Article
Microbiology
Kai Zhang, Ning Jiang, Xiaoyu Sang, Ying Feng, Ran Chen, Qijun Chen
Summary: T. brucei LPG stimulates neutrophils to form NETs and release ROS, with the involvement of TLR2 and TLR4, where JNK phosphorylation plays a critical role.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jiao Luo, Xiujun Tan, Ling Ye, Chenglin Wang
Summary: The study reveals that the JNK signaling pathway plays a positive role in the formation of dental papilla cell polarity, as indicated by the up-regulation of polarity-related genes and rescue effects of RhoA Q63L mutant. JNK activation is linked to polarization, migration, and differentiation of dental papilla cells, highlighting its importance in tooth development.
Article
Endocrinology & Metabolism
Jun-Chi Yu, Jia-Zhi Lu, Xiao-Yu Cui, Lei Guo, Zhi-Jun Wang, Yu-Dong Liu, Feng Wang, Ming-Fang Qi, Yu-Feng Liu, Tian-Lai Li
Summary: The study revealed that melatonin regulates ROS homeostasis and delays leaf aging in tomato plants through the modulation of SlCV gene expression.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yuta Semba, Shintaro Yamamoto, Shunsuke Takahashi, Takahisa Shinomiya, Yukitoshi Nagahara
Summary: Masitinib induces apoptosis in c-kit-negative HepG2 cells by targeting the redox balance through the JNK pathway, demonstrating its anticancer effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Ophthalmology
Lei Tao, Danxue He, Chunyan Liao, Binxiang Cai, Chao Chen, Yan Wang, Jingmeng Chen, Zuguo Liu, Yalin Wu
Summary: The study reveals that the activation of c-Jun N-terminal kinase (JNK) by all-trans-retinal (atRAL) contributes to the apoptosis of retinal pigment epithelium (RPE) cells, which is associated with dry age-related macular degeneration (AMD) and Stargardt's disease. Inhibiting JNK signaling can prevent the apoptosis of RPE cells induced by atRAL, offering a potential therapeutic target for related retinal diseases.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Fang Liu, Yan Liu, Qifeng Peng, Guodong Wang, Qing Tan, Zhongyue Ou, Qishan Xu, Chixiang Liu, Daming Zuo, Jianbo Zhao
Summary: This study revealed that creatinine is closely related to drug-induced liver injury and exacerbates APAP-induced hepatocyte death by promoting the production and activation of reactive oxygen species and c-Jun N-terminal kinase.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Junlong Zhong, Bin Wang, Biao Wu, Jie Shang, Ning Jiang, Aiyong Cui, Yufeng Chen, Xianghe Xu, Huading Lu
Summary: This study found that Clock expression is up-regulated in OA cartilage and Clock knockdown can attenuate ROS-mediated chondrocyte senescence by restoring autophagic flux, providing a potential therapeutic target for OA.
Article
Biochemistry & Molecular Biology
Hae Dong Jeong, Jin Hyung Kim, Go Eun Kwon, Seung-Taek Lee
Summary: Polyamine oxidase (PAOX) is an enzyme involved in the polyamine catabolism pathway and plays a crucial role in skin aging by generating hydrogen peroxide. Our study found that PAOX expression increased the secretion of MMP-1 and collagen degradation in fibroblast cultures, and this effect was mediated through the activation of specific signaling pathways and the increase in ROS levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agronomy
Rui Huang, Canying Li, Mi Guo, Hengping Xu, Shuran Zhang, Miao Wang, Yonghong Ge
Summary: The current study found that dipping `Qiujin' apples in caffeic acid significantly inhibited respiratory rate, ethylene release rate, and hydrogen peroxide accumulation. It also increased the levels of reduced glutathione and ascorbic acid in the apples. Caffeic acid improved the activities and gene expressions of several key enzymes in the fruit, and suppressed senescence after harvest.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hyunwook Cho, Jung-Mi Hah
Summary: JNK3 plays a crucial role in neurodegenerative diseases, and this study summarizes the research on JNK3 inhibitors, focusing on structural and docking insights.
