期刊
CURRENT MICROBIOLOGY
卷 62, 期 3, 页码 703-709出版社
SPRINGER
DOI: 10.1007/s00284-010-9767-2
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资金
- State Major Science and Technology Special Projects of China [2008ZX1004-008]
- National Natural Science Foundation of China [30670104]
Plasmid incompatibility, which has no effect on other plasmids or chromosomal genes, can be used to cure a target plasmid. In this report, we successfully cured the plasmid pXO2 from Bacillus anthracis A16 with a newly constructed, incompatible plasmid pKSV7-oriIV and obtained a new pXO2-cured strain, designated A16PI2. This is the first time that a plasmid was cured from the B. anthracis wild-type strain A16 utilizing this principle, which could be considered as an efficacious method to cure large plasmids.
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