Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells

Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment

(2015) Alberto M. Martelli et al.   Oncotarget

Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death

(2014) P Makhov et al.   BRITISH JOURNAL OF CANCER

Piperlongumine induces inhibition of the ubiquitin–proteasome system in cancer cells

(2013) Malin Jarvius et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fisetin inhibits growth, induces G2/M arrest and apoptosis of human epidermoid carcinoma A431 cells: role of mitochondrial membrane potential disruption and consequent caspases activation

(2013) Harish C. Pal et al.   EXPERIMENTAL DERMATOLOGY

Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes

(2013) Burkhard Kloesch et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Synthesis and evaluation of resveratrol derivatives as new chemical entities for cancer

(2013) Chaitanya Mulakayala et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Activation of ERK signaling and induction of colon cancer cell death by piperlongumine

(2013) H. Randhawa et al.   TOXICOLOGY IN VITRO

Apoptogenic activity of ethyl acetate extract of leaves of Memecylon edule on human gastric carcinoma cells via mitochondrial dependent pathway

(2013) VGM Naidu et al.   Asian Pacific Journal of Tropical Medicine

Targeting triple-negative breast cancer: optimising therapeutic outcomes

(2012) K. Gelmon et al.   ANNALS OF ONCOLOGY

Luteolin exerts anti-tumor activity through the suppression of epidermal growth factor receptor-mediated pathway in MDA-MB-231 ER-negative breast cancer cells

(2012) Eun-Ju Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cells through the intrinsic pathway with involvement of NF-κB signalling and G0/G1 cell cycle arrest: A bioassay-guided approach

(2012) Ismail Adam Arbab et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cellular Entry of Human Papillomavirus Type 16 Involves Activation of the Phosphatidylinositol 3-Kinase/Akt/mTOR Pathway and Inhibition of Autophagy

(2012) Z. Surviladze et al.   JOURNAL OF VIROLOGY

Methylseleninic Acid Enhances Paclitaxel Efficacy for the Treatment of Triple-Negative Breast Cancer

(2012) Yanfeng Qi et al.   PLoS One

Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells

(2012) Konstantin V. Golovine et al.   PROSTATE

PI3K and mTOR Signaling Pathways in Cancer: New Data on Targeted Therapies

(2012) Lise Willems et al.   Current Oncology Reports

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

(2011) Shinji Saiki et al.   Autophagy

Role of Bcl-2 family proteins and caspases in the regulation of apoptosis

(2011) Mohammad Shamsul Ola et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

GDC-0980 Is a Novel Class I PI3K/mTOR Kinase Inhibitor with Robust Activity in Cancer Models Driven by the PI3K Pathway

(2011) J. J. Wallin et al.   MOLECULAR CANCER THERAPEUTICS

PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity

(2011) J. Yuan et al.   MOLECULAR CANCER THERAPEUTICS

Cladosporol a stimulates G1-phase arrest of the cell cycle by up-regulation of p21waf1/cip1expression in human colon carcinoma HT-29 cells

(2011) Diana Zurlo et al.   MOLECULAR CARCINOGENESIS

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Antioxidant Activity of Glyceollins Derived from Soybean Elicited withAspergillus sojae

(2010) Hyo Jung Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mutant p53-induced Up-regulation of Mitogen-activated Protein Kinase Kinase 3 Contributes to Gain of Function

(2010) Aymone Gurtner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective induction of apoptosis through activation of caspase-8 in human leukemia cells (Jurkat) by dandelion root extract

(2010) P. Ovadje et al.   JOURNAL OF ETHNOPHARMACOLOGY

CK5/6, EGFR, Ki-67, cyclin D1, and nm23-H1 protein expressions as predictors of pathological complete response to neoadjuvant chemotherapy in triple-negative breast cancer patients

(2010) Xi-ru Li et al.   MEDICAL ONCOLOGY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The RCSB Protein Data Bank: redesigned web site and web services

(2010) P. W. Rose et al.   NUCLEIC ACIDS RESEARCH

Tannic acid ameliorates doxorubicin-induced cardiotoxicity and potentiates its anti-cancer activity: Potential role of tannins in cancer chemotherapy

(2010) Kulbhushan Tikoo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Discovery of the highly potent PI3K/mTOR dual inhibitor PF-04691502 through structure based drug design

(2010) Hengmiao Cheng et al.   MedChemComm

Triple-negative breast cancer--current status and future directions

(2009) O. Gluz et al.   ANNALS OF ONCOLOGY

Antinociceptive Effect of Crude Extract, Fractions and Three Alkaloids Obtained from Fruits of Piper tuberculatum

(2009) Rosely Valéria Rodrigues et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Possible treatment strategies for triple-negative breast cancer on the basis of molecular characteristics

(2009) Junichi Kurebayashi   Breast Cancer

Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells

(2008) Simone Reuter et al.   BIOCHEMICAL PHARMACOLOGY

Curcumin as “Curecumin”: From kitchen to clinic

(2007) Ajay Goel et al.   BIOCHEMICAL PHARMACOLOGY