Article
Chemistry, Multidisciplinary
Qing Li, Hao Luo, Fu-Qiang Dai, Ren-Tao Wang, Xiao-Qing Fan, Yuan-Yuan Luo, Meng-Sheng Deng, Yulun Wang, Tan Long, Wei Guo, Bo Xu, Cheng-Xiong Xu, Hua Jin
Summary: In this study, the authors identified SAMD9 as a predictor and promoter of postoperative recurrence in ESCC. SAMD9 activates the Wnt/β-catenin signaling pathway, enhancing tumor stemness, angiogenesis, and EMT. Silencing SAMD9 or related genes MYH9 and β-catenin can inhibit multiple malignant properties of ESCC. SAMD9 has the potential to be a predictive biomarker and crucial therapeutic target for ESCC.
Article
Biochemistry & Molecular Biology
Yao Zhang, Tingwang Shi, Yaohua He
Summary: The expression of GPR35 in bone marrow mesenchymal stem cells is suppressed in osteoporosis patients and mice, affecting osteogenic differentiation. GPR35 deficiency impairs the function of BMSCs, while overexpression contributes to osteogenesis. The synthetic GPR35 agonist zaprinast can reduce bone loss and promote bone generation, suggesting a potential novel treatment for osteoporosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Jaeyoon Kim, Jae Young Shin, Yun-Ho Choi, Nae Gyu Kang, Sanghwa Lee
Summary: The study revealed that adenosine promotes hair growth through various pathways, including stimulating the Wnt/beta-catenin pathway and activating adenosine receptor signaling to enhance cellular energy metabolism and increase the expression of growth factors.
Article
Medicine, Research & Experimental
Wenzhi Shen, Xiaoyuan Zhang, Jiaping Tang, Zhixin Zhang, Renle Du, Dehong Luo, Xiaoran Liu, Yong Xia, Yanping Li, Shanshan Wang, Siyuan Yan, Wancai Yang, Rong Xiang, Na Luo, Yunping Luo, Jianjun Li
Summary: Our study identified CCL16 as a potential regulator of cancer stem cells and proposed a novel mechanism by which CCL16 governs cancer cell stemness. We found that CCL16 overexpression in breast tumors was significantly correlated with clinical progression. Silencing CCL16 diminished CSC properties and targeting CCR2 and beta-catenin abolished CCL16-mediated cancer stemness.
Article
Biochemistry & Molecular Biology
Soeun Yang, Seohee Jung, Horim Lee
Summary: The heterotrimeric G protein subunits AGB1 and GPA1 in plants may regulate plant growth under stress conditions, with AGB1 possibly negatively regulating growth under biotic stress and GPA1 exhibiting genetically opposite effects on growth inhibition under heat stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Baisong Zhao, Yongying Pan, Haiping Xu, Xingrong Song
Summary: This study investigated the role of Wnt10a/beta-catenin signaling in kindlin-1-mediated astrocyte activation in a chronic constriction injury (CCI) neuropathic pain rat model. Results showed that inhibiting GFAP decreased kindlin-1 levels, prevented astrocyte activation, and reduced Wnt10a levels and the release of inflammatory mediators. Coimmunoprecipitation demonstrated that kindlin-1 can interact with Wnt10a. Overall, our findings suggest that kindlin-1-mediated astrocyte activation in CCI rats is associated with Wnt10a/beta-catenin signaling and the release of inflammatory mediators.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Fangming Liu, Xiaochen Gai, Yuting Wu, Baohui Zhang, Xiaoyu Wu, Rongrong Cheng, Bufu Tang, Kezhuo Shang, Na Zhao, Weiwei Deng, Jie Chen, Zhengyi Zhang, Song Gu, Liang Zheng, Hongbing Zhang
Summary: This study reveals the oncogenic role of CTNNB1 gain-of-function mutations in liver cancer development and identifies the beta-catenin/AKT2/CAD signaling cascade as a potential therapeutic target for this type of liver cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Zhenou Sun, Shutao Yin, Chong Zhao, Lihong Fan, Hongbo Hu
