Article
Biochemistry & Molecular Biology
Toyoshi Yanagihara, Kazuya Tsubouchi, Mahsa Gholiof, Sy Giin Chong, Kenneth E. Lipson, Quan Zhou, Ciaran Scallan, Chandak Upagupta, Jussi Tikkanen, Shaf Keshavjee, Kjetil Ask, Martin R. J. Kolb
Summary: Idiopathic pulmonary fibrosis is a fatal lung disease characterized by the accumulation of myofibroblasts. The study found that connective-tissue growth factor (CTGF) plays a key role in pulmonary fibrosis. Increased levels of CTGF exacerbate lung fibrosis and CTGF expression is upregulated in patients with idiopathic pulmonary fibrosis. Different cells contribute to the maintenance of the fibrotic phenotype during fibrogenesis.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Rong Liu, Min Zhu, Jiaojiao Chen, Junwei Gai, Jing Huang, Yingqun Zhou, Yakun Wan, Chuantao Tu
Summary: In this study, a novel nanobody (Nb) against human connective tissue growth factor (CTGF) was identified, which showed antifibrotic effects in vitro by regulating the biological functions of human stellate cells. This study is of great importance for the development of antifibrotic therapies for liver fibrosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Respiratory System
Dymph Klay, Joanne J. van der Vis, Suzan M. Roothaan, Tri Q. Nguyen, Jan C. Grutters, Roel Goldschmeding, Coline H. M. van Moorsel
Summary: CTGF rs6918698G is associated with spIPF and FPF, but not with CTD-ILD in a Dutch cohort. Localization of CTGF in lung tissue suggests its involvement in IPF pathogenesis.
Article
Medicine, General & Internal
Puneeta Arya, Sjirk J. Westra, Oscar J. Benavidez, Marc D. Natter, Mandakolathur R. Murali
Summary: This passage describes the case of a 17-year-old boy who was admitted to the ICU with chest pain. He had developed symptoms such as fever, nausea, diarrhea, muscle aches, and chest pain 5 days prior.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Xiaoqi Nie, Qianqian Yu, Long Li, Minxiao Yi, Bili Wu, Yongbiao Huang, Yonghui Zhang, Hu Han, Xianglin Yuan
Summary: Kinsenoside alleviates radiation-induced liver fibrosis by regulating the TGF-beta 1/Smad/CTGF pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Yanqin Zhang, Xiangyu Chang, Di Wu, Mengqi Deng, Jinwei Miao, Zhaoyu Jin
Summary: Exosomal miR-214-3p can inhibit fibrosis in endometriosis by targeting CCN2, providing a potential therapeutic approach for EMs.
REPRODUCTIVE SCIENCES
(2021)
Article
Rheumatology
Goncalo Boleto, Silje Reiseter, Anna-Maria Hoffmann-Vold, Adrien Mirouse, Patrice Cacoub, Marco Matucci-Cerinic, Manuel Silverio-Antonio, Joao Eurico Fonseca, Ana Catarina Duarte, Jorge Pestana Lopes, Valeria Riccieri, Alain Lescoat, Erwan Le Tallec, Ivan Castellvi Barranco, Jose Luis Tandaipan, Paolo Airo, Masataka Kuwana, Hoda Kavosi, Jerome Avouac, Yannick Allanore
Summary: This study compared predictive factors for interstitial lung disease (ILD) in patients with mixed connective tissue disease (MTCD) and found different factors associated with ILD. The study also found that MCTD-ILD patients have increased mortality and that digital ulcers (DU) are associated with progressive lung disease.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Respiratory System
Noriyuki Enomoto, Sakae Homma, Naohiko Inase, Yasuhiro Kondoh, Takeshi Saraya, Hajime Takizawa, Yoshikazu Inoue, Hiroshi Ishii, Yoshio Taguchi, Shinyu Izumi, Yasuhiko Yamano, Yoshinori Tanino, Yasuhiko Nishioka, Mikio Toyoshima, Koshi Yokomura, Shiro Imokawa, Naoki Koshimizu, Takehisa Sano, Taisuke Akamatsu, Hiroshi Mukae, Motoyasu Kato, Naoki Hamada, Hirofumi Chiba, Shinobu Akagawa, Shigeo Muro, Hironori Uruga, Hiroyuki Matsuda, Yusuke Kaida, Miho Kanai, Kazutaka Mori, Masafumi Masuda, Hironao Hozumi, Tomoyuki Fujisawa, Yutaro Nakamura, Noriyoshi Ogawa, Takafumi Suda
Summary: This nationwide multicentre study prospectively evaluated 376 patients with IIP, finding that 18.6% of them met the IPAF criteria. Patients with IPAF were more likely to develop systemic autoimmune diseases, had fewer acute exacerbations of IIP, and showed better survival outcomes. Cluster analysis identified a subgroup with more autoimmune features, predominantly female, and with a better prognosis.
