4.8 Article

Self-powered pacemaker based on all-in-one flexible piezoelectric nanogenerator

期刊

NANO ENERGY
卷 99, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.nanoen.2022.107420

关键词

Piezoelectric nanogenerators; All-in-one; Self-powered pacemaker; Pacing sites; Valid pacing

资金

  1. National Key RAMP
  2. D Program of China [2020YFB2008800]
  3. National Natural Science Foundation of China [81871486, 81970287, 51872074]
  4. Foundation for Innovative Research Groups of Natural Science Foundation of Hubei Province, China [2021CFA010]
  5. Natural Science Foundation of Henan Province in China [212300410004]

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Self-powered pacemakers with extended working time and reduced surgical risk hold promise for future clinical translation. This study presents a self-powered pacemaker based on an all-in-one piezoelectric nanogenerator, capable of valid myocardium pacing and conduction system pacing. Experimental results demonstrate successful pacing in a canine model at different pacing sites. This work provides a new idea for developing self-powered pacemakers with multifunctional features and integrated devices for in vivo diagnosis and treatment.
Self-powered pacemakers hold great promise for future clinical translation by virtue of their extended working time and reduced high-risk repeated surgeries. Although self-powered pacemakers have been widely investigated, systematic research on their pacing results in different pacing sites is still lacking, which is crucial for expanding clinical application in the future. Here we design a self-powered pacemaker based on all-in-one piezoelectric nanogenerator (A-PENG) that can harvest biomechanical energy from the cardiac pulsation, enabling valid myocardium pacing and conduction system pacing. The A-PENG prepared by bonding is featured good stretchability, waterproofness, and biocompatibility, which can generate excellent electrical output with human movement. The A-PENG possesses higher stress transfer ability due to tailoring the distribution of the piezoelectric particles, thus enhancing output performance, which can be validated by the comparative experiment and simulation results. The maximum open-circuit (VOC) voltage and short-circuit current (ISC) are 3.1 and 3.0 times higher than routine piezocomposite films. The canine model exhibits valid pacing when the device releases electrical stimulus at right atrium, left ventricle, and His bundle. This work provides a new idea for developing self-powered pacemakers with multifunctional features and an integrated device for in vivo diagnosis and treatment.

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