Summary: This study demonstrates that beta-tocotrienol (beta-T3), an isomer of vitamin E, effectively inhibits PD-L1 expression, enhances immune response, and deactivates PD-L1-induced tumor-promoting signaling, thereby exerting anticancer activity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Yuting Wu, Shuhui Yang, Luyang Han, Kezhuo Shang, Baohui Zhang, Xiaochen Gai, Weiwei Deng, Fangming Liu, Hongbing Zhang
Summary: Iron chelators selectively inhibit beta-catenin-activated cells, and stimulation of IRP2 and iron by beta-catenin enhances mitochondrial function. Depletion of IRP2-sequered iron impairs beta-catenin-invigorated mitochondrial function. The mitochondrial inhibitor S-Gboxin selectively reduces beta-catenin-associated cell viability and tumor formation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Min Xu, Yujing Hu, Yingxin Sun, Rongqiang Wu, Tongbao Feng, Ping Zhang, Min Yu
Summary: This study found that the PDE4B/Wnt/0-catenin/FoxM1 axis may be involved in CagA-induced gastric carcinogenesis and progression, suggesting that PDE4B is a promising biomarker for comprehending the underlying mechanisms of GC development.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Pharmacology & Pharmacy
Jiaqi He, Mengling Wang, Licai Yang, Hong Xin, Fan Bian, Gengru Jiang, Xuemei Zhang
Summary: This study demonstrates the therapeutic value of Astragaloside IV (AS IV) in treating intestinal dysfunction caused by long-term peritoneal dialysis (PD). AS IV protects the intestinal epithelial barrier by improving its permeability and up-regulating the expression of tight junction proteins. Additionally, AS IV activates the AKT-GSK3β-β-catenin signaling pathway to mediate its protective effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ruhi Gulati, Michael Johnston, Maria Rivas, Ashley Cast, Meenasri Kumbaji, Margaret A. Hanlon, Sanghoon Lee, Ping Zhou, Charissa Lake, Emily Schepers, Kyung-Won Min, Je-Hyun Yoon, Rebekah Karns, Lola M. Reid, Dolores Lopez-Terrada, Lubov Timchenko, Sreeja Parameswaran, Matthew T. Weirauch, Sarangarajan Ranganathan, Alexander Bondoc, James Geller, Gregory Tiao, Soona Shin, Nikolai Timchenko
Summary: This study investigates the development mechanism of fibrolamellar hepatocellular carcinoma (FLC) and identifies the role of cancer-enhancing genomic regions or aggressive liver cancer domains (CEGRs/ALCDs). It finds that beta-catenin is the driver of FLC and inhibiting beta-catenin can prevent the development of FLC.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Bo Chen, Xiaoli Li, Lihong Wu, Duanfang Zhou, Yi Song, Limei Zhang, Qiuya Wu, Qichen He, Gang Wang, Xu Liu, Hui Hu, Weiying Zhou
Summary: Quercetin significantly inhibits the viability, migration, and invasion ability of glioblastoma cells both in vitro and in vivo. This is achieved by suppressing the GSK-3 beta/beta-catenin/ZEB1 signaling pathway and reversing the EMT-like mesenchymal phenotype.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Shiyu Chen, Zhonglin Jia, Ming Cai, Mujie Ye, Dandan Wu, Teng Wan, Bowen Zhang, Peixuan Wu, Yuexin Xu, Yuntao Guo, Chan Tian, Duan Ma, Jing Ma
Summary: The study found that lncRNA ZFAS1 was significantly upregulated in NSCLP and mediated by SP1, inhibiting the WNT/β-catenin signaling pathway to affect cell proliferation, migration, and chondrogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinwu Bai, Weijun Zhang, Chenwei Zhou, Guangfeng Zhao, Huiming Zhong, Kai Hang, Jianxiang Xu, Wei Zhang, Erman Chen, Jiaqi Wu, Ling Liu, Deting Xue
Summary: MFG-E8 promotes osteogenic differentiation of BMSCs by regulating the GSK3 beta/beta-catenin signaling pathway and therefore, is a potential therapeutic target. This study has important clinical significance in addressing fracture nonunion and bone defects.
