The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

(2010) L. Happo et al.   BLOOD

Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance

(2010) K. J. Campbell et al.   BLOOD

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

(2010) D. Ren et al.   SCIENCE

Mcl-1 Is Essential for Germinal Center Formation and B Cell Memory

(2010) I. Vikstrom et al.   SCIENCE

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis

(2009) E M Michalak et al.   CELL DEATH AND DIFFERENTIATION

The ups and downs of Myc biology

(2009) Laura Soucek et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

MCL-1–dependent leukemia cells are more sensitive to chemotherapy than BCL-2–dependent counterparts

(2009) Joslyn K. Brunelle et al.   JOURNAL OF CELL BIOLOGY

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins

(2009) Delphine Mérino et al.   JOURNAL OF CELL BIOLOGY

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

(2008) E M Michalak et al.   CELL DEATH AND DIFFERENTIATION

Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

(2008) Mark S. Cragg et al.   JOURNAL OF CLINICAL INVESTIGATION

Selection against PUMA Gene Expression in Myc-Driven B-Cell Lymphomagenesis

(2008) S. P. Garrison et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins

(2008) J. E. Chipuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

(2008) Jerry E. Chipuk et al.   TRENDS IN CELL BIOLOGY

Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax

(2008) Lieven P Billen et al.   PLOS BIOLOGY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY