The Structural Basis for Control of Eukaryotic Protein Kinases

Biological Phosphoryl-Transfer Reactions: Understanding Mechanism and Catalysis

(2011) Jonathan K. Lassila et al.   Annual Review of Biochemistry

The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling

(2011) Arvin C. Dar et al.   Annual Review of Biochemistry

A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme

(2011) Luke H. Chao et al.   CELL

Crystal Structure and Allosteric Activation of Protein Kinase C βII

(2011) Thomas A. Leonard et al.   CELL

RAF Inhibitor-Induced KSR1/B-RAF Binding and Its Effects on ERK Cascade Signaling

(2011) Melissa M. McKay et al.   CURRENT BIOLOGY

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

(2011) Maruf M U Ali et al.   EMBO JOURNAL

Biochemical, Proteomic, Structural, and Thermodynamic Characterizations of Integrin-linked Kinase (ILK)

(2011) Koichi Fukuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

(2011) Kathleen Aertgeerts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms

(2011) Natalia Jura et al.   MOLECULAR CELL

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

(2011) Damian F. Brennan et al.   NATURE

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

AMP-activated protein kinase: nature's energy sensor

(2011) David Carling et al.   Nature Chemical Biology

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling

(2011) Daniela Ungureanu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Analysis of Jak2 Catalytic Function by Peptide Microarrays: The Role of the JH2 Domain and V617F Mutation

(2011) Arturo Sanz et al.   PLoS One

Requirement for kinase-induced conformational change in eukaryotic initiation factor 2  (eIF2 ) restricts phosphorylation of Ser51

(2011) M. Dey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

(2011) J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information

(2011) M. C. Good et al.   SCIENCE

Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

(2011) J. Alexander et al.   Science Signaling

Structural Insights into the Architecture and Allostery of Full-Length AMP-Activated Protein Kinase

(2011) Li Zhu et al.   STRUCTURE

Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis

(2011) Zhao Qin Bao et al.   STRUCTURE

Phosphorylation of the Transcription Factor Ets-1 by ERK2: Rapid Dissociation of ADP and Phospho-Ets-1

(2010) Kari Callaway et al.   BIOCHEMISTRY

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Mechanistic principles of RAF kinase signaling

(2010) Christian M. Udell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protein kinase signaling networks in cancer

(2010) John Brognard et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Pseudokinases-remnants of evolution or key allosteric regulators?

(2010) Elton Zeqiraj et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Gradient of Increasing Aurora B Kinase Activity Is Required for Cells to Execute Mitosis

(2010) Zhenjie Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6

(2010) Jill E. Chrencik et al.   JOURNAL OF MOLECULAR BIOLOGY

Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface

(2010) Julie P.I. Welburn et al.   MOLECULAR CELL

The Cytoplasmic Adaptor Protein Dok7 Activates the Receptor Tyrosine Kinase MuSK via Dimerization

(2010) Elisa Bergamin et al.   MOLECULAR CELL

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

(2010) R. Luke Wiseman et al.   MOLECULAR CELL

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

(2010) Poulikos I. Poulikakos et al.   NATURE

Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation

(2010) Luke H Chao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

(2010) Fumin Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation

(2010) Peter Rellos et al.   PLOS BIOLOGY

Insights into protein kinase regulation and inhibition by large scale structural comparison

(2009) Jeyanthy Eswaran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Ste5 Scaffold Directs Mating Signaling by Catalytically Unlocking the Fus3 MAP Kinase for Activation

(2009) Matthew Good et al.   CELL

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment

(2009) Natalia Jura et al.   CELL

Her4 and Her2/neu Tyrosine Kinase Domains Dimerize and Activate in a Reconstitutedin VitroSystem

(2009) John Monsey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Intrinsic Reactivity of ATP and the Catalytic Proficiencies of Kinases Acting on Glucose,N-Acetylgalactosamine, and Homoserine

(2009) Randy B. Stockbridge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions

(2009) Koichi Fukuda et al.   MOLECULAR CELL

The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain

(2009) Monica Red Brewer et al.   MOLECULAR CELL

A dimerization-dependent mechanism drives RAF catalytic activation

(2009) Thanashan Rajakulendran et al.   NATURE

Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

(2009) Lei Chen et al.   NATURE

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

Structure and functional characterization of the atypical human kinase haspin

(2009) J. Eswaran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3

(2009) N. Jura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein kinase inhibitors: contributions from structure to clinical compounds

(2009) Louise N. Johnson   QUARTERLY REVIEWS OF BIOPHYSICS

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation

(2009) E. Zeqiraj et al.   SCIENCE

Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site

(2009) Eric D. Scheeff et al.   STRUCTURE

Structure-Based View of Epidermal Growth Factor Receptor Regulation

(2008) Kathryn M. Ferguson   Annual Review of Biophysics

Potent and selective pyrazole-based inhibitors of B-Raf kinase

(2008) Joshua D. Hansen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation

(2008) Panagis Filippakopoulos et al.   CELL

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

(2008) Kenneth P.K. Lee et al.   CELL

Structural Basis for the Recognition of c-Src by Its Inactivator Csk

(2008) Nicholas M. Levinson et al.   CELL

CASK Functions as a Mg2+-Independent Neurexin Kinase

(2008) Konark Mukherjee et al.   CELL

Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure

(2008) David Komander et al.   EMBO JOURNAL

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

(2008) Ashley C W Pike et al.   EMBO JOURNAL

The unfolded protein response signals through high-order assembly of Ire1

(2008) Alexei V. Korennykh et al.   NATURE

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Kinomer v. 1.0: a database of systematically classified eukaryotic protein kinases

(2008) D. M. A. Martin et al.   NUCLEIC ACIDS RESEARCH

A helix scaffold for the assembly of active protein kinases

(2008) A. P. Kornev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

(2008) J. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Human Protein Kinase MPSK1 Reveals an Atypical Activation Loop Architecture

(2008) Jeyanthy Eswaran et al.   STRUCTURE

Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase

(2008) Chen Qiu et al.   STRUCTURE

Conserved spatial patterns across the protein kinase family

(2007) Lynn F. Ten Eyck et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS