Article
Neurosciences
Shuntaro Uchida, Shingo Soya, Yuki C. Saito, Arisa Hirano, Keisuke Koga, Makoto Tsuda, Manabu Abe, Kenji Sakimura, Takeshi Sakurai
Summary: This study identified a specific subpopulation of Gly(VMM) neurons in the ventromedial medulla that are involved in generating muscle atonia during REM sleep. Silencing this circuit resulted in REM sleep without muscle atonia and reduced time spent in cataplexy-like episodes. Additionally, Gly(VMM) neurons also play a crucial role in maintaining sleep and cataplexy.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Markus H. Schmidt, Claudio L. A. Bassetti
Summary: Three papers published in SLEEP using different mouse models of narcolepsy indicate significant gender differences in the expression of narcolepsy symptoms. Female mice exhibit more cataplexy events and greater overall cataplexy expression compared to males. Additionally, female mice in the neurotoxic DTA mouse model experience cataplexy symptoms earlier than males during the loss of Hcrt cells. Furthermore, the occurrence of cataplexy is twice as frequent during the estrous phase in females. These findings highlight the need for further research on gender differences in human narcolepsy.
Article
Multidisciplinary Sciences
Emi Hasegawa, Ai Miyasaka, Katsuyasu Sakurai, Yoan Cherasse, Yulong Li, Takeshi Sakurai
Summary: The sleep cycle involves alternating non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. A transient increase of dopamine in the basolateral amygdala terminates NREM sleep and initiates REM sleep, playing a critical role in sleep cycle generation. This mechanism is also implicated in cataplectic attacks in narcoleptics.
Article
Medicine, General & Internal
Takashi Ando, Masakazu Wakai, Takashi Kanbayashi, Masahisa Katsuno
Summary: The 57-year-old male patient presented with late-onset narcolepsy type 1 with status cataplecticus, showing symptoms such as dysarthria, limb weakness, and staggering gait. Multiple tests revealed REM sleep excess and sleep-onset REM periods, while clomipramine was effective in relieving his neurological symptoms.
Letter
Neurosciences
Fang-Fang Fan, Vetrivelan Ramalingam, Yi Yang, Zhen-Ni Guo, Jun Lu
Summary: The Pontine sub-laterodorsal tegmental nucleus (SLD) is crucial for REM sleep, cataplexy, and emotion memory. Focal ablation of SLD neurons eliminated REM sleep, reduced cataplexy and altered EEG patterns. REM sleep elimination increased anxiety-like behaviors and impaired fear extinction. These findings suggest that SLD plays a vital role in regulating REM sleep, emotion, and fear extinction.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biology
Dong Yeon Son, Hyun Bin Kwon, Dong Seok Lee, Hyung Won Jin, Jong Hyeok Jeong, Jeehoon Kim, Sang Ho Choi, Heenam Yoon, Mi Hyun Lee, Yu Jin Lee, Kwang Suk Park
Summary: This study aimed to establish new biomarkers for narcolepsy by analyzing the network connectivity of biosignals during nocturnal sleep. The results showed that during rapid eye movement sleep, narcolepsy patients displayed more connections compared to healthy controls, with potential for these connectivity differences to be used as biomarkers. The classifier based on these differences had a high sensitivity, specificity, and accuracy, indicating the potential of network connectivity as a biomarker for identifying differences between narcolepsy patients and healthy controls.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Genetics & Heredity
Taku Miyagawa, Susumu Tanaka, Mihoko Shimada, Noriaki Sakai, Kotomi Tanida, Nozomu Kotorii, Tatayu Kotorii, Yu Ariyoshi, Yuji Hashizume, Kimihiro Ogi, Hiroshi Hiejima, Takashi Kanbayashi, Aya Imanishi, Azusa Ikegami, Yuichi Kamei, Akiko Hida, Yamato Wada, Masayuki Miyamoto, Masanori Takami, Hideaki Kondo, Yoshiyuki Tamura, Yukari Taniyama, Naoto Omata, Tomoyuki Mizuno, Shunpei Moriya, Hirokazu Furuya, Mitsuhiro Kato, Kayoko Kato, Jun Ishigooka, Kazuhito Tsuruta, Shigeru Chiba, Naoto Yamada, Masako Okawa, Koichi Hirata, Kenji Kuroda, Kazuhiko Kume, Naohisa Uchimura, Masaaki Kitada, Tohru Kodama, Yuichi Inoue, Seiji Nishino, Kazuo Mishima, Katsushi Tokunaga, Makoto Honda
Summary: Idiopathic hypersomnia is a rare sleep disorder characterized by excessive daytime sleepiness. A study in a Japanese population identified a rare variant associated with this disorder, which results in decreased signaling through orexin receptors, similar to narcolepsy type 1.
NPJ GENOMIC MEDICINE
(2022)
Review
Neurosciences
Yi-Qun Wang, Wen-Ying Liu, Lei Li, Wei-Min Qu, Zhi-Li Huang
Summary: REM sleep is believed to be associated with dreaming, but the mechanisms of its generation are still unclear. Several models have been established to explain REM sleep. REM sleep behavior disorder and narcolepsy are two common disorders related to REM sleep.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Lucie Barateau, Michel Lecendreux, Sofiene Chenini, Anna Laura Rassu, Regis Lopez, Carole Pesenti, Isabelle Jaussent, Severine Beziat, Yves Dauvilliers
Summary: The study validated the Narcolepsy Severity Scale (NSS) in adults with narcolepsy type 1 (NT1) and developed the Pediatric NSS (NSS-P). Through a survey of 209 children and adolescents, it was found that NSS-P has good psychometric properties and reliability in pediatric NT1 patients.
Article
Clinical Neurology
Utku Ogan Akyildiz, F. Irsel Tezer, Guray Koc, Sevda Ismailogullari, Aylin Bican Demir, Aysin Kisabay Ak, Gulin Sunter, Kezban Aslan Kara, Deniz Tuncel Berktas, Aysenur Sahin, Filiz Azman, Bulent Devrim Akcay, Duygu Kurt Gok, Hikmet Yilmaz, Kadriye Agan, Yavuz Bekmezci, Sinan Yetkin, Murat Aksu, Derya Karadeniz, Gulcin Benbir Senel
Summary: This study aimed to evaluate the characteristics of REM sleep in patients with narcolepsy. The results showed that the increase in REM density during REM sleep may be a major correlate of RSWA. There was a positive correlation between the total duration of REMs and the mean durations of RSWA. The REMs index demonstrated moderate sensitivity and specificity in the diagnosis of RSWA.
Article
Pediatrics
Thomas J. Dye, Narong Simakajornboon
Summary: Narcolepsy is a lifelong sleep disorder with two distinct subtypes. The pathogenesis involves both genetic and environmental factors, as well as potential autoimmune processes. Diagnosis in children may be challenging due to atypical presentation and limitations in testing.
PEDIATRIC PULMONOLOGY
(2022)
Review
Neurosciences
Vishal Chavda, Bipin Chaurasia, Giuseppe E. Umana, Santino Ottavio Tomasi, Bingwei Lu, Nicola Montemurro
Summary: Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness and brief involuntary sleep episodes. The exact pathophysiology is unknown and differential diagnosis can be challenging. Treatment should be tailored to the patient's symptoms and clinical diagnosis.
Article
Clinical Neurology
Claudio L. A. Bassetti, Ulf Kallweit, Luca Vignatelli, Giuseppe Plazzi, Michel Lecendreux, Elisa Baldin, Leja Dolenc-Groselj, Poul Jennum, Ramin Khatami, Mauro Manconi, Geert Mayer, Markku Partinen, Thomas Pollmaecher, Paul Reading, Joan Santamaria, Karel Sonka, Yves Dauvilliers, Gert J. Lammers
Summary: This paper provides evidence-based guidelines for the management of narcolepsy in adults and children, with main recommendations focusing on treatment options for excessive daytime sleepiness and cataplexy, tailored to each patient's individual circumstances.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Regis Lopez, Lucie Barateau, Anna Laura Rassu, Elisa Evangelista, Sofiene Chenini, Sabine Scholz, Isabelle Jaussent, Yves Dauvilliers
Summary: The study aims to evaluate alternative measures of the multiple sleep latency test (MSLT) for identifying hypocretin-deficiency in patients with hypersomnolence, including narcolepsy patients. The results show that compared to the current neurophysiological standard criteria, alternative MSLT measures are more effective in identifying hypocretin-deficient patients with hypersomnolence and narcolepsy. Daytime REM sleep duration is highlighted as a relevant neurophysiological biomarker of hypocretin-deficiency, which can be used in clinical and research settings.
