The Life and Death of Epithelia During Inflammation: Lessons Learned from the Gut

Cytoskeletal Regulation of Epithelial Barrier Function During Inflammation

(2010) Andrei I. Ivanov et al.   AMERICAN JOURNAL OF PATHOLOGY

Epithelial repair mechanisms in the lung

(2010) Lynn M. Crosby et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

(2010) Vincent F. Taelman et al.   CELL

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling

(2010) Gabrielle H. Ashton et al.   DEVELOPMENTAL CELL

Loss of Indian Hedgehog Activates Multiple Aspects of a Wound Healing Response in the Mouse Intestine

(2010) Willemijn A. van Dop et al.   GASTROENTEROLOGY

Phosphoinositide 3-Kinase Signaling Mediates β-Catenin Activation in Intestinal Epithelial Stem and Progenitor Cells in Colitis

(2010) Goo Lee et al.   GASTROENTEROLOGY

Distinct Effects of p38α Deletion in Myeloid Lineage and Gut Epithelia in Mouse Models of Inflammatory Bowel Disease

(2010) Motoyuki Otsuka et al.   GASTROENTEROLOGY

Interferon-γ Regulates Intestinal Epithelial Homeostasis through Converging β-Catenin Signaling Pathways

(2010) Porfirio Nava et al.   IMMUNITY

Expression profiling of Wnt family of genes in normal and inflammatory bowel disease primary human intestinal myofibroblasts and normal human colonic crypt epithelial cells

(2010) K. R. Hughes et al.   INFLAMMATORY BOWEL DISEASES

The overexpression of the putative gut stem cell marker Musashi-1 induces tumorigenesis through Wnt and Notch activation

(2010) A. Rezza et al.   JOURNAL OF CELL SCIENCE

Th17 Cytokines and the Gut Mucosal Barrier

(2010) Christoph Blaschitz et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Nuclear IKKβ Is an Adaptor Protein for IκBα Ubiquitination and Degradation in UV-Induced NF-κB Activation

(2010) Yoshihiro Tsuchiya et al.   MOLECULAR CELL

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation

(2010) Clare C. Davies et al.   NATURE CELL BIOLOGY

Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists

(2010) Neil Dufton et al.   PHARMACOLOGY & THERAPEUTICS

Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification

(2010) E. L. Campbell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells

(2010) R. K. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coexistence of Quiescent and Active Adult Stem Cells in Mammals

(2010) L. Li et al.   SCIENCE

Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors

(2010) Johan H. van Es et al.   Nature Communications

Epithelial NF-κB Enhances Transmucosal Fluid Movement by Altering Tight Junction Protein Composition after T Cell Activation

(2009) Yueming Tang et al.   AMERICAN JOURNAL OF PATHOLOGY

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Lipocalin-2 Resistance Confers an Advantage to Salmonella enterica Serotype Typhimurium for Growth and Survival in the Inflamed Intestine

(2009) Manuela Raffatellu et al.   Cell Host & Microbe

The stem cells of small intestinal crypts: where are they?

(2009) C. S. Potten et al.   CELL PROLIFERATION

Intestinal Stem Cells in Mammals and Drosophila

(2009) Andreu Casali et al.   Cell Stem Cell

The effects of mechanical forces on intestinal physiology and pathology

(2009) Christopher P. Gayer et al.   CELLULAR SIGNALLING

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Proposal of a New Hypothesis on the Development of Colorectal Epithelial Neoplasia: Nonspecific Inflammation – Colorectal Paneth Cell Metaplasia – Colorectal Epithelial Neoplasia

(2009) Ryo Wada   DIGESTION

JNK signalling modulates intestinal homeostasis and tumourigenesis in mice

(2009) Rocio Sancho et al.   EMBO JOURNAL

The Multifaceted Influence of the Mucosal Microflora on Mucosal Dendritic Cell Responses

(2009) Warren Strober   IMMUNITY

Immune Responses to the Microbiota at the Intestinal Mucosal Surface

(2009) Breck A. Duerkop et al.   IMMUNITY

Phosphatidylinositol 3-Kinase Signaling Does Not Activate the Wnt Cascade

(2009) Ser Sue Ng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Defensins in Enteric Innate Immunity

(2009) Jennifer R. Mastroianni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Cross-talk between β-Catenin and NFκB Signaling Pathways in Colonic Crypts of Mice in Response to Progastrin

(2009) Shahid Umar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis

(2009) S. Inoue et al.   JOURNAL OF IMMUNOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

(2009) Akifumi Ootani et al.   NATURE MEDICINE

Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer

(2009) Linda A. Feagins et al.   Nature Reviews Gastroenterology & Hepatology

Epidermal homeostasis: a balancing act of stem cells in the skin

(2009) Cédric Blanpain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GSK3β Is Involved in JNK2-Mediated β-Catenin Inhibition

(2009) Dong Hu et al.   PLoS One

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer

(2009) V. Rodilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

(2009) S. Fre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Stromal Stem Cells in Tissue Regeneration and Wound Repair

(2009) T. S. Stappenbeck et al.   SCIENCE

The keratinocyte in epidermal renewal and defence

(2009) Maja M. Suter et al.   VETERINARY DERMATOLOGY

c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/ -catenin signaling through GSK3  pathway

(2008) D. Hu et al.   CARCINOGENESIS

Activated macrophages promote Wnt signalling through tumour necrosis factor-α in gastric tumour cells

(2008) Keisuke Oguma et al.   EMBO JOURNAL

Raf Protects Against Colitis by Promoting Mouse Colon Epithelial Cell Survival Through NF-κB

(2008) Karen L. Edelblum et al.   GASTROENTEROLOGY

Current View: Intestinal Stem Cells and Signaling

(2008) David H. Scoville et al.   GASTROENTEROLOGY

Interleukin-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice

(2008) X. Jin et al.   GUT

The role of the novel Th17 cytokine IL-26 in intestinal inflammation

(2008) J Dambacher et al.   GUT

Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohnʼs disease

(2008) John P. Burke et al.   INFLAMMATORY BOWEL DISEASES

Constitutive Expression of IL-18 and IL-18R in Differentiated IEC-6 Cells: Effect of TNF-α and IFN-γ Treatment

(2008) Jirina Kolinska et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Efficient colonic mucosal wound repair requires Trem2 signaling

(2008) H. Seno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3  Inactivation

(2008) T. M. Thornton et al.   SCIENCE

Role of the JNK signal transduction pathway in inflammatory bowel disease

(2008) Praveen K Roy et al.   WORLD JOURNAL OF GASTROENTEROLOGY