Article
Biochemistry & Molecular Biology
Rui Yang, Xiuxiu Li, Yanan Wu, Guanghui Zhang, Xiaoran Liu, Yanping Li, Yonghua Bao, Wancai Yang, Hongjuan Cui
Article
Cell Biology
Yuhua Gao, Ranxi Zhang, Guanghe Wei, Shanshan Dai, Xue Zhang, Wancai Yang, Xiangchen Li, Chunyu Bai
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2019)
Article
Oncology
Yanping Li, Ronghui Liang, Mingming Sun, Zhen Li, Hao Sheng, Jiyan Wang, Pengjuan Xu, Shuangping Liu, Wancai Yang, Bin Lu, Shuai Zhang, Changliang Shan
Article
Biochemistry & Molecular Biology
Fu-Ming Lian, Xiangwei Yang, Yong-Liang Jiang, Feng Yang, Changlin Li, Wancai Yang, Chengmin Qian
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Oncology
Wenzhi Shen, Xiaoyuan Zhang, Renle Du, Wenjuan Gao, Juan Wang, Yonghua Bao, Wancai Yang, Na Luo, Jianjun Li
BRITISH JOURNAL OF CANCER
(2020)
Article
Oncology
Rui Yang, Mei Wang, Guanghui Zhang, Yonghua Bao, Yanan Wu, Xiuxiu Li, Wancai Yang, Hongjuan Cui
BRITISH JOURNAL OF CANCER
(2020)
Article
Biochemistry & Molecular Biology
Fu-Ming Lian, Yong-Liang Jiang, Wancai Yang, Xiangwei Yang
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Endocrinology & Metabolism
Jun Wei, Wancai Yang, Zhuqing Shi, Lucy Lu, Qiang Wang, W. Kyle Resurreccion, Valentina Engelmann, S. Lilly Zheng, Peter J. Hulick, Kathleen A. Cooney, William B. Isaacs, Brian T. Helfand, Jim Lu, Jianfeng Xu
Summary: In this large population-based study, evidence for PCa risk was found for four of the 10 guideline-recommended genes: HOXB13, BRCA2, ATM, and CHEK2. Mutations in these four genes can be confidently used in genetic counseling for PCa risk assessment, while further evaluation is needed for the remaining six genes in larger studies.
Article
Endocrinology & Metabolism
Zhuqing Shi, Lucy Lu, William Kyle Resurreccion, Wancai Yang, Jun Wei, Qiang Wang, Valentina Engelmann, Siqun Lilly Zheng, Kathleen A. Cooney, William B. Isaacs, Brian T. Helfand, Jim Lu, Jianfeng Xu
Summary: The meta-analysis revealed significant associations between mutation carrier rates of genes including NBN, BRCA2, ATM, CHEK2, and PALB2 and prostate cancer progression. This provides new data for the field, but certainty of evidence remains low.
Review
Biochemistry & Molecular Biology
Lucy Lu, Adam Cole, Dan Huang, Qiang Wang, Zhongming Guo, Wancai Yang, Jim Lu
Summary: The hepsin gene is associated with prostate cancer, and its overexpression promotes cancer cell proliferation, migration, and metastasis. Increased expression of hepsin is correlated with poor prognosis for prostate cancer patients. Hepsin interacts with other oncogenic proteins, and its proteolytic activities are involved in the development of prostate cancer. Genomic amplifications of hepsin are significantly associated with prostate cancer metastasis.
Correction
Biochemistry & Molecular Biology
Rui Yang, Xiuxiu Li, Yanan Wu, Guanghui Zhang, Xiaoran Liu, Yanping Li, Yonghua Bao, Wancai Yang, Hongjuan Cui
Review
Biochemistry & Molecular Biology
Yonghua Bao, Haifeng Zhang, Zhixue Han, Yongchen Guo, Wancai Yang
Summary: This review summarizes the functions of the zinc fingers and homeobox family member ZHX and its role in cancer. ZHXs act as both tumor suppressors and oncogenes, regulating biological processes such as tumor cell proliferation, migration, invasion, and metastasis. The differential expression levels of ZHXs in different malignancies are associated with patient outcomes and their response to chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yongchen Guo, Chunna Ren, Wentao Huang, Wancai Yang, Yonghua Bao
Summary: ACSM1 is specifically elevated in prostate cancer and associated with poor prognosis and shorter survival time. Copy number alterations of ACSM1 are frequently observed in prostate cancer, but not correlated with gene expression levels. The oncogenic role of ACSM1 in prostate cancer is mainly through metabolic and ECM-receptor interaction signaling pathways, and not related to immune cell infiltration or immune subtypes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Wenzhi Shen, Xiaoyuan Zhang, Jiaping Tang, Zhixin Zhang, Renle Du, Dehong Luo, Xiaoran Liu, Yong Xia, Yanping Li, Shanshan Wang, Siyuan Yan, Wancai Yang, Rong Xiang, Na Luo, Yunping Luo, Jianjun Li
Summary: Our study identified CCL16 as a potential regulator of cancer stem cells and proposed a novel mechanism by which CCL16 governs cancer cell stemness. We found that CCL16 overexpression in breast tumors was significantly correlated with clinical progression. Silencing CCL16 diminished CSC properties and targeting CCR2 and beta-catenin abolished CCL16-mediated cancer stemness.
Article
Oncology
Junxiu Liu, Hao Tan, Wancai Yang, Shuzhong Yao, Liang Hong