Article
Biochemistry & Molecular Biology
Si-Min Zhang, Chuan-Yuan Wei, Qiang Wang, Lu Wang, Lu Lu, Fa-Zhi Qi
Summary: Our research showed for the first time that M2 promotes wound healing by secreting CTGF, which further mediates the proliferation and migration of fibroblasts via the AKT, ERK1/2, and STAT3 pathways.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Immunology
Shanshan Xiong, Jinyu Tan, Yu Wang, Jinshen He, Fan Hu, Xiaomin Wu, Zishan Liu, Sinan Lin, Xuehua Li, Zhihui Chen, Ren Mao
Summary: This article summarizes the possible mechanisms of creeping fat fibrosis and its impact on other diseases. It illustrates the role of different cells and molecules in the pathogenesis of fat fibrosis in other diseases to understand the role of creeping fat fibrosis in Crohn's disease pathogenesis. Future research will provide key information on the role of fat fibrosis in creeping fat formation and intestinal damage, helping to identify novel targets for the diagnosis and treatment of Crohn's disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Takuya Kotani, Masaki Ikemoto, Shogo Matsuda, Ryota Masutani, Tohru Takeuchi
Summary: In this study, it was found that the hybrid protein hMIKO-1 can suppress the abnormal activation of macrophages, reduce lung fibrosis in mice, and decrease the expression of related inflammation factors, indicating its potential as a therapeutic candidate for ILD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Xiaozheng Song, Yuqiang Cui, Teng Zhu
Summary: The study aimed to verify the effects of miR-19 on cardiac fibrosis and its target. The expression of miR-19 was reduced in the heart tissue and cardiac fibroblasts. Upregulating miR-19 can improve cardiac function and attenuate cardiac fibrosis by inhibiting the CTGF and MAPK pathways.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Cell Biology
Zihang Yuan, Jie Wang, Haoran Zhang, Yuanyuan Chai, Yunxia Xu, Yingying Miao, Ziqiao Yuan, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu
Summary: This study found that bile acids, particularly glycocholic acid (GCA), can induce the expression of connective tissue growth factor in hepatocytes by promoting the nuclear translocation of yes-associated protein, thereby activating hepatic stellate cells and promoting the progression of liver fibrosis in cholestatic disease.
CELLULAR SIGNALLING
(2023)
Article
Multidisciplinary Sciences
Peng Wang, Zhitao Huang, Yili Peng, Hongwei Li, Tong Lin, Yingyu Zhao, Zheng Hu, Zhanmei Zhou, Weijie Zhou, Youhua Liu, Fan Fan Hou
Summary: This study identifies a circular RNA called circBNC2, which inhibits G2/M arrest of epithelial cells to prevent fibrosis in damaged kidney and liver, providing a potential target for intervention in fibrosis.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Medicinal
Yuecheng Jiang, Xin Lin, Yan Mao, Jianqiu Zhao, Guihua Zhang, Jiali Yu, Rong Dong, Yan Zha
Summary: The study found that acteoside (ACT) can inhibit renal fibrosis in unilateral ureteral obstruction (UUO) rats, probably by inhibiting the beta-catenin/CTGF signaling pathway.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Padhmanand Sudhakar, Judith Wellens, Bram Verstockt, Marc Ferrante, Joao Sabino, Severine Vermeire
Summary: Inflammatory bowel disease (IBD) is a global disease that affects the gastrointestinal tract and also has an impact on the mental and emotional well-being of patients. Despite medical advancements, only a third of diagnosed patients achieve short to medium-term remission. Therefore, some patients might resort to complementary and alternative approaches to manage their symptoms. This study reviews the efficacy of these approaches and proposes a patient-centric clinical care model and recommendations.
Letter
Gastroenterology & Hepatology
Lucas Wauters, Raul Y. Tito, Matthias Ceulemans, An Outtier, Leen Rymenans, Chloe Verspecht, Joao Sabino, Marc Ferrante, Severine Vermeire, Tim Vanuytsel, Jeroen Raes
Article
Gastroenterology & Hepatology
Edward V. Loftus, Severine Vermeire, Brian G. Feagan, Franck-Olivier Le Brun, Alessandra Oortwijn, Ulrik Moerch, William J. Sandborn, Toshifumi Hibi
Summary: In patients with ulcerative colitis, the study found that 200 mg of filgotinib can reduce the use of corticosteroids and maintain corticosteroid-free clinical remission. Moreover, compared to other medications, filgotinib demonstrated better outcomes in patients who had not previously used biologic agents.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Elise Schoefs, Severine Vermeire, Marc Ferrante, Joao Sabino, Tessy Lambrechts, Luisa Avedano, Isabella Haaf, Maria Stella De Rocchis, Andrea Broggi, Magdalena Sajak-Szczerba, Roberto Saldana, Rosanne Janssens, Isabelle Huys
Summary: This study aimed to understand patient preferences, treatment outcomes, and unmet needs among inflammatory bowel disease (IBD) patients. The results showed that patients have various unmet needs regarding symptoms, side effects, and psychological and social issues, and they desire improved treatment outcomes. The study highlighted the importance of shared decision-making process and considering patients' preferences and uncertainties.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Edward V. Loftus, Jean-Frederic Colombel, Ken Takeuchi, Xiang Gao, Remo Panaccione, Silvio Danese, Marla Dubinsky, Stefan Schreiber, Dapo Ilo, Tricia Finney-Hayward, Wen Zhou, Charles Phillips, Yuri Sanchez Gonzalez, Lei Shu, Xuan Yao, Qing Zhou, Severine Vermeire
Summary: This study evaluated the efficacy of once-daily upadacitinib 45 mg in improving symptoms of ulcerative colitis. The analysis of pooled data from two phase 3 trials showed that upadacitinib provided rapid relief of UC symptoms from day 1, with significant improvements maintained until day 14. Patients treated with upadacitinib also achieved reductions in inflammatory markers and significant improvements in quality of life.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Zhigang Wang, Bram Verstockt, Joao Sabino, Marc Ferrante, Severine Vermeire, Erwin Dreesen
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Michele Carvello, Andre D'Hoore, Annalisa Maroli, Carlota Cuenca, Severine Vermeire, Silvio Danese, Gabriele Bislenghi, Antonino Spinelli
Summary: This retrospective study investigated the association between postoperative complications and disease recurrence in Crohn's disease patients after primary ileocolic resection. The study found that postoperative complications are independent risk factors for endoscopic recurrence, affecting the rate and timing of both endoscopic and clinical recurrence.
DISEASES OF THE COLON & RECTUM
(2023)
Review
Pharmacology & Pharmacy
Judith Wellens, Eva Vissers, Christophe Matthys, Severine Vermeire, Joao Sabino
Summary: Inflammatory bowel diseases (IBD) are chronic and incurable conditions affecting the gastrointestinal tract. Despite recent advances in medical management, many patients do not achieve remission and healing of the bowel. Personalized nutrition may be a crucial factor in achieving long-lasting changes in dietary behaviors and improving symptoms and inflammation.
PHARMACOGENOMICS & PERSONALIZED MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Bram Verstockt, Sare Verstockt, Jonathan Cremer, Joao Sabino, Marc Ferrante, Severine Vermeire, Padhmanand Sudhakar
Summary: By profiling the transcriptome of circulating monocytes and CD4 T-cells in patients with inflammatory bowel disease (IBD), potential mechanisms driving disease subtypes were inferred. The study revealed significant differences in gene expression profiles of CD4 T-cells between patients with ileal Crohn's disease (CD) and ulcerative colitis (UC), and identified specific signaling pathways and transcription factors associated with UC and CD. Additionally, novel and repurposable drug targets were discovered for both ileal CD and UC, aiding in the development of targeted therapies for IBD subtypes.
BMJ OPEN GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
William J. Sandborn, Severine Vermeire, Laurent Peyrin-Biroulet, Marla C. Dubinsky, Julian Panes, Andres Yarur, Timothy Ritter, Filip Baert, Stefan Schreiber, Sheldon Sloan, Fabio Cataldi, Kevin Shan, Christopher J. Rabbat, Michael Chiorean, Douglas C. Wolf, Bruce E. Sands, Geert D'Haens, Silvio Danese, Martina Goetsch, Brian G. Feagan
Summary: Etrasimod, a selective S1P receptor modulator, demonstrated efficacy and safety as an induction and maintenance therapy for patients with moderately to severely active ulcerative colitis. The trials showed a higher proportion of patients achieving clinical remission with Etrasimod compared to placebo at both induction and maintenance periods. This novel treatment option has the potential to address unmet needs in ulcerative colitis patients.
Review
Gastroenterology & Hepatology
S. Beysens, J. Wellens, G. De Hertogh, A. Van Laethem, J. Sabino, T. Hillary, S. Vermeire
Summary: This study conducted a retrospective case series of 11 patients with metastatic Crohn's disease (MCD). Skin biopsies showed noncaseating granulomatous inflammation in all cases. Treatment included steroids, biologicals, and surgical excision. Based on the findings and multidisciplinary discussion, a treatment algorithm for MCD was proposed.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Letter
Dermatology
Tom Hillary, Michele Grymonprez, Emma Vanhooren, Canan Guvenc, Maria Garmyn, Severine Vermeire
Summary: Venous thromboembolism is prevalent among patients with psoriasis, especially in older individuals with a history of malignancy and arterial hypertension. Dermatologists should be aware of this comorbidity and consider thromboprophylaxis in at-risk patients with psoriasis.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Bram Verstockt, Maaike Vancamelbeke, Severine Vermeire
Meeting Abstract
Gastroenterology & Hepatology
E. Schoefs, S. Vermeire, M. Ferrante, J. Sabino, B. Verstockt, L. Avedano, M. S. De Rocchis, M. Sajak-Szczerba, R. Saldana, N. Straetemans, M. Vandebroek, I. Huys, R. Janssens
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Marla C. Dubinsky, David B. Clemow, Theresa Hunter Gibble, Xingyuan Li, Severine Vermeire, Tadakazu Hisamatsu, Simon P. L. Travis
Summary: This study analyzed the efficacy of Mirikizumab in reducing bowel urgency in ulcerative colitis patients, and found that the drug is effective in improving this symptom and is associated with other clinical outcomes.
CROHNS & COLITIS 360
(2023)