Mechanistic principles of RAF kinase signaling

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

(2010) Sonja J. Heidorn et al.   CELL

Molecular and clinical analysis ofRAF1in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation

(2010) Tomoko Kobayashi et al.   HUMAN MUTATION

The Scaffold Protein Shoc2/SUR-8 Accelerates the Interaction of Ras and Raf

(2010) Rie Matsunaga-Udagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Ste20-like Kinase (Mst2) Indirectly Supports Raf-1/ERK Pathway Activity via Maintenance of Protein Phosphatase-2A Catalytic Subunit Levels and Consequent Suppression of Inhibitory Raf-1 Phosphorylation

(2010) Geoffrey K. Kilili et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ras and Calcium Signaling Pathways Converge at Raf1 via the Shoc2 Scaffold Protein

(2010) Sayaka Yoshiki et al.   MOLECULAR BIOLOGY OF THE CELL

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

(2010) Poulikos I. Poulikakos et al.   NATURE

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

(2010) Georgia Hatzivassiliou et al.   NATURE

Molecular mechanisms in signal transduction at the membrane

(2010) Jay T Groves et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A RasGTP-Induced Conformational Change in C-RAF Is Essential for Accurate Molecular Recognition

(2009) Kayo Hibino et al.   BIOPHYSICAL JOURNAL

Raf-1 Addiction in Ras-Induced Skin Carcinogenesis

(2009) Karin Ehrenreiter et al.   CANCER CELL

Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

(2009) Jayajit Das et al.   CELL

KSR2 Is an Essential Regulator of AMP Kinase, Energy Expenditure, and Insulin Sensitivity

(2009) Diane L. Costanzo-Garvey et al.   Cell Metabolism

The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch

(2009) Amardeep S. Dhillon et al.   CELLULAR SIGNALLING

Drosophila Raf's N Terminus Contains a Novel Conserved Region and Can Contribute to Torso RTK Signaling

(2009) J. Ding et al.   GENETICS

Diacylglycerol Kinase η Augments C-Raf Activity and B-Raf/C-Raf Heterodimerization

(2009) Satoshi Yasuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-α kinase activity

(2009) Théodora Niault et al.   JOURNAL OF CELL BIOLOGY

Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway

(2009) S.-Y. Shin et al.   JOURNAL OF CELL SCIENCE

Impact of Feedback Phosphorylation and Raf Heterodimerization on Normal and Mutant B-Raf Signaling

(2009) D. A. Ritt et al.   MOLECULAR AND CELLULAR BIOLOGY

C-Raf Inhibits MAPK Activation and Transformation by B-RafV600E

(2009) Florian A. Karreth et al.   MOLECULAR CELL

KSR2 Is a Calcineurin Substrate that Promotes ERK Cascade Activation in Response to Calcium Signals

(2009) Michele K. Dougherty et al.   MOLECULAR CELL

A dimerization-dependent mechanism drives RAF catalytic activation

(2009) Thanashan Rajakulendran et al.   NATURE

Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair

(2009) Viviana Cordeddu et al.   NATURE GENETICS

Signaling dynamics of the KSR1 scaffold complex

(2009) M. M. McKay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K-Ras Nanoclustering Is Subverted by Overexpression of the Scaffold Protein Galectin-3

(2008) R. Shalom-Feuerstein et al.   CANCER RESEARCH

The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK

(2008) Oliver Rath et al.   CELLULAR SIGNALLING

Characterization of Ser338Phosphorylation for Raf-1 Activation

(2008) Mengwei Zang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p21 activated kinase 5 activates Raf-1 and targets it to mitochondria

(2008) Xiaochong Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ras Subcellular Localization Defines Extracellular Signal-Regulated Kinase 1 and 2 Substrate Specificity through Distinct Utilization of Scaffold Proteins

(2008) B. Casar et al.   MOLECULAR AND CELLULAR BIOLOGY

Electrostatic Interactions Positively Regulate K-Ras Nanocluster Formation and Function

(2008) S. J. Plowman et al.   MOLECULAR AND CELLULAR BIOLOGY

Galectin-1 Is a Novel Structural Component and a Major Regulator of H-Ras Nanoclusters

(2008) Liron Belanis et al.   MOLECULAR BIOLOGY OF THE CELL

Activation of the MAPK Module from Different Spatial Locations Generates Distinct System Outputs

(2008) Kerry Inder et al.   MOLECULAR BIOLOGY OF THE CELL

Essential Role of ERK Dimers in the Activation of Cytoplasmic but Not Nuclear Substrates by ERK-Scaffold Complexes

(2008) Berta Casar et al.   MOLECULAR CELL

CRAF Autophosphorylation of Serine 621 Is Required to Prevent Its Proteasome-Mediated Degradation

(2008) Catherine Noble et al.   MOLECULAR CELL

High-throughput Screening of Mouse Knockout Lines Identifies True Lean and Obese Phenotypes

(2008) Robert Brommage et al.   Obesity

CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling

(2008) T. Rajakulendran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA