Article
Biochemistry & Molecular Biology
Maximiliano Elgueta-Reyes, Victoria B. Velasquez, Pedro Espinosa, Raul Riquelme, Tatiana Dib, Nicole K. Sanguinetti, Angelica P. Escobar, Jonathan Martinez-Pinto, Georgina M. Renard, Ramon Sotomayor-Zarate
Summary: Early life exposure to sex hormones has long-lasting effects on brain areas involved in regulating locomotor and motivation behaviors. This study demonstrates that neonatal exposure to sex hormones alters the brain dopamine system and affects behavioral and neurochemical responses to amphetamine and methylphenidate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Hiroki Kawashima, Yuri Aono, Yuriko Watanabe, John L. Waddington, Tadashi Saigusa
Summary: This study demonstrates that accumbal OX2 receptors, not OX1 receptors, inhibit basal dopamine efflux, while blocking OX2 receptors increases dopamine efflux. OX1 receptors have no effect on dopamine efflux.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Klara Danielsson, Oona Lagstrom, Mia Ericson, Bo Soderpalm, Louise Adermark
Summary: The study suggests that repeated amphetamine exposure leads to selective effects on dopamine signaling in striatal subregions, explaining why tolerance develops towards the drug's rewarding effects but not its psychosis inducing properties.
Article
Anatomy & Morphology
Imre Kallo, Azar Omrani, Frank J. Meye, Han de Jong, Zsolt Liposits, Roger A. H. Adan
Summary: Orexin neurons play a role in homeostatic regulatory processes and provide input to VTA, a central hub processing reward and motivation. This study found that the VTA neurons projecting to the mNAcs receive more input from orexin neurons compared to those projecting to the mPFC. Orexin exerts facilitatory effects on both clusters of dopamine neurons.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Shuai Wang, Ming Li, Linlan Su, Yu Wang, Dongliang Ma, Hongyan Wang, Jie Zhu, Teng Chen
Summary: Distinct changes in dopaminergic and glutamatergic synapses and cells were observed in the nucleus accumbens shell (NAcsh) of METH-sensitized mice. The knockout of dopamine D3 receptor gene blocked these changes and may contribute, at least partially, to METH-induced behavioral sensitization and the modulating effect of the dopamine D3 receptor.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Juan Zegers-Delgado, Camila Blanlot, Florencia Calderon, Hector E. Yarur, Javier Novoa, Ignacio Vega-Quiroga, Cristian P. Bastias, Katia Gysling
Summary: The increase of dopamine in the reward system is related to the reinforcing effects of drugs of abuse and hyper locomotion induced by psychostimulants. This study evaluates the relationship between ROS and amphetamine. The results demonstrate that pretreatment with a ROS scavenger attenuates the locomotion and oxidative stress induced by amphetamine, and also reduces dopamine increase and DAT phosphorylation.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Aske L. Ejdrup, Joel Wellbourne-Wood, Jakob K. Dreyer, Nina Guldhammer, Matthew D. Lycas, Ulrik Gether, Benjamin J. Hall, Gunnar Sorensen
Summary: A fundamental concept in neuroscience is the transmission of information between neurons via neurotransmitters, modulators, and peptides. The gold standard for measuring neurochemicals in awake animals has been microdialysis (MD), but genetically encoded fluorescence-based biosensors and in vivo optical techniques have introduced technologically distinct means of measuring neurotransmission. Comparing MD and fiber photometry (FP), the study found that although there were temporal differences, the readouts of extracellular dopamine (DA) correlated well within mice. Down-sampling of FP data showed temporal correlation to MD, with less variance observed using FP. The study also discovered periodic low levels of DA fluctuations and rapid predrug DA dynamics measured with FP that correlated to the subsequent pharmacodynamics of amphetamine as measured with MD and FP.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Wen Ting Cai, Wha Young Kim, Myung Ji Kwak, Haeun Rim, Seung Eun Lee, Lars Bjorn Riecken, Helen Morrison, Jeong-Hoon Kim
Summary: Repeated injections of psychomotor stimulants can induce behavioral sensitization and lead to addictive behaviors. This study found that a specific mutant can inhibit the development of sensitization, providing important clues for understanding the role of dendritic spines in psychomotor stimulant addiction.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Behavioral Sciences
Julia Schuller, Michael Koch
Summary: Impulsivity is associated with psychiatric diseases, and impulse control involves several brain regions. This study investigated the role of OX and CART in impulse control in rats, and found that OX is dependent on underlying impulsivity while CART is independent of trait impulsivity.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Angelica P. Escobar, Jonathan Martinez-Pinto, Francisco Silva-Olivares, Ramon Sotomayor-Zarate, Pablo R. Moya
Summary: EAAT3 overexpression impacts dopamine transmission, making dopamine neurons more sensitive to the effects of amphetamine and leading to an imbalance between the direct and indirect striatal pathways that favors the performance of repetitive behaviors.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Saeedeh Nasrollahi, Sara Karimi, Gholamali Hamidi, Monireh Naderitehrani, Alireza Abed
Summary: This study explored the interaction of olanzapine (OLZ) with the orexinergic receptor 1 in the AcbS on effort-related high reward choice. The results showed that OLZ administration in the AcbS altered rat's preference for high reward, while blocking of the OX1R could reverse the effect of OLZ. In contrast, administration of the OX1R antagonist alone led to a decrease in rat's preference for high reward, suggesting that orexin-1 antagonist may affect the effects of antipsychotic drugs.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
J. Daniel Obray, Christina A. Small, Emily K. Baldwin, Eun Young Jang, Jin Gyeom Lee, Chae Ha Yang, Jordan T. Yorgason, Scott C. Steffensen
Summary: This study found that peripherally administered dopamine can enhance dopamine levels in the nucleus accumbens and modulate related behaviors. Dopamine subtype-2 receptors are involved in this process and can influence dopamine neuron activity.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Muhammad O. Chohan, Hannah Yueh, Halli Fein, Jared M. Kopelman, Susanne E. Ahmari, Jeremy Veenstra-VanderWeele
Summary: Repeated amphetamine use leads to locomotor sensitization, which may be related to the development of psychosis and addiction. The interaction between dopaminergic and glutamatergic systems plays a significant role in amphetamine sensitization. However, the impact of chronic alterations in the expression of the excitatory amino acid transporter (EAAT3) on this phenomenon is still uncertain.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Gleice Kelli Silva-Cardoso, Manoel Jorge Nobre
Summary: Ketamine is a drug that can be abused for its reinforcing properties and can induce tolerance through Pavlovian conditioning in specific environmental contexts. Research shows that ketamine can induce short-term and pharmacological conditioned tolerance, affecting dopamine and serotonin release, with potential implications in specific environments.
NEUROCHEMICAL RESEARCH
(2021)
Article
Cell Biology
Wenjie Zou, Zhipeng Guo, Longge Suo, Jianping Zhu, Haiyang He, Xiufeng Li, Kewan Wang, Rongqing Chen
Summary: The study revealed that the NAc shell and its D1R-MSN or D2R-MSN play crucial roles in the propagation and generalization of TLE seizures. Pharmacological or cell-type-specific chemogenetic inhibition of the NAc shell can alleviate TLE seizures by reducing the number of generalized seizures.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemical Research Methods
Anand Joshi, Brian Parris, Yongzhen Liu, Christian Heidbreder, Phillip M. Gerk, Matthew Halquist
BIOMEDICAL CHROMATOGRAPHY
(2017)
Article
Pharmacology & Pharmacy
Anand Joshi, Matthew Halquist, Zacharoula Konsoula, Yongzhen Liu, J. P. Jones, Christian Heidbreder, Phillip M. Gerk
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2017)
Article
Medicine, Research & Experimental
Walter Ling, Vijay R. Nadipelli, Naoko A. Ronquest, Victoria A. Albright, Arnie P. Aldridge, Susan M. Learned, Vishaal Mehrad, Christian Heidbreder
CONTEMPORARY CLINICAL TRIALS
(2019)
Article
Substance Abuse
Walter Ling, Vijay R. Nadipelli, Caitlyn T. Solem, Naoko A. Ronquest, Yu-Chen Yeh, Susan M. Learned, Vishaal Mehra, Christian Heidbreder
