Orexin Receptors: Pharmacology and Therapeutic Opportunities

Is Low Histamine a Fundamental Cause of Sleepiness in Narcolepsy and Idiopathic Hypersomnia?

(2017) Thomas E. Scammell et al.   SLEEP

Localized Loss of Hypocretin (Orexin) Cells in Narcolepsy Without Cataplexy

(2017) Thomas C. Thannickal et al.   SLEEP

Abnormal Sleep/Wake Dynamics in Orexin Knockout Mice

(2017) Cecilia G. Diniz Behn et al.   SLEEP

Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists

(2010) Paul J. Coleman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Orexin receptor antagonists: a review of promising compounds patented since 2006

(2010) Paul J Coleman et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Neural bases for addictive properties of benzodiazepines

(2010) Kelly R. Tan et al.   NATURE

Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintenance of basal sleep/wake states

(2009) M. Hondo et al.   Acta Physiologica

Activation of the basal forebrain by the orexin/hypocretin neurones

(2009) E. Arrigoni et al.   Acta Physiologica

Loss of hypocretin (orexin) neurons with traumatic brain injury

(2009) Christian R. Baumann et al.   ANNALS OF NEUROLOGY

Involvement of TRPC3 channels in calcium oscillations mediated by OX1 orexin receptors

(2009) Hanna M. Peltonen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Conformational analysis of N,N-disubstituted-1,4-diazepane orexin receptor antagonists and implications for receptor binding

(2009) Christopher D. Cox et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hypocretin/orexin in arousal and stress

(2009) Craig W. Berridge et al.   BRAIN RESEARCH

Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX2 receptor

(2009) P Malherbe et al.   BRITISH JOURNAL OF PHARMACOLOGY

Discovery of a Potent, CNS-Penetrant Orexin Receptor Antagonist Based on anN,N-Disubstituted-1,4-diazepane Scaffold that Promotes Sleep in Rats

(2009) David B. Whitman et al.   ChemMedChem

Behavioural and neurophysiological correlates of human cataplexy: A video-polygraphic study

(2009) Roberto Vetrugno et al.   CLINICAL NEUROPHYSIOLOGY

REM Sleep Behavior Disorder and Narcolepsy

(2009) Michel Billiard   CNS & Neurological Disorders-Drug Targets

Hypocretin /orexin contributes to the expression of some but not all forms of stress and arousal

(2009) Teri M. Furlong et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system

(2009) Rodrigo A. España et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Biomedical Application of Orexin/Hypocretin Receptor Ligands in Neuroscience

(2009) Christoph Boss et al.   JOURNAL OF MEDICINAL CHEMISTRY

Psychological health in central hypersomnias: the French Harmony study

(2009) Y Dauvilliers et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neuroendocrine Proopiomelanocortin Neurons Are Excited by Hypocretin/Orexin

(2009) C. Acuna-Goycolea et al.   JOURNAL OF NEUROSCIENCE

Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers

(2009) S. L. Borgland et al.   JOURNAL OF NEUROSCIENCE

Blockade of Orexin-1 Receptors Attenuates Orexin-2 Receptor Antagonism-Induced Sleep Promotion in the Rat

(2009) C. Dugovic et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness

(2009) Mirela Barros Dias et al.   JOURNAL OF PHYSIOLOGY-LONDON

Biochemical and Electrophysiological Characterization of Almorexant, a Dual Orexin 1 Receptor (OX1)/Orexin 2 Receptor (OX2) Antagonist: Comparison with Selective OX1 and OX2 Antagonists

(2009) P. Malherbe et al.   MOLECULAR PHARMACOLOGY

The orexin-1 receptor antagonist SB-334867 reduces amphetamine-evoked dopamine outflow in the shell of the nucleus accumbens and decreases the expression of amphetamine sensitization

(2009) Davide Quarta et al.   NEUROCHEMISTRY INTERNATIONAL

Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure

(2009) Christopher J. Winrow et al.   NEUROPHARMACOLOGY

Orexin/hypocretin is necessary for context-driven cocaine-seeking

(2009) Rachel J. Smith et al.   NEUROPHARMACOLOGY

Orexin Mediates the Expression of Precipitated Morphine Withdrawal and Concurrent Activation of the Nucleus Accumbens Shell

(2008) Ruth Sharf et al.   BIOLOGICAL PSYCHIATRY

Proline bis-amides as potent dual orexin receptor antagonists

(2008) Jeffrey M. Bergman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats

(2008) S G Nair et al.   BRITISH JOURNAL OF PHARMACOLOGY

Orexin Receptor Antagonists: Medicinal Chemistry and Therapeutic Potential

(2008) Anthony Roecker et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons

(2008) S. L. Borgland et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Dual Orexin Actions on Dorsal Raphe and Laterodorsal Tegmentum Neurons: Noisy Cation Current Activation and Selective Enhancement of Ca2+ Transients Mediated by L-Type Calcium Channels

(2008) K. A. Kohlmeier et al.   JOURNAL OF NEUROPHYSIOLOGY

Insular hypocretin transmission regulates nicotine reward

(2008) J. A. Hollander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Do enteric neurons make hypocretin?

(2008) Christian R. Baumann et al.   REGULATORY PEPTIDES

The orexin system regulates alcohol-seeking in rats

(2006) Andrew J Lawrence et al.   BRITISH JOURNAL OF PHARMACOLOGY