Article
Clinical Neurology
Demet Aygun, F. Inci Ertas, Aysegul Gunduz, Gulcin Benbir Senel, Derya Karadeniz, Meral Kiziltan
Summary: The prepulse modulation was abnormal in both iRBD and RSWA, while ASR was enhanced in iRBD. This suggests certain similarities and differences in the pathophysiologies of iRBD and RSWA.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Anita D'Anselmo, Sergio Agnoli, Marco Filardi, Fabio Pizza, Serena Mastria, Giovanni Emanuele Corazza, Giuseppe Plazzi
Summary: The study explored psychological distress associated with COVID-19 restrictions and its relationship with depressive symptoms and creativity in patients with narcolepsy type 1 (NT1). Results showed that patients with NT1 experienced improvements in subjective sleepiness while controls reported worsening sleep quality during the lockdown. Depression and NT1 symptom severity were significant predictors of COVID-19-related distress. Creative performance, particularly generative fluency, was found to reduce the detrimental effect of depression on the patients' wellbeing. In contrast, creative originality was a disadvantageous moderator in the relationship between NT1 symptom severity and distress associated with the traumatic event.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Clinical Neurology
Alessandro Musetti, Alessio Gori, Alessia Alessandra, Eleonora Topino, Grazia Terrone, Giuseppe Plazzi, Marco Cacioppo, Christian Franceschini
Summary: This study aims to explore the associations between problematic online pornographic use (POPU), psychological stress, emotion dysregulation and insomnia symptoms, and understand the mediating role of psychological stress and emotion dysregulation in the relationship between POPU and insomnia symptoms. The findings showed that higher psychological stress and emotion dysregulation fully mediated the link between POPU and insomnia symptoms.
NATURE AND SCIENCE OF SLEEP
(2022)
Editorial Material
Psychology, Multidisciplinary
Chiara Baglioni, Luigi De Gennaro, Dieter Riemann, Dagmara Dimitriou, Christian Franceschini
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Clinical Neurology
Giorgia Varallo, Luca Pingani, Alessandro Musetti, Gian Maria Galeazzi, Fabio Pizza, Gianluca Castelnuovo, Giuseppe Plazzi, Christian Franceschini
Summary: This study aimed to describe how narcolepsy is portrayed in newspapers. The findings showed that there is a certain degree of stigmatization and stereotyping in the media portrayal of narcolepsy. The results provide guidance for improving how narcolepsy is depicted in the media and can inform the development of targeted anti-stigma campaigns.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Review
Clinical Neurology
Giorgia Varallo, Emanuele M. Giusti, Chiara Manna, Gianluca Castelnuovo, Fabio Pizza, Christian Franceschini, Giuseppe Plazzi
Summary: This systematic review and meta-analysis found that sleep disturbances and disorders are significantly associated with chronic postsurgical pain, but with a small effect size. The association varies in different patient groups and outcomes, possibly due to various factors. Therefore, preoperative evaluation of sleep issues is important in identifying patients at risk for chronic postsurgical pain.
SLEEP MEDICINE REVIEWS
(2022)
Article
Psychology, Applied
Andrea Ballesio, Andrea Zagaria, Alessandro Musetti, Vittorio Lenzo, Laura Palagini, Maria Catena Quattropani, Elena Vegni, Federica Bonazza, Maria Filosa, Tommaso Manari, Maria Francesca Freda, Emanuela Saita, Gianluca Castelnuovo, Giuseppe Plazzi, Caterina Lombardo, Christian Franceschini
Summary: The psychological consequences of the COVID-19 pandemic may result in increased stress and sleep disturbances. This study provides longitudinal evidence for the effects of perceived stress on sleep disturbances during the pandemic.