JOURNAL OF ADDICTION MEDICINE
(2019)
Article
Medicine, General & Internal
Barbara R. Haight, Susan M. Learned, Celine M. Laffont, Paul J. Fudala, Yue Zhao, Amanda S. Garofalo, Mark K. Greenwald, Vijay R. Nadipelli, Walter Ling, Christian Heidbreder, James L. Andersen, Genie L. Bailey, Scott Robert Bartley, Michael J. Biunno, Brent Boyett, Jesse M. Carr, Eduardo Cifuentes, Sandra Daniela Duarte-Sckell, Otto R. Dueno, Boyde J. Harrison, David R. Hassman, Kent Steven Hoffman, Valentin Isacesu, Saleem Ishaque, Rishi Kakar, Kyle Kampman, Richard D. Knapp, George Konis, Jelena Kunovac, Joseph A. Kwentus, Lawrence S. Levinson, Shishuka Malhotra, Vishaal Mehra, Ricky Stuart Mofsen, Marvin Lane Peyton, Gita G. Pujari, Rakesh Ranjan, Daniel Rutrick, Gregory Seal, Scott Daniel Segal, Rajinder Shiwach, Haydn Mikel Thomas, Peter Paul Ventre, Amit K. Vijapura, David P. Walling, Katharina L. Wiest
Article
Pharmacology & Pharmacy
Anne Andorn, Jay Graham, John Csernansky, John W. Newcomer, Sunita Shinde, Gilbert Muma, Christian Heidbreder, Maurizio Fava
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2019)
Article
Medicine, General & Internal
Rahul Dhanda, Della Varghese, Vijay R. Nadipelli, Maurizio Fava, Namita Joshi, Caitlyn T. Solem, James A. Graham, Susan M. Learned, Christian Heidbreder
PATIENT PREFERENCE AND ADHERENCE
(2019)
Article
Substance Abuse
Walter Ling, Vijay R. Nadipelli, Arnie P. Aldridge, Naoko A. Ronquest, Caitlyn T. Solem, Howard Chilcoat, Victoria Albright, Courtney Johnson, Susan M. Learned, Vishaal Mehra, Christian Heidbreder
JOURNAL OF ADDICTION MEDICINE
(2020)
Article
Substance Abuse
Brent Boyett, Katharina Wiest, Lori D. McLeod, Lauren M. Nelson, Warren K. Bickel, Susan M. Learned, Christian Heidbreder, Paul J. Fudala, Anne Le Moigne, Yue Zhao
Summary: The psychometric evaluation of the OC-VAS on a large OUD patient population provides evidence supporting its use in measuring the severity of opioid craving and predicting opioid use.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Pharmacology & Pharmacy
Celine M. Laffont, Eliford Ngaimisi, Mathangi Gopalakrishnan, Vijay Ivaturi, Malcolm Young, Mark K. Greenwald, Christian Heidbreder
Summary: This study analyzes the relationship between buprenorphine plasma exposure and clinical efficacy in individuals with opioid use disorder (OUD). The findings suggest that maintaining buprenorphine plasma concentrations at 2-3 ng/ml optimizes treatment outcomes in most patients, while certain subgroups may require higher concentrations. The study also identifies demographic, genetic, and social factors that modulate treatment response and retention.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Substance Abuse
Christian Heidbreder, Paul J. Fudala, Mark K. Greenwald
Summary: This article reviews the discovery and early development stages of buprenorphine, the key steps that led to its approval as a drug product, and the regulatory approval of several buprenorphine-based medications for the treatment of opioid use disorder. The article discusses the progressive improvements in availability and efficacy of opioid use disorder treatment through regulatory and policy evolution, while also highlighting the challenges that still exist in improving treatment quality, integrating treatment into routine care and reducing disparities in access to treatment.
DRUG AND ALCOHOL DEPENDENCE REPORTS
(2023)
Article
Pharmacology & Pharmacy
Anne C. Andorn, Barbara R. Haight, Sunita Shinde, Paul J. Fudala, Yue Zhao, Christian Heidbreder, Susan M. Learned, Norma Lynn Fox, Vijay R. Nadipelli, David Hassman, Daniel Rutrick
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2020)
Article
Psychology, Clinical
Walter Ling, Vijay R. Nadipelli, Caitlyn T. Solem, Naoko A. Ronquest, Yu-Chen Yeh, Susan M. Learned, Vishaal Mehra, Christian Heidbreder
JOURNAL OF SUBSTANCE ABUSE TREATMENT
(2020)
Article
Substance Abuse
Walter Ling, Vijay R. Nadipelli, Caitlyn T. Solem, David Farabee, Naoko A. Ronquest, Brian Perrochet, Susan M. Learned, Chinmay G. Deshpande, Christian Heidbreder
SUBSTANCE ABUSE AND REHABILITATION
(2019)
Article
Pharmacology & Pharmacy
Vijay Ivaturi, Mathangi Gopalakrishnan, Jogarao V. S. Gobburu, Weiyan Zhang, Yongzhen Liu, Christian Heidbreder, Celine M. Laffont
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)