Editorial Material
Biochemistry & Molecular Biology
Noa Hourvitz
Summary: Noa Hourvitz is a graduate of the STEP Program, which supports Israeli and Palestinian students to study together for their graduate degrees. In her writing, she discusses the friendship she formed with her STEP partner and how science helped overcome political barriers.
Article
Immunology
Rekha Arya, Truc Kim, Joo Won Youn, Taeok Bae, Kyeong Kyu Kim
Summary: This study identified a compound called SKKUCS that can inhibit the expression of virulence genes in Staphylococcus aureus. In vivo experiments showed that SKKUCS had good efficacy and toxicity in treating drug-resistant staphylococcal infections. This suggests that SKKUCS could be a potential antivirulence drug.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Geriatrics & Gerontology
Lee E. Neilson, Joseph F. Quinn, Miranda M. Lim
Summary: As the prevalence of Parkinson's disease grows, identifying the population at-risk of developing PD in the prodromal period becomes essential. Lifestyle modifications in this early stage may alter the disease trajectory.
Review
Geriatrics & Gerontology
Lee E. Neilson, Joseph F. Quinn, Miranda M. Lim
Summary: As the prevalence of Parkinson's disease (PD) increases, it is important to identify and intervene in the prodromal period to potentially alter the disease trajectory. This period can include those with subtle motor deficits or physiological markers of the disease. A comprehensive review of literature on risk factors and prodromal symptoms of PD is provided, suggesting the need for prospective studies to develop strategies for identifying and modulating disease progression.
Article
Humanities, Multidisciplinary
Andrea Butcher, Jose A. Canada, Salla Sariola
Summary: The narrow approach to managing antimicrobial resistance overlooks the socio-economic and material drivers of antibiotic decision-making, posing challenges for low-resource regions. A global AMR policy should focus on local specificity instead of enforcing universal standardization.
HUMANITIES & SOCIAL SCIENCES COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Shakhinur Islam Mondal, Arzuba Akter, Lorraine A. Draper, R. Paul Ross, Colin Hill
Summary: Clostridioides difficile is a life-threatening enteric pathogen, and microbial disruption caused by antibiotics is linked to its infection. The study found that CWH351-656 derived from bacteriophages has therapeutic potential against C. difficile infection by preventing spore germination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Oncology
Theresa A. Boyle, Aaron D. Bossler
Summary: DNA is the sequence that codes for proteins, and messenger RNA is transcribed from the DNA sequence and translated into protein. It is difficult to predict the effects of DNA changes on messenger RNA and protein quantity and quality. DNA translocation changes can cause sequences from different genes or gene parts to join together. DNA sequencing is used clinically to predict the effects of DNA changes on proteins, and RNA sequencing provides a more direct measure of these effects. This sequencing is important for identifying changes in cancer that may indicate response to targeted therapy, prognosis, or diagnosis.
Review
Pharmacology & Pharmacy
Sitah Alharthi, Seyed Ebrahim Alavi, Peter Michael Moyle, Zyta Maria Ziora
Summary: Virulence factor SrtA plays a crucial role in the pathogenesis of Gram-positive superbugs and is an ideal target for antivirulence drug development. Inhibitors targeting SrtA, including synthetic small molecules, peptides, and natural products, show promise in overcoming antimicrobial resistance (AMR) in bacteria expressing AMR. Future research on SrtA may lead to alternative drug development strategies in the face of antibiotic resistance.
DRUG DISCOVERY TODAY
(2021)
Article
Computer Science, Cybernetics
Fei-Yue Wang, Rui Qin, Yizhu Chen, Yonglin Tian, Xiao Wang, Bin Hu
Summary: This issue of IEEE TCSS presents the latest developments and high-quality research results, focusing on the concept of federated ecology as a new solution to the problem of data isolation in the era of big data.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2021)
Review
Cardiac & Cardiovascular Systems
Patrick R. Lawler, Deepak L. Bhatt, Lucas C. Godoy, Thomas F. Luscher, Robert O. Bonow, Subodh Verma, Paul M. Ridker
Summary: Systemic vascular inflammation plays crucial roles in the progression and destabilization of ASCVD, requiring more individualized approaches for successful clinical translation. High-sensitivity C-reactive protein may serve as a clinical measure of inflammation.
EUROPEAN HEART JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Sankarganesh Krishnamoorthy, Andrea K. Steiger, William C. Nelson, Robert G. Egbert, Aaron T. Wright
Summary: Development of profiling strategies for understanding enzymes involved in bacterial infections is crucial. A selective activity-based probe has been developed to target a highly conserved enzyme, C5a peptidase, and inhibit its activity. This probe enables specific detection and isolation of C5a peptidase-expressing pathogens in microbial mixtures.
CHEMICAL COMMUNICATIONS
(2022)
Article
Psychology, Biological
Eric-Jan Wagenmakers, Alexandra Sarafoglou, Sil Aarts, Casper Albers, Johannes Algermissen, Stepan Bahnik, Noah van Dongen, Rink Hoekstra, David Moreau, Don van Ravenzwaaij, Aljaz Sluga, Franziska Stanke, Jorge Tendeiro, Balazs Aczel
Summary: This article presents seven statistical procedures that increase transparency in data analysis, aiming to promote transparent practices in social and behavioral sciences. These procedures highlight common ground among data analysts from different schools and find inspiration in the ethos of science.
NATURE HUMAN BEHAVIOUR
(2021)
Review
Chemistry, Medicinal
Harlei Martin, Kevin Kavanagh, Trinidad Velasco-Torrijos
Summary: This article focuses on how small molecules disrupt the biosynthesis of fungal cell wall components and membrane structure, prevent the localization of GPI-anchor proteins, inhibit the production of enzymes involved in adhesion, downregulate genes encoding adhesins, and competitively inhibit receptor interactions, ultimately reducing the adhesion of C. albicans to host cells and paving the way for new classes of antifungal agents.
FUTURE MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Kathryn R. Brink, Maxwell G. Hunt, Andrew M. Mu, Ken Groszman, Ky V. Hoang, Kevin P. Lorch, Brett H. Pogostin, John S. Gunn, Jeffrey J. Tabor
Summary: In this study, a display method was developed to investigate the effects of human antimicrobial peptides (AMPs) on the pathogenesis-regulating TCS PhoPQ of Salmonella Typhimurium. The study found that PhoPQ can sense AMPs with diverse sequences, structures, and biological functions. Machine learning was used to identify peptide sub-domains and biophysical features linked to PhoPQ activation.
NATURE CHEMICAL BIOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Scott Marshall, Malidi Ahamadi, Jenny Chien, Daisuke Iwata, Pavel Farkas, Augusto Filipe, Nicolas Frey, Erin Greene, Norisuke Kawai, Jian Li, Jorg Lippert, Flora Musuamba Tshinanu, Efthymios Manolis, Mark C. Peterson, Sarem Sarem, Mohamad Shebley, Million Tegenge, Chia-Hsun Tsai, Chien-Lung Tu, Yasuto Otsubo, Jiawei Wei, Lucia Zhang, Hao Zhu, Kristin E. Karlsson
Summary: Consistency in planning, conduct, reporting, and regulatory review of model-informed drug development (MIDD) applications requires global alignment of expectations. An International Council for Harmonization (ICH) MIDD general principles guideline has been established to provide a common standard of practice and a framework for risk-based assessment of MIDD-derived evidence in global regulatory decision-making. This perspective outlines the background, viewpoints, and future steps in the development of this guideline.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)