Article
Gastroenterology & Hepatology
Zhigang Fang, Hyeong-Geug Kim, Menghao Huang, Kushan Chowdhury, Ming O. Li, Suthat Liangpunsakul, X. Charlie Dong
Summary: This study demonstrates the protective role of Sesn1/2/3 in hepatic lipotoxicity-induced oxidative stress by reducing JNK phosphorylation and activity, leading to decreased lipotoxicity and oxidative stress in liver cells.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Plant Sciences
Heewon Song, Yong Yook Lee, Joonwoo Park, YoungJoo Lee
Summary: The study evaluated the protective effect of Korean Red Ginseng (KRG) on BPA-induced ROS generation, COX-2, and MMP-9 expression in A549 cells. The results showed that KRG significantly suppressed BPA-induced NF-κB activity, cell migration, and MMP-9 expression. This suggests a potential therapeutic application of KRG for BPA-induced inflammatory disorders.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Stefania Magnano, Patricia Hannon Barroeta, Ronan Duffy, Jeff O'Sullivan, Daniela M. Zisterer
Summary: The study evaluated the role of autophagy in mediating cisplatin resistance in oral squamous cell carcinoma (OSCC) cells. Results demonstrated that cisplatin induces both apoptosis and autophagy in OSCC cells through the ROS/JNK pathway. However, autophagy did not play a significant role in acquired resistance to cisplatin or have a pro-survival effect in the cells. This suggests a complex interplay between apoptosis and autophagy pathways in OSCC.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Li-fang Liu, Yun Hu, Yi-nuo Liu, De-wen Shi, Chang Liu, Xin Da, Si-hui Zhu, Qian-yun Zhu, Ji-qian Zhang, Guang-hong Xu
Summary: This study found that ROS may regulate blood-brain barrier permeability in aged mice with postoperative delirium via the CypA/MMP9 pathway, suggesting that CypA may be a potential molecular target for preventing POD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Jing Tan, Wei Gao, Wanchao Yang, Xianzhang Zeng, Linlin Wang, Xiaoguang Cui
Summary: JNK1 exacerbates ischemia-reperfusion injury in lung transplantation, while JNK2 alleviates it. JNK1 silencing attenuates lung graft dysfunction by inhibiting inflammation and apoptosis.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Nicole L. Shakerley, Akshaya Chandrasekaran, Mohamed Trebak, Barbara A. Miller, J. Andres Melendez
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Seham M. Rabadi, Belkys C. Sanchez, Mrudula Varanat, Zhuo Ma, Sally V. Catlett, Juan Andres Melendez, Meenakshi Malik, Chandra Shekhar Bakshi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Medicine, Research & Experimental
Donald A. McCarthy, Ahmad A. Nazem, James McNeilan, Nicole L. Shakerley, Ryan R. Clark, Maria D. Idelchik, Mehmet Yigit, J. Andres Melendez
EXPERIMENTAL BIOLOGY AND MEDICINE
(2016)
Review
Oncology
Maria del Pilar Sosa Idelchik, Ulrike Begley, Thomas J. Begley, J. Andres Melendez
SEMINARS IN CANCER BIOLOGY
(2017)
Review
Biochemistry & Molecular Biology
Akshaya Chandrasekaran, Maria del Pilar Sosa Idelchik, J. Andres Melendez
Article
Cell Biology
Timothy Masiello, Atul Dhall, L. P. Madhubhani Hemachandra, Natalya Tokranova, J. Andres Melendez, James Castracane
Review
Biochemistry & Molecular Biology
Andrea Leonardi, Sara Evke, May Lee, J. Andres Melendez, Thomas J. Begley
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
May Y. Lee, Andrea Leonardi, Thomas J. Begley, J. Andres Melendez
Article
Biochemistry & Molecular Biology
Andrea Leonardi, Nataliia Kovalchuk, Lei Yin, Lauren Endres, Sara Evke, Steven Nevins, Samuel Martin, Peter C. Dedon, J. Andres Melendez, Laura Van Winkle, Qing-Yu Zhang, Xinxin Ding, Thomas J. Begley
Article
Medicine, Research & Experimental
Akshaya Chandrasekaran, May Y. Lee, Xuexin Zhang, Shaheen Hasan, Haban Desta, Scott A. Tenenbaum, J. Andres Melendez
EXPERIMENTAL BIOLOGY AND MEDICINE
(2020)
Article
Medicine, Research & Experimental
Isra Mahaboob, Roger J. Reinertsen, Benjamin McEwen, Kasey Hogan, Emma Rocco, J. Andres Melendez, Nathaniel C. Cady, F. Shahedipour-Sandvik
Summary: The study demonstrated the potential of an AlGaN/GaN high electron mobility transistor sensor for detecting reactive and transient biological molecules like hydrogen peroxide. The use of a boronate-based fluorescent probe allowed for real-time measurement of hydrogen peroxide levels, showcasing the dynamic measurement capability of the sensor in monitoring reactive oxygen species reactions.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Review
Medicine, Research & Experimental
May Y. Lee, Stephen Ojeda-Britez, Dylan Ehrbar, Antonia Samwer, Thomas J. Begley, J. Andres Melendez
Summary: Selenium is a naturally occurring trace element that provides multiple benefits, such as antioxidant, anticancer, and antiaging effects, as well as immune system boosting. Selenium is unique in its incorporation as selenocysteine, a rare 21st amino acid, into selenoproteins, which serve as crucial antioxidant enzymes for maintaining redox homeostasis. The deficiency of selenoproteins can lead to increased oxidative stress and cellular senescence.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Sabrina M. Huber, Ulrike Begley, Anwesha Sarkar, William Gasperi, Evan T. Davis, Vasudha Surampudi, May Lee, J. Andres Melendez, Peter C. Dedon, Thomas J. Begley
Summary: Cells respond to environmental stress by regulating gene expression at the level of both transcription and translation. The dynamic regulation of transfer RNA (tRNA) wobble modifications leads to selective translation of stress response proteins. This study reveals that the response of human hepatocellular carcinoma cells to arsenite exposure is regulated by the availability of queuine, a precursor to tRNA wobble modification. Limiting queuine leads to cell death, altered translation, increased reactive oxygen species levels, and mitochondrial dysfunction.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Medicine, Research & Experimental
Juan Andres Melendez
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Review
Physiology
Maria del Pilar Sosa Pena, Reynold Lopez-Soler, J. Andres Melendez
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2018)