY
(2023)
Article
Mechanics
M. Lopez, M. G. Cabezas, J. M. Montanero, M. A. Herrada
Summary: In this study, the stability of hydrodynamic focusing to produce microemulsions is investigated experimentally and numerically. It is found that the distance between the feeding capillary and the focusing orifice affects the liquid ejection stability. Confined selective withdrawal enhances the stability of the microdripping mode. Surfactants stabilize the meniscus and promote the transition from microdripping to jetting. The global stability analysis accurately predicts the critical flow rate ratio and the droplet emission frequency.
JOURNAL OF FLUID MECHANICS
(2022)
Article
Microbiology
Emma Kate Loveday, Humberto S. Sanchez, Mallory M. Thomas, Connie B. Chang
Summary: Drop-based microfluidics is a cutting-edge tool in single-cell research. Here, we used drop-based microfluidics to encapsulate thousands of individual cells infected with influenza A virus within picoliter-sized drops. Similar levels of viral progeny as determined by RT-qPCR and plaque assay were observed from encapsulated cells in drops compared to bulk culture. This approach enables the ability to propagate influenza A virus from encapsulated cells, allowing for future high-throughput analysis of single host cell interactions in isolated microenvironments over the course of the viral life cycle.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Multidisciplinary
Ye Hun Choi, Ji-Su Hwang, Sang Hoon Han, Chang-Soo Lee, Seog-Jin Jeon, Shin-Hyun Kim
Summary: The study introduces microcapsules with thermo- and photo-responsive capabilities, allowing for control over volume changes and cut-off threshold by adjusting temperature and near-infrared irradiation. Temperature control enables molecule-selective encapsulation and controlled release, making the microcapsules suitable for drug carriers, microreactors, and microsensors.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Analytical
Navya Rastogi, Pranjal Seth, Ramray Bhat, Prosenjit Sen
Summary: The novel orthogonal vortex chip enables size-based cell separation at lower velocities to avoid cell damage caused by high flow speeds. The device utilizes shear-gradient lift, centrifugal, and Dean flow drag forces to selectively trap particles of different sizes, showing promising results for gentle isolation of rare cells from blood.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Li Wu, Shihan Xu, Jingang Wang, Amy L. Paguirigan, Jerald P. Radich, Yuling Qin, Daniel T. Chiu
Summary: Researchers have developed a single cell dispenser inspired by electrohydrodynamic jet printing, which can be used for single-cell multiomics studies, achieving accurate droplet generation and single-cell dispensing through systematic parameter optimization.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Zhenna Chen, Beibei Chen, Man He, Bin Hu
Summary: A negative magnetophoresis focusing microchip was developed and coupled to ICP-MS for single-cell analysis, achieving high sample throughput. Study on uptake behaviors revealed that MCF-7 cells exhibited more remarkable heterogeneity when treated with ZnO NPs, with lower uptake content compared to Zn2+.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Chemical
Haotian Cha, Hoseyn A. Amiri, Sima Moshafi, Ali Karimi, Ali Nikkhah, Xiangxun Chen, Hang T. Ta, Nam-Trung Nguyen, Jun Zhang
Summary: Inertial microfluidics is a technique that uses the finite inertia of fluid at high flow speed to manipulate and separate microparticles. Embedding periodic micro-obstacles into curvilinear channels has been found to be an effective strategy to improve inertial focusing and separation. This study systematically investigated the influence of micro-obstacles on inertial focusing and developed a high-resolution microfluidic device for particle and cell separation. The results showed that concave obstacles were more effective in tuning particle inertial focusing and separation compared to convex obstacles, and the square concave obstacle channel offered the highest separation resolution. The developed microfluidic device showed high-efficiency separation of polystyrene beads and U87MG cancer cells from blood.
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Chemistry, Analytical
Zheng Ao, Hongwei Cai, Zhuhao Wu, Jonathan Krzesniak, Chunhui Tian, Yvonne Y. Lai, Ken Mackie, Feng Guo
Summary: The study introduces a human spinal organoid-on-a-chip device for modeling the biology and electrophysiology of human nociceptive neurons and dorsal horn interneurons. The device allows for testing nociceptive modulators and is cost-efficient, scalable, and easy to use. By integrating human sensory-spinal-cord organoids, the method shows promise for screening and validating novel therapeutics for human pain medicine discovery.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Bei Chen, Ganggang Wang, Chunyu Huang, Yue Sun, Jing Zhang, Zhuomin Chai, Shi-Shang Guo, Xing-Zhong Zhao, Yufeng Yuan, Wei Liu
Summary: Isolation of circulating tumor cells (CTCs) from patients is challenging due to their rarity. In this study, a method combining nanostructures with a photocurable hydrogel (CSMA) was presented for single-cell recovery. The gelatin nanoparticles (Gnps) were synthesized and modified on a flat glass substrate for specific capture of CTCs. Selected cells were encapsulated with CSMA using a 405 nm laser, while unselected cells were removed. The isolated CTCs were analyzed using nucleic acid detection, and the results demonstrated the platform's biocompatibility and successful isolation of selected cells. This light-induced hydrogel responsive platform holds potential for clinical applications.
Article
Materials Science, Biomaterials
Hui Chen, Liang Du, Juan Li, Zhuhao Wu, Zhiyi Gong, Yu Xia, Zhou Fan, Qun Qian, Zhao Ding, Hang Hu, Shishang Guo
Summary: Acoustic bioprinting technology can be used to construct tumor microtissues for modeling cancer invasion and has the potential in personalized treatment.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Physical
Yuanzheng Zhang, Xiangyang Gao, Yunchen Zhang, Jinzheng Gui, Chengliang Sun, Haiwu Zheng, Shishang Guo
Summary: This study presents a high-efficiency SCPS composed of R-HNG and ASC, which demonstrate superior charging performance and energy storage capacity. Enhancement of the R-TENG output characteristics is achieved by adjusting the work function difference between the friction layer and electrode. The SCPS can reach 5.9 V in 120 s at a rotation speed of 200 rpm, making it suitable for powering outdoor search and rescue positioning devices.
Article
Chemistry, Multidisciplinary
Xiangyang Gao, Yuanzheng Zhang, Shukun Yin, Yiqian Mao, Jinzheng Gui, Jingxing Li, Yafei Zhao, Chengliang Sun, Shishang Guo
Summary: This study presents a high-efficient self-charging power system (SCPS) by integrating solid-state asymmetric supercapacitors device (SASD) and rotational triboelectric nanogenerator (RTENG) for efficient energy harvesting and storage. The designed nanostructure and interface contribute to high electrochemical reaction efficiency and stability. Moreover, the RTENG enables efficient energy harvesting. This research provides a new prospect for next-generation sustainable power sources.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Physical
Yuanzheng Zhang, Liping Zhou, Chengzhe Liu, Xiangyang Gao, Zhen Zhou, Shoupeng Duan, Qiang Deng, Lingpeng Song, Hong Jiang, Lilei Yu, Shishang Guo, Haiwu Zheng
Summary: Self-powered pacemakers with extended working time and reduced surgical risk hold promise for future clinical translation. This study presents a self-powered pacemaker based on an all-in-one piezoelectric nanogenerator, capable of valid myocardium pacing and conduction system pacing. Experimental results demonstrate successful pacing in a canine model at different pacing sites. This work provides a new idea for developing self-powered pacemakers with multifunctional features and integrated devices for in vivo diagnosis and treatment.
Article
Materials Science, Biomaterials
Jiapeng Han, Yuanzheng Zhang, Xiaofei Wang, Guocheng Zhang, Zhiyao Yu, Changyi Wang, Tianyou Xu, Zhen Zhou, Xiaomeng Yang, Xiaoxing Jin, Chenzhe Liu, Liping Zhou, Yueyi Wang, Baopeng Tang, Shishang Guo, Hong Jiang, Lilei Yu
Summary: This study aimed to modulate the inferior right ganglionated plexus (IRGP) of the heart and reduce the ventricular rate during rapid atrial pacing (RAP)-induced atrial fibrillation using ultrasound-mediated barium titanate nanoparticles (BTNPs). The results showed that ultrasound-mediated BTNP neuromodulation can significantly reduce the ventricular rate and may serve as a potential therapy for atrial fibrillation rate control.
BIOMATERIALS SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Zhuhao Wu, Zheng Ao, Hongwei Cai, Xiang Li, Bin Chen, Honglei Tu, Yijie Wang, Rongze Olivia Lu, Mingxia Gu, Liang Cheng, Xin Lu, Feng Guo
Summary: Cancer immunotherapy has potential for treating breast cancer, but predicting individual patient's response is challenging. Researchers developed a new method using acoustofluidic technology to assemble cell clusters from patient primary breast tumor dissociation within 2 minutes, allowing rapid and reliable evaluation of immunotherapy. This method offers a new approach for personalized cancer therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Correction
Biotechnology & Applied Microbiology
Yanyu Chen, Zhuhao Wu, Joseph Sutlive, Ke Wu, Lu Mao, Jiabao Nie, Xing-Zhong Zhao, Feng Guo, Zi Chen, Qinqin Huang
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Cuicui Su, Xiaocheng Huang, Lingling Zhang, Yuanzheng Zhang, Zhenhua Yu, Caleb Chen, Yumin Ye, Shishang Guo
Summary: This article reports a stable superhydrophobic antibacterial self-powered piezoelectric nanogenerator (PENG) sensor. The sensor is composed of a flexible electrospun poly(vinylidene fluoride-co-trifluoroethylene) piezoelectric nanofiber membrane, spray-coated interdigitated carbon nanotube electrodes, and a crosslinked hydrophobic nanocoating. It can accurately monitor human behaviors such as breathing and various motions, while providing self-cleaning, superhydrophobicity, and over 90% antibacterial rate. The sensor shows reliable and durable sensing performance under harsh environments and has been successfully integrated into shoe insoles for human gait monitoring.
Article
Engineering, Biomedical
Hongwei Cai, Zheng Ao, Chunhui Tian, Zhuhao Wu, Connor Kaurich, Zi Chen, Mingxia Gu, Andrea G. Hohmann, Ken Mackie, Feng Guo
Summary: Opioids may induce tolerance and hyperalgesia, but the human mechanisms underlying these effects are not well understood. Researchers have developed a novel human spinal microphysiological system (MPS) to model human nociception and opioid-induced tolerance. This system shows promising potential for studying pain etiology, screening new treatments, and validating novel therapeutics for human pain medicine.
BIOACTIVE MATERIALS
(2023)
Article
Computer Science, Information Systems
Min Wei, Yan Liu, Yuanhang Qu, Xiyu Gu, Yilin Wang, Wenjuan Liu, Yao Cai, Shishang Guo, Chengliang Sun
Summary: This paper presents the development of AlN/ScAlN SAW-based temperature sensors and the characterization of their temperature characteristics using three different methods. The experimental results show that all three sensors have good sensitivity and accuracy, making them suitable for temperature monitoring in various complex environments.
Article
Nanoscience & Nanotechnology
Bei Chen, Jingjing Zheng, Kefan Gao, Xuejia Hu, Shi-Shang Guo, Xing-Zhong Zhao, Fei Liao, Yi Yang, Wei Liu
Summary: We have developed a method that integrates optical force and fluorescent microspheres to simultaneously separate and identify CTCs. This method avoids the time-consuming and expensive immunofluorescence staining process, achieving efficient and rapid identification of sorted cells.
ACS APPLIED BIO MATERIALS
(2022)
Article
Medicine, Research & Experimental
Zheng Ao, Hongwei Cai, Zhuhao Wu, Liya Hu, Xiang Li, Connor Kaurich, Mingxia Gu, Liang Cheng, Xin Lu, Feng Guo
Summary: In this study, a microfluidics-based mini-tumor chip approach was developed to predict tumor responses to cancer immunotherapy. By generating mini-tumors on-chip and incorporating time-lapse live-cell imaging, the dynamic immune-tumor interactions and their responses to immunotherapy could be investigated within 36 hours.
Article
Chemistry, Multidisciplinary
Juan Li, Yu Xia, Fuling Zhou, Rongxiang He, Bolei Chen, Shishang Guo
Summary: In this work, a smart device integrating cell capture, in situ manipulation, and non-destructive release was designed to efficiently and rapidly capture cancer cells and deliver drugs. It has significant applications in medical treatment, tumor research, and drug development.