Article
Clinical Neurology
Zhongxing Zhang, Yves Dauvilliers, Giuseppe Plazzi, Geert Mayer, Gert Jan Lammers, Joan Santamaria, Markku Partinen, Sebastiaan Overeem, Rafael del Rio Villegas, Karel Sonka, Rosa Peraita-Adrados, Raphael Heinzer, Aleksandra Wierzbicka, Birgit Hogl, Mauro Manconi, Eva Feketeova, Antonio Martins da ilva, Jitka Buskova, Claudio LA Bassetti, Lucie Barateau, Fabio Pizza, Elena Antelmi, Jari K. Gool, Rolf Fronczek, Carles Garg, Ramin Khatami
Summary: This study on NT1 patients in Europe found significant differences in diagnostic delay among countries, with factors such as age at cataplexy onset, interval between EDS and cataplexy onsets, and cataplexy frequency being associated with longer delay.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Medicine, General & Internal
Giorgia Varallo, Paolo Pitera, Jacopo Maria Fontana, Michele Gobbi, Marco Arreghini, Emanuele Maria Giusti, Christian Franceschini, Giuseppe Plazzi, Gianluca Castelnuovo, Paolo Capodaglio
Summary: This study aimed to evaluate the effects of adding WBC intervention to a multidisciplinary rehabilitation program for FM patients with obesity. The results showed that the group that underwent WBC intervention had greater improvements in pain severity, depressive symptoms, disease impact, and sleep quality. However, no significant differences were found in performance-based physical functioning between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Education, Special
Marco Veneruso, Giorgia Varallo, Christian Franceschini, Anna Mercante, Martina Rossetti, Alessandro Rebuttini, Alessia Mantovani, Alessandro Musetti, Gianluca Castelnuovo, Lino Nobili, Franco Nardocci, Giuseppe Plazzi
Summary: This study demonstrates that a culinary group intervention can improve daily living skills and reduce symptom severity in adolescents and young adults with autism spectrum disorder (ASD). Therefore, the development of culinary laboratories could be beneficial for interventions targeting this population.
RESEARCH IN DEVELOPMENTAL DISABILITIES
(2022)
Article
Health Care Sciences & Services
Alberto Sardella, Vittorio Lenzo, Giorgio Basile, Alessandro Musetti, Christian Franceschini, Maria C. Quattropani
Summary: The study aimed to explore gender and sociodemographic differences in psychological resilience in older adults during the COVID-19 lockdown in Italy. Results showed that older women had lower resilience scores compared to men, and older adults in relationships or with children had higher resilience scores. Additionally, lower resilience scores were associated with higher levels of stress, anxiety, and depression.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Giorgia Andrini, Gian Maria Asioli, Luca Spinardi, Roberto D'Angelo
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Andrea Zagaria, Scarpelli Serena, Alessandro Musetti, Giada Rapelli, Luigi De Gennaro, Giuseppe Plazzi, Christian Franceschini
Summary: This study investigated changes in sleep problems during the COVID-19 pandemic and found a link between sleep hygiene practices and sleep disruptions. Improving sleep hygiene practices may help mitigate the negative impact of the COVID-19 pandemic on sleep.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Health Care Sciences & Services
Giorgia Varallo, Alessandro Musetti, Anita D'Anselmo, Alessio Gori, Emanuele Maria Giusti, Fabio Pizza, Gianluca Castelnuovo, Giuseppe Plazzi, Christian Franceschini
Summary: This study compared levels of problematic online gaming, problematic social media use, and compulsive Internet use between narcolepsy type 1 (NT1) patients and healthy controls (HC) for the first time, and found that NT1 patients had higher levels of problematic online gaming. Emotion dysregulation may be an intervention target for reducing compulsive Internet use and problematic social media use.
Article
Health Care Sciences & Services
Alessandro Musetti, Valentina Grazia, Alessia Alessandra, Christian Franceschini, Paola Corsano, Claudia Marino
Summary: Research has shown an association between vulnerable narcissism and problematic social networking site use, with motives mediating this relationship. Individuals with vulnerable narcissism may develop problematic social networking site use as a strategy to satisfy their needs.
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)