Structural biology of the Bcl-2 family and its mimicry by viral proteins

Reconstitution of the Anti-Apoptotic Bcl-2 Protein into Lipid Membranes and Biophysical Evidence for Its Detergent-Driven Association with the Pro-Apoptotic Bax Protein

(2014) Marcus Wallgren et al.   PLoS One

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

(2013) Peter E. Czabotar et al.   CELL

Intracellular localization of the BCL-2 family member BOK and functional implications

(2013) N Echeverry et al.   CELL DEATH AND DIFFERENTIATION

Dual-site Interactions of p53 Protein Transactivation Domain with Anti-apoptotic Bcl-2 Family Proteins Reveal a Highly Convergent Mechanism of Divergent p53 Pathways

(2013) Ji-Hyang Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis

(2013) Ariele Viacava Follis et al.   Nature Chemical Biology

BID-induced structural changes in BAK promote apoptosis

(2013) Tudor Moldoveanu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Direct activation of full-length proapoptotic BAK

(2013) Elizaveta S. Leshchiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation

(2013) M. Gerlic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple Functions of BCL-2 Family Proteins

(2013) J. M. Hardwick et al.   Cold Spring Harbor Perspectives in Biology

Mechanisms of Action of Bcl-2 Family Proteins

(2013) A. Shamas-Din et al.   Cold Spring Harbor Perspectives in Biology

MCMV-mediated Inhibition of the Pro-apoptotic Bak Protein Is Required for Optimal In Vivo Replication

(2013) Peter Fleming et al.   PLoS Pathogens

BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax

(2012) F Wilfling et al.   CELL DEATH AND DIFFERENTIATION

The C-terminal helix of Bcl-xL mediates Bax retrotranslocation from the mitochondria

(2012) F Todt et al.   CELL DEATH AND DIFFERENTIATION

Non-apoptotic functions of apoptosis-regulatory proteins

(2012) Lorenzo Galluzzi et al.   EMBO REPORTS

Sheeppox Virus SPPV14 Encodes a Bcl-2-Like Cell Death Inhibitor That Counters a Distinct Set of Mammalian Proapoptotic Proteins

(2012) T. Okamoto et al.   JOURNAL OF VIROLOGY

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

(2012) Rhonda M. Perciavalle et al.   NATURE CELL BIOLOGY

Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA

(2012) J. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multipolar functions of BCL-2 proteins link energetics to apoptosis

(2012) J. Marie Hardwick et al.   TRENDS IN CELL BIOLOGY

Evolution of Bcl-2 homology motifs: homology versus homoplasy

(2012) Abdel Aouacheria et al.   TRENDS IN CELL BIOLOGY

The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist

(2012) G J P Rautureau et al.   Cell Death & Disease

Bax Activation Initiates the Assembly of a Multimeric Catalyst that Facilitates Bax Pore Formation in Mitochondrial Outer Membranes

(2012) Yulia Kushnareva et al.   PLOS BIOLOGY

Protein–surfactant interactions: A tale of many states

(2011) Daniel Otzen   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

(2011) Frank Edlich et al.   CELL

BCL2A1: the underdog in the BCL2 family

(2011) M Vogler   CELL DEATH AND DIFFERENTIATION

Cell death by autophagy: facts and apparent artefacts

(2011) D Denton et al.   CELL DEATH AND DIFFERENTIATION

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

(2011) Andreas Strasser et al.   EMBO JOURNAL

Structural Determinants of Caspase-9 Inhibition by the Vaccinia Virus Protein, F1L

(2011) Eric Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of anti-apoptotic BCL2-proteins by non-canonical interactions: The next step forward or two steps back?

(2011) Levi J. Beverly   JOURNAL OF CELLULAR BIOCHEMISTRY

Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

(2011) Andrew W. Roberts et al.   JOURNAL OF CLINICAL ONCOLOGY

Crystal Structure of a BCL-W Domain-Swapped Dimer: Implications for the Function of BCL-2 Family Proteins

(2011) Erinna F. Lee et al.   STRUCTURE

BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore

(2011) Loren D. Walensky et al.   TRENDS IN BIOCHEMICAL SCIENCES

Autophagy and apoptosis: what is the connection?

(2011) Jacob M. Gump et al.   TRENDS IN CELL BIOLOGY

Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence

(2011) Carlos Maluquer de Motes et al.   PLoS Pathogens

Bcl-2 proteins and mitochondria—Specificity in membrane targeting for death

(2010) Jennefer Lindsay et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Apoptosis: embedded in membranes

(2010) Christian Bogner et al.   CURRENT OPINION IN CELL BIOLOGY

Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis

(2010) Gilles J. P. Rautureau et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heterodimerization of BAK and MCL-1 Activated by Detergent Micelles

(2010) Qian Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deerpox Virus Encodes an Inhibitor of Apoptosis That Regulates Bak and Bax

(2010) L. Banadyga et al.   JOURNAL OF VIROLOGY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of a Novel Interaction between Bcl-2 Members Diva and Harakiri

(2010) Lorenzo Sborgi et al.   PLoS One

Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1

(2010) Marc Kvansakul et al.   PLoS Pathogens

BCL2DB: moving ‘helix-bundled’ BCL-2 family members to their database

(2009) Stanislas Valentin Blaineau et al.   APOPTOSIS

The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax

(2009) Dana Westphal et al.   APOPTOSIS

Mapping the Interaction of Pro-Apoptotic tBID with Pro-Survival BCL-XL

(2009) Yong Yao et al.   BIOCHEMISTRY

Vaccinia Virus Protein F1L Is a Caspase-9 Inhibitor

(2009) Dayong Zhai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis

(2009) G. Dewson et al.   JOURNAL OF CELL SCIENCE

Emerging Role for Members of the Bcl-2 Family in Mitochondrial Morphogenesis

(2009) Arnaud Autret et al.   MOLECULAR CELL

Death receptor signal transducers: nodes of coordination in immune signaling networks

(2009) Nicholas S Wilson et al.   NATURE IMMUNOLOGY

Bid: a Bax-like BH3 protein

(2009) L P Billen et al.   ONCOGENE

An Epstein-Barr Virus Anti-Apoptotic Protein Constitutively Expressed in Transformed Cells and Implicated in Burkitt Lymphomagenesis: The Wp/BHRF1 Link

(2009) Gemma L. Kelly et al.   PLoS Pathogens

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

(2008) Jonathan F. Lovell et al.   CELL

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

(2008) M Kvansakul et al.   CELL DEATH AND DIFFERENTIATION

Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1

(2008) Catherine L. Day et al.   JOURNAL OF MOLECULAR BIOLOGY

Poxvirus K7 Protein Adopts a Bcl-2 Fold: Biochemical Mapping of Its Interactions with Human DEAD Box RNA Helicase DDX3

(2008) Arnout P. Kalverda et al.   JOURNAL OF MOLECULAR BIOLOGY

Murine Cytomegalovirus m38.5 Protein Inhibits Bax-Mediated Cell Death

(2008) I. Jurak et al.   JOURNAL OF VIROLOGY

To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions

(2008) Grant Dewson et al.   MOLECULAR CELL

BAX activation is initiated at a novel interaction site

(2008) Evripidis Gavathiotis et al.   NATURE

BCL-2 family antagonists for cancer therapy

(2008) Guillaume Lessene et al.   NATURE REVIEWS DRUG DISCOVERY

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax

(2008) J. I. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1

(2008) Callum Smits et al.   STRUCTURE

Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis

(2008) Stephen C. Graham et al.   PLoS Pathogens

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY